Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes

Meiotic recombination density is increased on shorter chromosomes. Here the authors show that recombination initiation continues near all chromosome ends long after interstitial regions become quiescent in a process that proportionally benefits short chromosomes.

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Detalles Bibliográficos
Autores principales: Vijayalakshmi V. Subramanian, Xuan Zhu, Tovah E. Markowitz, Luis A. Vale-Silva, Pedro A. San-Segundo, Nancy M. Hollingsworth, Scott Keeney, Andreas Hochwagen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ea5a09e10b4b468fb01ea1d0f4fada81
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Sumario:Meiotic recombination density is increased on shorter chromosomes. Here the authors show that recombination initiation continues near all chromosome ends long after interstitial regions become quiescent in a process that proportionally benefits short chromosomes.