Fetal-derived macrophages dominate in adult mammary glands

Tissue-resident macrophages are highly specialized phagocytes that serve multiple functions. Here, using high-dimension analyses and fate-mapping experiments, the authors show that fetal liver-derived macrophages dominate the mammary gland in neonatal and adult, and display characteristic phenotypes...

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Autores principales: Norma Jäppinen, Inês Félix, Emmi Lokka, Sofia Tyystjärvi, Anne Pynttäri, Tiina Lahtela, Heidi Gerke, Kati Elima, Pia Rantakari, Marko Salmi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ea49325d17d44c02bbbc3353aaf6dc64
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Sumario:Tissue-resident macrophages are highly specialized phagocytes that serve multiple functions. Here, using high-dimension analyses and fate-mapping experiments, the authors show that fetal liver-derived macrophages dominate the mammary gland in neonatal and adult, and display characteristic phenotypes and functions.