Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries.

<h4>Background</h4>Prompt post-exposure prophylaxis (PEP) is essential in preventing the fatal onset of disease in persons exposed to rabies. Unfortunately, life-saving rabies vaccines and biologicals are often neither accessible nor affordable, particularly to the poorest sectors of soc...

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Autores principales:	Katie Hampson, Sarah Cleaveland, Deborah Briggs
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/ea499468232946dd901bf976eb8e1f47
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spelling	oai:doaj.org-article:ea499468232946dd901bf976eb8e1f472021-11-18T09:13:31ZEvaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries.1935-27271935-273510.1371/journal.pntd.0000982https://doaj.org/article/ea499468232946dd901bf976eb8e1f472011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21408121/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Prompt post-exposure prophylaxis (PEP) is essential in preventing the fatal onset of disease in persons exposed to rabies. Unfortunately, life-saving rabies vaccines and biologicals are often neither accessible nor affordable, particularly to the poorest sectors of society who are most at risk and upon whom the largest burden of rabies falls. Increasing accessibility, reducing costs and preventing delays in delivery of PEP should therefore be prioritized.<h4>Methodology/principal findings</h4>We analyzed different PEP vaccination regimens and evaluated their relative costs and benefits to bite victims and healthcare providers. We found PEP vaccination to be an extremely cost-effective intervention (from $200 to less than $60/death averted). Switching from intramuscular (IM) administration of PEP to equally efficacious intradermal (ID) regimens was shown to result in significant savings in the volume of vaccine required to treat the same number of patients, which could mitigate vaccine shortages, and would dramatically reduce the costs of implementing PEP. We present financing mechanisms that would make PEP more affordable and accessible, could help subsidize the cost for those most in need, and could even support new and existing rabies control and prevention programs.<h4>Conclusions/significance</h4>We conclude that a universal switch to ID delivery would improve the affordability and accessibility of PEP for bite victims, leading to a likely reduction in human rabies deaths, as well as being economical for healthcare providers.Katie HampsonSarah CleavelandDeborah BriggsPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 5, Iss 3, p e982 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Katie Hampson Sarah Cleaveland Deborah Briggs Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries.
description	<h4>Background</h4>Prompt post-exposure prophylaxis (PEP) is essential in preventing the fatal onset of disease in persons exposed to rabies. Unfortunately, life-saving rabies vaccines and biologicals are often neither accessible nor affordable, particularly to the poorest sectors of society who are most at risk and upon whom the largest burden of rabies falls. Increasing accessibility, reducing costs and preventing delays in delivery of PEP should therefore be prioritized.<h4>Methodology/principal findings</h4>We analyzed different PEP vaccination regimens and evaluated their relative costs and benefits to bite victims and healthcare providers. We found PEP vaccination to be an extremely cost-effective intervention (from $200 to less than $60/death averted). Switching from intramuscular (IM) administration of PEP to equally efficacious intradermal (ID) regimens was shown to result in significant savings in the volume of vaccine required to treat the same number of patients, which could mitigate vaccine shortages, and would dramatically reduce the costs of implementing PEP. We present financing mechanisms that would make PEP more affordable and accessible, could help subsidize the cost for those most in need, and could even support new and existing rabies control and prevention programs.<h4>Conclusions/significance</h4>We conclude that a universal switch to ID delivery would improve the affordability and accessibility of PEP for bite victims, leading to a likely reduction in human rabies deaths, as well as being economical for healthcare providers.
format	article
author	Katie Hampson Sarah Cleaveland Deborah Briggs
author_facet	Katie Hampson Sarah Cleaveland Deborah Briggs
author_sort	Katie Hampson
title	Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries.
title_short	Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries.
title_full	Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries.
title_fullStr	Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries.
title_full_unstemmed	Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries.
title_sort	evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ea499468232946dd901bf976eb8e1f47
work_keys_str_mv	AT katiehampson evaluationofcosteffectivestrategiesforrabiespostexposurevaccinationinlowincomecountries AT sarahcleaveland evaluationofcosteffectivestrategiesforrabiespostexposurevaccinationinlowincomecountries AT deborahbriggs evaluationofcosteffectivestrategiesforrabiespostexposurevaccinationinlowincomecountries
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Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries.

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