Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2

Koichiro Ono et al. report that Dmrt2 is a critical transcription factor for chondrocyte maturation during endochondral ossification. The study shows that Dmrt2 is the direct target of Sox9 and acts as a transcriptional coactivator of Runx2 providing novel insights into the transcription factor netw...

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Autores principales:	Koichiro Ono, Kenji Hata, Eriko Nakamura, Shota Ishihara, Sachi Kobayashi, Masako Nakanishi, Michiko Yoshida, Yoshifumi Takahata, Tomohiko Murakami, Seiichi Takenoshita, Toshihisa Komori, Riko Nishimura, Toshiyuki Yoneda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ea57b097864a4a5aa98c9580d3f4f6a3
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spelling	oai:doaj.org-article:ea57b097864a4a5aa98c9580d3f4f6a32021-12-02T13:33:50ZDmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx210.1038/s42003-021-01848-12399-3642https://doaj.org/article/ea57b097864a4a5aa98c9580d3f4f6a32021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01848-1https://doaj.org/toc/2399-3642Koichiro Ono et al. report that Dmrt2 is a critical transcription factor for chondrocyte maturation during endochondral ossification. The study shows that Dmrt2 is the direct target of Sox9 and acts as a transcriptional coactivator of Runx2 providing novel insights into the transcription factor network during skeletal development.Koichiro OnoKenji HataEriko NakamuraShota IshiharaSachi KobayashiMasako NakanishiMichiko YoshidaYoshifumi TakahataTomohiko MurakamiSeiichi TakenoshitaToshihisa KomoriRiko NishimuraToshiyuki YonedaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Koichiro Ono Kenji Hata Eriko Nakamura Shota Ishihara Sachi Kobayashi Masako Nakanishi Michiko Yoshida Yoshifumi Takahata Tomohiko Murakami Seiichi Takenoshita Toshihisa Komori Riko Nishimura Toshiyuki Yoneda Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2
description	Koichiro Ono et al. report that Dmrt2 is a critical transcription factor for chondrocyte maturation during endochondral ossification. The study shows that Dmrt2 is the direct target of Sox9 and acts as a transcriptional coactivator of Runx2 providing novel insights into the transcription factor network during skeletal development.
format	article
author	Koichiro Ono Kenji Hata Eriko Nakamura Shota Ishihara Sachi Kobayashi Masako Nakanishi Michiko Yoshida Yoshifumi Takahata Tomohiko Murakami Seiichi Takenoshita Toshihisa Komori Riko Nishimura Toshiyuki Yoneda
author_facet	Koichiro Ono Kenji Hata Eriko Nakamura Shota Ishihara Sachi Kobayashi Masako Nakanishi Michiko Yoshida Yoshifumi Takahata Tomohiko Murakami Seiichi Takenoshita Toshihisa Komori Riko Nishimura Toshiyuki Yoneda
author_sort	Koichiro Ono
title	Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2
title_short	Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2
title_full	Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2
title_fullStr	Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2
title_full_unstemmed	Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2
title_sort	dmrt2 promotes transition of endochondral bone formation by linking sox9 and runx2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea57b097864a4a5aa98c9580d3f4f6a3
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Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2

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