Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach

Abstract Multifunctional nanoparticles are discussed as versatile probes for homogeneous immunoassays for in-vitro diagnostics. Top-down fabrication allows to combine and tailor magnetic and plasmonic anisotropic properties. The combination of nanoimprint lithography, thin film deposition, and lift-...

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Autores principales:	Hubert Brueckl, Astrit Shoshi, Stefan Schrittwieser, Barbara Schmid, Pia Schneeweiss, Tina Mitteramskogler, Michael J. Haslinger, Michael Muehlberger, Joerg Schotter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea49e60cb272406e8c4dae398f7c0309
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spelling	oai:doaj.org-article:ea49e60cb272406e8c4dae398f7c03092021-12-02T11:39:44ZNanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach10.1038/s41598-021-85524-82045-2322https://doaj.org/article/ea49e60cb272406e8c4dae398f7c03092021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85524-8https://doaj.org/toc/2045-2322Abstract Multifunctional nanoparticles are discussed as versatile probes for homogeneous immunoassays for in-vitro diagnostics. Top-down fabrication allows to combine and tailor magnetic and plasmonic anisotropic properties. The combination of nanoimprint lithography, thin film deposition, and lift-off processing provides a top-down fabrication platform, which is both flexible and reliable. Here, we discuss the material compositions and geometrical designs of monodisperse multicomponent nanoparticles and their consequences on optical and magnetic properties. The rotational hydrodynamics of nanoparticles is measured and considered under the influence of magnetic shape anisotropy in the framework of the Stoner-Wohlfarth theory. The plasmon-optical properties are explained by discrete-dipole finite-element simulations. Rotational dynamical measurements of imprinted nanoprobes for two test proteins demonstrate the applicability as highly sensitive biomolecular nanoprobes.Hubert BruecklAstrit ShoshiStefan SchrittwieserBarbara SchmidPia SchneeweissTina MitteramskoglerMichael J. HaslingerMichael MuehlbergerJoerg SchotterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hubert Brueckl Astrit Shoshi Stefan Schrittwieser Barbara Schmid Pia Schneeweiss Tina Mitteramskogler Michael J. Haslinger Michael Muehlberger Joerg Schotter Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach
description	Abstract Multifunctional nanoparticles are discussed as versatile probes for homogeneous immunoassays for in-vitro diagnostics. Top-down fabrication allows to combine and tailor magnetic and plasmonic anisotropic properties. The combination of nanoimprint lithography, thin film deposition, and lift-off processing provides a top-down fabrication platform, which is both flexible and reliable. Here, we discuss the material compositions and geometrical designs of monodisperse multicomponent nanoparticles and their consequences on optical and magnetic properties. The rotational hydrodynamics of nanoparticles is measured and considered under the influence of magnetic shape anisotropy in the framework of the Stoner-Wohlfarth theory. The plasmon-optical properties are explained by discrete-dipole finite-element simulations. Rotational dynamical measurements of imprinted nanoprobes for two test proteins demonstrate the applicability as highly sensitive biomolecular nanoprobes.
format	article
author	Hubert Brueckl Astrit Shoshi Stefan Schrittwieser Barbara Schmid Pia Schneeweiss Tina Mitteramskogler Michael J. Haslinger Michael Muehlberger Joerg Schotter
author_facet	Hubert Brueckl Astrit Shoshi Stefan Schrittwieser Barbara Schmid Pia Schneeweiss Tina Mitteramskogler Michael J. Haslinger Michael Muehlberger Joerg Schotter
author_sort	Hubert Brueckl
title	Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach
title_short	Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach
title_full	Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach
title_fullStr	Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach
title_full_unstemmed	Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach
title_sort	nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea49e60cb272406e8c4dae398f7c0309
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Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach

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