Serological Features of Children Vertically Infected With Hepatitis B Virus: A Study in Amir Al-Momenin Ali Hospital of Zabol

Introduction: Hepatitis B is a common viral infection worldwide and the main cause of chronic hepatitis, cirrhosis and liver cell carcinoma. hepatitis B e-antigen (HBeAg) is one of the markers indicating chronic hepatitis B infection. In this cross-sectional study, we investigate serological markers...

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Autores principales:	Iraj Shahramian, Abdolvahab Moradi, Pouya Ostadrahimi, Hadi Mirzaei, Mahboobeh Sheikh, Ali Khosravi Bonjar, Samira Abdollahi, Ali Bazi
Formato:	article
Lenguaje:	EN
Publicado:	Zabol University of Medical sciences 2021
Materias:	hepatitis b virus vertical infection aminotransferases Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ea5553babfc7422e9dc9702aa84fd5ab
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spelling	oai:doaj.org-article:ea5553babfc7422e9dc9702aa84fd5ab2021-11-17T09:55:03ZSerological Features of Children Vertically Infected With Hepatitis B Virus: A Study in Amir Al-Momenin Ali Hospital of Zabol2476-664X10.34172/ijbsm.2021.04https://doaj.org/article/ea5553babfc7422e9dc9702aa84fd5ab2021-03-01T00:00:00Zhttp://ijbsm.zbmu.ac.ir/PDF/ijbsm-22489https://doaj.org/toc/2476-664XIntroduction: Hepatitis B is a common viral infection worldwide and the main cause of chronic hepatitis, cirrhosis and liver cell carcinoma. hepatitis B e-antigen (HBeAg) is one of the markers indicating chronic hepatitis B infection. In this cross-sectional study, we investigate serological markers and HBeAg positivity in in children with maternally transmitted hepatitis B virus (HBV).Materials and Methods: Overall, 26 children with congenital HBV referred to Amir Al-Mo’menin Ali hospital in Zabol in 2019 and 2020 were enrolled. After gathering demographic characteristics, blood samples were taken from the patients. Serological tests were performed by routine ELISA tests. Data were analyzed using SPSS software version 22.Results: Twenty-six children were included in the study;18 of them (69.2%) were males. The mean age of the participants was 13.98±11 years (minimum of 1 and maximum of 18 years old). The mean age of mothers was 40.45±10 years (minimum of 27 and maximum of 63 years old). Four (15.4%) of the children were HBeAg positive, and 18 (69.2%) were HBeAb positive with no significant differences between genders (P > 0.05). HBeAg positivity was not associated with the birth rank (P = 0.71) or HBV vaccination (P = 0.17). Liver enzymes, serum albumin and children’s age and duration of maternal infection were not significantly different between HBeAg positive and HBeAg negative groups (P > 0.05). Mean serum alanine transaminase (ALT) was significantly higher in HBeAb positive than HBeAb negative children (P = 0.018), and HBeAb positivity was significantly associated with HBV vaccination history (P = 0.02). Other liver enzymes as well as age of mother and child and the duration of maternal infection were not significantly different between the two groups (P > 0.99). Conclusion: The prevalence of chronic HBV infection based on HBeAg positivity was relatively high in children vertically infected with the virus. HBeAb seroconversion seems to be associated with HBV vaccination.Iraj ShahramianAbdolvahab MoradiPouya OstadrahimiHadi MirzaeiMahboobeh SheikhAli Khosravi BonjarSamira AbdollahiAli BaziZabol University of Medical sciencesarticlehepatitis b virus vertical infection aminotransferases Medicine (General)R5-920ENInternational Journal of Basic Science in Medicine, Vol 6, Iss 1, Pp 25-29 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatitis b virus vertical infection aminotransferases Medicine (General) R5-920
spellingShingle	hepatitis b virus vertical infection aminotransferases Medicine (General) R5-920 Iraj Shahramian Abdolvahab Moradi Pouya Ostadrahimi Hadi Mirzaei Mahboobeh Sheikh Ali Khosravi Bonjar Samira Abdollahi Ali Bazi Serological Features of Children Vertically Infected With Hepatitis B Virus: A Study in Amir Al-Momenin Ali Hospital of Zabol
description	Introduction: Hepatitis B is a common viral infection worldwide and the main cause of chronic hepatitis, cirrhosis and liver cell carcinoma. hepatitis B e-antigen (HBeAg) is one of the markers indicating chronic hepatitis B infection. In this cross-sectional study, we investigate serological markers and HBeAg positivity in in children with maternally transmitted hepatitis B virus (HBV).Materials and Methods: Overall, 26 children with congenital HBV referred to Amir Al-Mo’menin Ali hospital in Zabol in 2019 and 2020 were enrolled. After gathering demographic characteristics, blood samples were taken from the patients. Serological tests were performed by routine ELISA tests. Data were analyzed using SPSS software version 22.Results: Twenty-six children were included in the study;18 of them (69.2%) were males. The mean age of the participants was 13.98±11 years (minimum of 1 and maximum of 18 years old). The mean age of mothers was 40.45±10 years (minimum of 27 and maximum of 63 years old). Four (15.4%) of the children were HBeAg positive, and 18 (69.2%) were HBeAb positive with no significant differences between genders (P > 0.05). HBeAg positivity was not associated with the birth rank (P = 0.71) or HBV vaccination (P = 0.17). Liver enzymes, serum albumin and children’s age and duration of maternal infection were not significantly different between HBeAg positive and HBeAg negative groups (P > 0.05). Mean serum alanine transaminase (ALT) was significantly higher in HBeAb positive than HBeAb negative children (P = 0.018), and HBeAb positivity was significantly associated with HBV vaccination history (P = 0.02). Other liver enzymes as well as age of mother and child and the duration of maternal infection were not significantly different between the two groups (P > 0.99). Conclusion: The prevalence of chronic HBV infection based on HBeAg positivity was relatively high in children vertically infected with the virus. HBeAb seroconversion seems to be associated with HBV vaccination.
format	article
author	Iraj Shahramian Abdolvahab Moradi Pouya Ostadrahimi Hadi Mirzaei Mahboobeh Sheikh Ali Khosravi Bonjar Samira Abdollahi Ali Bazi
author_facet	Iraj Shahramian Abdolvahab Moradi Pouya Ostadrahimi Hadi Mirzaei Mahboobeh Sheikh Ali Khosravi Bonjar Samira Abdollahi Ali Bazi
author_sort	Iraj Shahramian
title	Serological Features of Children Vertically Infected With Hepatitis B Virus: A Study in Amir Al-Momenin Ali Hospital of Zabol
title_short	Serological Features of Children Vertically Infected With Hepatitis B Virus: A Study in Amir Al-Momenin Ali Hospital of Zabol
title_full	Serological Features of Children Vertically Infected With Hepatitis B Virus: A Study in Amir Al-Momenin Ali Hospital of Zabol
title_fullStr	Serological Features of Children Vertically Infected With Hepatitis B Virus: A Study in Amir Al-Momenin Ali Hospital of Zabol
title_full_unstemmed	Serological Features of Children Vertically Infected With Hepatitis B Virus: A Study in Amir Al-Momenin Ali Hospital of Zabol
title_sort	serological features of children vertically infected with hepatitis b virus: a study in amir al-momenin ali hospital of zabol
publisher	Zabol University of Medical sciences
publishDate	2021
url	https://doaj.org/article/ea5553babfc7422e9dc9702aa84fd5ab
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Serological Features of Children Vertically Infected With Hepatitis B Virus: A Study in Amir Al-Momenin Ali Hospital of Zabol

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