Current Therapeutic Strategies in Patients with Oropharyngeal Squamous Cell Carcinoma: Impact of the Tumor HPV Status

Since there is no published randomized study comparing surgical and non-surgical therapeutic strategies in patients with oropharyngeal squamous cell carcinoma (OPSCC), the therapeutic management of these patients remains highly controversial. While human papillomavirus (HPV)-positive and HPV-negativ...

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Autores principales:	Alexandre Bozec, Dorian Culié, Gilles Poissonnet, François Demard, Olivier Dassonville
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oropharynx neoplasm squamous cell carcinoma human papillomavirus therapeutic management treatment selection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ea4d25db4851483aa3c2572872873bf8
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spelling	oai:doaj.org-article:ea4d25db4851483aa3c2572872873bf82021-11-11T15:33:30ZCurrent Therapeutic Strategies in Patients with Oropharyngeal Squamous Cell Carcinoma: Impact of the Tumor HPV Status10.3390/cancers132154562072-6694https://doaj.org/article/ea4d25db4851483aa3c2572872873bf82021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5456https://doaj.org/toc/2072-6694Since there is no published randomized study comparing surgical and non-surgical therapeutic strategies in patients with oropharyngeal squamous cell carcinoma (OPSCC), the therapeutic management of these patients remains highly controversial. While human papillomavirus (HPV)-positive and HPV-negative OPSCC are now recognized as two distinct diseases with different epidemiological, biological, and clinical characteristics, the impact of HPV status on the management of OPSCC patients is still unclear. In this review, we analyze the current therapeutic options in patients with OPSCC, highlighting the most recent advances in surgical and non-surgical therapies, and we discuss the impact of HPV status on the therapeutic strategy.Alexandre BozecDorian CuliéGilles PoissonnetFrançois DemardOlivier DassonvilleMDPI AGarticleoropharynxneoplasmsquamous cell carcinomahuman papillomavirustherapeutic managementtreatment selectionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5456, p 5456 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oropharynx neoplasm squamous cell carcinoma human papillomavirus therapeutic management treatment selection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	oropharynx neoplasm squamous cell carcinoma human papillomavirus therapeutic management treatment selection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Alexandre Bozec Dorian Culié Gilles Poissonnet François Demard Olivier Dassonville Current Therapeutic Strategies in Patients with Oropharyngeal Squamous Cell Carcinoma: Impact of the Tumor HPV Status
description	Since there is no published randomized study comparing surgical and non-surgical therapeutic strategies in patients with oropharyngeal squamous cell carcinoma (OPSCC), the therapeutic management of these patients remains highly controversial. While human papillomavirus (HPV)-positive and HPV-negative OPSCC are now recognized as two distinct diseases with different epidemiological, biological, and clinical characteristics, the impact of HPV status on the management of OPSCC patients is still unclear. In this review, we analyze the current therapeutic options in patients with OPSCC, highlighting the most recent advances in surgical and non-surgical therapies, and we discuss the impact of HPV status on the therapeutic strategy.
format	article
author	Alexandre Bozec Dorian Culié Gilles Poissonnet François Demard Olivier Dassonville
author_facet	Alexandre Bozec Dorian Culié Gilles Poissonnet François Demard Olivier Dassonville
author_sort	Alexandre Bozec
title	Current Therapeutic Strategies in Patients with Oropharyngeal Squamous Cell Carcinoma: Impact of the Tumor HPV Status
title_short	Current Therapeutic Strategies in Patients with Oropharyngeal Squamous Cell Carcinoma: Impact of the Tumor HPV Status
title_full	Current Therapeutic Strategies in Patients with Oropharyngeal Squamous Cell Carcinoma: Impact of the Tumor HPV Status
title_fullStr	Current Therapeutic Strategies in Patients with Oropharyngeal Squamous Cell Carcinoma: Impact of the Tumor HPV Status
title_full_unstemmed	Current Therapeutic Strategies in Patients with Oropharyngeal Squamous Cell Carcinoma: Impact of the Tumor HPV Status
title_sort	current therapeutic strategies in patients with oropharyngeal squamous cell carcinoma: impact of the tumor hpv status
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ea4d25db4851483aa3c2572872873bf8
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Current Therapeutic Strategies in Patients with Oropharyngeal Squamous Cell Carcinoma: Impact of the Tumor HPV Status

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