Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity

Abstract Bioprospecting identifies new sources of compounds with actual or potential economic value that come from biodiversity. An analysis was performed regarding bioprospecting purposes in ten genotypes of Sechium spp., through a meta-analysis of 20 information sources considering different varia...

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Autores principales:	María Isabel Iñiguez-Luna, Jorge Cadena-Iñiguez, Ramón Marcos Soto-Hernández, Francisco Javier Morales-Flores, Moisés Cortes-Cruz, Kazuo N. Watanabe, Ryoko Machida-Hirano, Jorge David Cadena-Zamudio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea47dcfc08d04505ba7322703ac04791
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spelling	oai:doaj.org-article:ea47dcfc08d04505ba7322703ac047912021-12-02T17:05:11ZBioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity10.1038/s41598-021-85676-72045-2322https://doaj.org/article/ea47dcfc08d04505ba7322703ac047912021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85676-7https://doaj.org/toc/2045-2322Abstract Bioprospecting identifies new sources of compounds with actual or potential economic value that come from biodiversity. An analysis was performed regarding bioprospecting purposes in ten genotypes of Sechium spp., through a meta-analysis of 20 information sources considering different variables: five morphological, 19 biochemical, anti-proliferative activity of extracts on five malignant cell lines, and 188 polymorphic bands of amplified fragment length polymorphisms, were used in order to identify the most relevant variables for the design of genetic interbreeding. Significant relationships between morphological and biochemical characters and anti-proliferative activity in cell lines were obtained, with five principal components for principal component analysis (SAS/ETS); variables were identified with a statistical significance (< 0.7 and Pearson values ≥ 0.7), with 80.81% of the accumulation of genetic variation and 110 genetic bands. Thirty-nine (39) variables were recovered using NTSYSpc software where 30 showed a Pearson correlation (> 0.5) and nine variables (< 0.05), Finally, using a cladistics analysis approach highlighted 65 genetic bands, in addition to color of the fruit, presence of thorns, bitter flavor, piriform and oblong shape, and also content of chlorophylls a and b, presence of cucurbitacins, and the IC50 effect of chayote extracts on the four cell lines.María Isabel Iñiguez-LunaJorge Cadena-IñiguezRamón Marcos Soto-HernándezFrancisco Javier Morales-FloresMoisés Cortes-CruzKazuo N. WatanabeRyoko Machida-HiranoJorge David Cadena-ZamudioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q María Isabel Iñiguez-Luna Jorge Cadena-Iñiguez Ramón Marcos Soto-Hernández Francisco Javier Morales-Flores Moisés Cortes-Cruz Kazuo N. Watanabe Ryoko Machida-Hirano Jorge David Cadena-Zamudio Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity
description	Abstract Bioprospecting identifies new sources of compounds with actual or potential economic value that come from biodiversity. An analysis was performed regarding bioprospecting purposes in ten genotypes of Sechium spp., through a meta-analysis of 20 information sources considering different variables: five morphological, 19 biochemical, anti-proliferative activity of extracts on five malignant cell lines, and 188 polymorphic bands of amplified fragment length polymorphisms, were used in order to identify the most relevant variables for the design of genetic interbreeding. Significant relationships between morphological and biochemical characters and anti-proliferative activity in cell lines were obtained, with five principal components for principal component analysis (SAS/ETS); variables were identified with a statistical significance (< 0.7 and Pearson values ≥ 0.7), with 80.81% of the accumulation of genetic variation and 110 genetic bands. Thirty-nine (39) variables were recovered using NTSYSpc software where 30 showed a Pearson correlation (> 0.5) and nine variables (< 0.05), Finally, using a cladistics analysis approach highlighted 65 genetic bands, in addition to color of the fruit, presence of thorns, bitter flavor, piriform and oblong shape, and also content of chlorophylls a and b, presence of cucurbitacins, and the IC50 effect of chayote extracts on the four cell lines.
format	article
author	María Isabel Iñiguez-Luna Jorge Cadena-Iñiguez Ramón Marcos Soto-Hernández Francisco Javier Morales-Flores Moisés Cortes-Cruz Kazuo N. Watanabe Ryoko Machida-Hirano Jorge David Cadena-Zamudio
author_facet	María Isabel Iñiguez-Luna Jorge Cadena-Iñiguez Ramón Marcos Soto-Hernández Francisco Javier Morales-Flores Moisés Cortes-Cruz Kazuo N. Watanabe Ryoko Machida-Hirano Jorge David Cadena-Zamudio
author_sort	María Isabel Iñiguez-Luna
title	Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity
title_short	Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity
title_full	Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity
title_fullStr	Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity
title_full_unstemmed	Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity
title_sort	bioprospecting of sechium spp. varieties for the selection of characters with pharmacological activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea47dcfc08d04505ba7322703ac04791
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Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity

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