Fetal-derived macrophages dominate in adult mammary glands

Tissue-resident macrophages are highly specialized phagocytes that serve multiple functions. Here, using high-dimension analyses and fate-mapping experiments, the authors show that fetal liver-derived macrophages dominate the mammary gland in neonatal and adult, and display characteristic phenotypes...

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Autores principales:	Norma Jäppinen, Inês Félix, Emmi Lokka, Sofia Tyystjärvi, Anne Pynttäri, Tiina Lahtela, Heidi Gerke, Kati Elima, Pia Rantakari, Marko Salmi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea49325d17d44c02bbbc3353aaf6dc64
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spelling	oai:doaj.org-article:ea49325d17d44c02bbbc3353aaf6dc642021-12-02T17:01:34ZFetal-derived macrophages dominate in adult mammary glands10.1038/s41467-018-08065-12041-1723https://doaj.org/article/ea49325d17d44c02bbbc3353aaf6dc642019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08065-1https://doaj.org/toc/2041-1723Tissue-resident macrophages are highly specialized phagocytes that serve multiple functions. Here, using high-dimension analyses and fate-mapping experiments, the authors show that fetal liver-derived macrophages dominate the mammary gland in neonatal and adult, and display characteristic phenotypes and functions.Norma JäppinenInês FélixEmmi LokkaSofia TyystjärviAnne PynttäriTiina LahtelaHeidi GerkeKati ElimaPia RantakariMarko SalmiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Norma Jäppinen Inês Félix Emmi Lokka Sofia Tyystjärvi Anne Pynttäri Tiina Lahtela Heidi Gerke Kati Elima Pia Rantakari Marko Salmi Fetal-derived macrophages dominate in adult mammary glands
description	Tissue-resident macrophages are highly specialized phagocytes that serve multiple functions. Here, using high-dimension analyses and fate-mapping experiments, the authors show that fetal liver-derived macrophages dominate the mammary gland in neonatal and adult, and display characteristic phenotypes and functions.
format	article
author	Norma Jäppinen Inês Félix Emmi Lokka Sofia Tyystjärvi Anne Pynttäri Tiina Lahtela Heidi Gerke Kati Elima Pia Rantakari Marko Salmi
author_facet	Norma Jäppinen Inês Félix Emmi Lokka Sofia Tyystjärvi Anne Pynttäri Tiina Lahtela Heidi Gerke Kati Elima Pia Rantakari Marko Salmi
author_sort	Norma Jäppinen
title	Fetal-derived macrophages dominate in adult mammary glands
title_short	Fetal-derived macrophages dominate in adult mammary glands
title_full	Fetal-derived macrophages dominate in adult mammary glands
title_fullStr	Fetal-derived macrophages dominate in adult mammary glands
title_full_unstemmed	Fetal-derived macrophages dominate in adult mammary glands
title_sort	fetal-derived macrophages dominate in adult mammary glands
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ea49325d17d44c02bbbc3353aaf6dc64
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Fetal-derived macrophages dominate in adult mammary glands

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