Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice

X-linked myotubular myopathy is caused by mutations in the gene coding for myotubularin 1, and is characterized by overexpression of dynamin 2. Here the authors develop antisense oligonucleotides to dynamin 2, and show that systemic injection leads to improved pathology in mice.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hichem Tasfaout, Suzie Buono, Shuling Guo, Christine Kretz, Nadia Messaddeq, Sheri Booten, Sarah Greenlee, Brett P. Monia, Belinda S. Cowling, Jocelyn Laporte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea5ef61a87bf47839d28720d6a64f759
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ea5ef61a87bf47839d28720d6a64f759
record_format	dspace
spelling	oai:doaj.org-article:ea5ef61a87bf47839d28720d6a64f7592021-12-02T14:41:59ZAntisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice10.1038/ncomms156612041-1723https://doaj.org/article/ea5ef61a87bf47839d28720d6a64f7592017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15661https://doaj.org/toc/2041-1723X-linked myotubular myopathy is caused by mutations in the gene coding for myotubularin 1, and is characterized by overexpression of dynamin 2. Here the authors develop antisense oligonucleotides to dynamin 2, and show that systemic injection leads to improved pathology in mice.Hichem TasfaoutSuzie BuonoShuling GuoChristine KretzNadia MessaddeqSheri BootenSarah GreenleeBrett P. MoniaBelinda S. CowlingJocelyn LaporteNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hichem Tasfaout Suzie Buono Shuling Guo Christine Kretz Nadia Messaddeq Sheri Booten Sarah Greenlee Brett P. Monia Belinda S. Cowling Jocelyn Laporte Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice
description	X-linked myotubular myopathy is caused by mutations in the gene coding for myotubularin 1, and is characterized by overexpression of dynamin 2. Here the authors develop antisense oligonucleotides to dynamin 2, and show that systemic injection leads to improved pathology in mice.
format	article
author	Hichem Tasfaout Suzie Buono Shuling Guo Christine Kretz Nadia Messaddeq Sheri Booten Sarah Greenlee Brett P. Monia Belinda S. Cowling Jocelyn Laporte
author_facet	Hichem Tasfaout Suzie Buono Shuling Guo Christine Kretz Nadia Messaddeq Sheri Booten Sarah Greenlee Brett P. Monia Belinda S. Cowling Jocelyn Laporte
author_sort	Hichem Tasfaout
title	Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice
title_short	Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice
title_full	Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice
title_fullStr	Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice
title_full_unstemmed	Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice
title_sort	antisense oligonucleotide-mediated dnm2 knockdown prevents and reverts myotubular myopathy in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ea5ef61a87bf47839d28720d6a64f759
work_keys_str_mv	AT hichemtasfaout antisenseoligonucleotidemediateddnm2knockdownpreventsandrevertsmyotubularmyopathyinmice AT suziebuono antisenseoligonucleotidemediateddnm2knockdownpreventsandrevertsmyotubularmyopathyinmice AT shulingguo antisenseoligonucleotidemediateddnm2knockdownpreventsandrevertsmyotubularmyopathyinmice AT christinekretz antisenseoligonucleotidemediateddnm2knockdownpreventsandrevertsmyotubularmyopathyinmice AT nadiamessaddeq antisenseoligonucleotidemediateddnm2knockdownpreventsandrevertsmyotubularmyopathyinmice AT sheribooten antisenseoligonucleotidemediateddnm2knockdownpreventsandrevertsmyotubularmyopathyinmice AT sarahgreenlee antisenseoligonucleotidemediateddnm2knockdownpreventsandrevertsmyotubularmyopathyinmice AT brettpmonia antisenseoligonucleotidemediateddnm2knockdownpreventsandrevertsmyotubularmyopathyinmice AT belindascowling antisenseoligonucleotidemediateddnm2knockdownpreventsandrevertsmyotubularmyopathyinmice AT jocelynlaporte antisenseoligonucleotidemediateddnm2knockdownpreventsandrevertsmyotubularmyopathyinmice
_version_	1718389843961053184

Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice

Ejemplares similares