The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses

Abstract Ever since the uncultivated South American fungal pathogen Lacazia loboi was first described 90 years ago, its etiology and evolutionary traits have been at the center of endless controversies. This pathogen infects the skin of humans and as long believed, dolphin skin. However, recent DNA...

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Autores principales:	Raquel Vilela, Marianne Huebner, Camila Vilela, Gabriella Vilela, Bruno Pettersen, Claudia Oliveira, Leonel Mendoza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea6073b49da8426faddd06e762657c3f
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spelling	oai:doaj.org-article:ea6073b49da8426faddd06e762657c3f2021-12-02T15:15:35ZThe taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses10.1038/s41598-021-97429-72045-2322https://doaj.org/article/ea6073b49da8426faddd06e762657c3f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97429-7https://doaj.org/toc/2045-2322Abstract Ever since the uncultivated South American fungal pathogen Lacazia loboi was first described 90 years ago, its etiology and evolutionary traits have been at the center of endless controversies. This pathogen infects the skin of humans and as long believed, dolphin skin. However, recent DNA analyses of infected dolphins placed its DNA sequences within Paracoccidioides species. This came as a surprise and suggested the human and dolphin pathogens may be different species. In this study, population genetic analyses of DNA from four infected dolphins grouped this pathogen in a monophyletic cluster sister to P. americana and to the other Paracoccidioides species. Based on the results we have emended the taxonomy of the dolphin pathogen as Paracoccidioides cetii and P. loboi the one infecting human. Our data warn that phylogenetic analysis of available taxa without the inclusion of unusual members may provide incomplete information for the accurate classification of anomalous species.Raquel VilelaMarianne HuebnerCamila VilelaGabriella VilelaBruno PettersenClaudia OliveiraLeonel MendozaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Raquel Vilela Marianne Huebner Camila Vilela Gabriella Vilela Bruno Pettersen Claudia Oliveira Leonel Mendoza The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses
description	Abstract Ever since the uncultivated South American fungal pathogen Lacazia loboi was first described 90 years ago, its etiology and evolutionary traits have been at the center of endless controversies. This pathogen infects the skin of humans and as long believed, dolphin skin. However, recent DNA analyses of infected dolphins placed its DNA sequences within Paracoccidioides species. This came as a surprise and suggested the human and dolphin pathogens may be different species. In this study, population genetic analyses of DNA from four infected dolphins grouped this pathogen in a monophyletic cluster sister to P. americana and to the other Paracoccidioides species. Based on the results we have emended the taxonomy of the dolphin pathogen as Paracoccidioides cetii and P. loboi the one infecting human. Our data warn that phylogenetic analysis of available taxa without the inclusion of unusual members may provide incomplete information for the accurate classification of anomalous species.
format	article
author	Raquel Vilela Marianne Huebner Camila Vilela Gabriella Vilela Bruno Pettersen Claudia Oliveira Leonel Mendoza
author_facet	Raquel Vilela Marianne Huebner Camila Vilela Gabriella Vilela Bruno Pettersen Claudia Oliveira Leonel Mendoza
author_sort	Raquel Vilela
title	The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses
title_short	The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses
title_full	The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses
title_fullStr	The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses
title_full_unstemmed	The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses
title_sort	taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea6073b49da8426faddd06e762657c3f
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The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses

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