Bone tissue response to porous and functionalized titanium and silica based coatings.

<h4>Background</h4>Topography and presence of bio-mimetic coatings are known to improve osseointegration. The objective of this study was to evaluate the bone regeneration potential of porous and osteogenic coatings.<h4>Methodology</h4>Six-implants [Control (CTR); porous tita...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amol Chaudhari, Annabel Braem, Jozef Vleugels, Johan A Martens, Ignace Naert, Marcio Vivan Cardoso, Joke Duyck
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea633b4cd31d4d2c90e30c130ea84d7d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ea633b4cd31d4d2c90e30c130ea84d7d
record_format	dspace
spelling	oai:doaj.org-article:ea633b4cd31d4d2c90e30c130ea84d7d2021-11-04T06:08:34ZBone tissue response to porous and functionalized titanium and silica based coatings.1932-620310.1371/journal.pone.0024186https://doaj.org/article/ea633b4cd31d4d2c90e30c130ea84d7d2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21935382/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Topography and presence of bio-mimetic coatings are known to improve osseointegration. The objective of this study was to evaluate the bone regeneration potential of porous and osteogenic coatings.<h4>Methodology</h4>Six-implants [Control (CTR); porous titanium coatings (T1, T2); thickened titanium (Ti) dioxide layer (TiO(2)); Amorphous Microporous Silica (AMS) and Bio-active Glass (BAG)] were implanted randomly in tibiae of 20-New Zealand white rabbits. The animals were sacrificed after 2 or 4 weeks. The samples were analyzed histologically and histomorphometrically. In the initial bone-free areas (bone regeneration areas (BRAs)), the bone area fraction (BAF) was evaluated in the whole cavity (500 µm, BAF-500), in the implant vicinity (100 µm, BAF-100) and further away (100-500 µm, BAF-400) from the implant. Bone-to-implant contact (BIC-BAA) was measured in the areas where the implants were installed in contact to the host bone (bone adaptation areas (BAAs)) to understand and compare the bone adaptation. Mixed models were used for statistical analysis.<h4>Principal findings</h4>After 2 weeks, the differences in BAF-500 for different surfaces were not significant (p>0.05). After 4 weeks, a higher BAF-500 was observed for BAG than CTR. BAF-100 for AMS was higher than BAG and BAF-400 for BAG was higher than CTR and AMS. For T1 and AMS, the bone regeneration was faster in the 100-µm compared to the 400-µm zone. BIC-BAA for AMS and BAG was lower after 4 than 2 weeks. After 4 weeks, BIC-BAA for BAG was lower than AMS and CTR.<h4>Conclusions</h4>BAG is highly osteogenic at a distance from the implant. The porous titanium coatings didn't stimulate bone regeneration but allowed bone growth into the pores. Although AMS didn't stimulate higher bone response, it has a potential of faster bone growth in the vicinity compared to further away from the surface. BIC-BAA data were inconclusive to understand the bone adaptation.Amol ChaudhariAnnabel BraemJozef VleugelsJohan A MartensIgnace NaertMarcio Vivan CardosoJoke DuyckPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24186 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amol Chaudhari Annabel Braem Jozef Vleugels Johan A Martens Ignace Naert Marcio Vivan Cardoso Joke Duyck Bone tissue response to porous and functionalized titanium and silica based coatings.
description	<h4>Background</h4>Topography and presence of bio-mimetic coatings are known to improve osseointegration. The objective of this study was to evaluate the bone regeneration potential of porous and osteogenic coatings.<h4>Methodology</h4>Six-implants [Control (CTR); porous titanium coatings (T1, T2); thickened titanium (Ti) dioxide layer (TiO(2)); Amorphous Microporous Silica (AMS) and Bio-active Glass (BAG)] were implanted randomly in tibiae of 20-New Zealand white rabbits. The animals were sacrificed after 2 or 4 weeks. The samples were analyzed histologically and histomorphometrically. In the initial bone-free areas (bone regeneration areas (BRAs)), the bone area fraction (BAF) was evaluated in the whole cavity (500 µm, BAF-500), in the implant vicinity (100 µm, BAF-100) and further away (100-500 µm, BAF-400) from the implant. Bone-to-implant contact (BIC-BAA) was measured in the areas where the implants were installed in contact to the host bone (bone adaptation areas (BAAs)) to understand and compare the bone adaptation. Mixed models were used for statistical analysis.<h4>Principal findings</h4>After 2 weeks, the differences in BAF-500 for different surfaces were not significant (p>0.05). After 4 weeks, a higher BAF-500 was observed for BAG than CTR. BAF-100 for AMS was higher than BAG and BAF-400 for BAG was higher than CTR and AMS. For T1 and AMS, the bone regeneration was faster in the 100-µm compared to the 400-µm zone. BIC-BAA for AMS and BAG was lower after 4 than 2 weeks. After 4 weeks, BIC-BAA for BAG was lower than AMS and CTR.<h4>Conclusions</h4>BAG is highly osteogenic at a distance from the implant. The porous titanium coatings didn't stimulate bone regeneration but allowed bone growth into the pores. Although AMS didn't stimulate higher bone response, it has a potential of faster bone growth in the vicinity compared to further away from the surface. BIC-BAA data were inconclusive to understand the bone adaptation.
format	article
author	Amol Chaudhari Annabel Braem Jozef Vleugels Johan A Martens Ignace Naert Marcio Vivan Cardoso Joke Duyck
author_facet	Amol Chaudhari Annabel Braem Jozef Vleugels Johan A Martens Ignace Naert Marcio Vivan Cardoso Joke Duyck
author_sort	Amol Chaudhari
title	Bone tissue response to porous and functionalized titanium and silica based coatings.
title_short	Bone tissue response to porous and functionalized titanium and silica based coatings.
title_full	Bone tissue response to porous and functionalized titanium and silica based coatings.
title_fullStr	Bone tissue response to porous and functionalized titanium and silica based coatings.
title_full_unstemmed	Bone tissue response to porous and functionalized titanium and silica based coatings.
title_sort	bone tissue response to porous and functionalized titanium and silica based coatings.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ea633b4cd31d4d2c90e30c130ea84d7d
work_keys_str_mv	AT amolchaudhari bonetissueresponsetoporousandfunctionalizedtitaniumandsilicabasedcoatings AT annabelbraem bonetissueresponsetoporousandfunctionalizedtitaniumandsilicabasedcoatings AT jozefvleugels bonetissueresponsetoporousandfunctionalizedtitaniumandsilicabasedcoatings AT johanamartens bonetissueresponsetoporousandfunctionalizedtitaniumandsilicabasedcoatings AT ignacenaert bonetissueresponsetoporousandfunctionalizedtitaniumandsilicabasedcoatings AT marciovivancardoso bonetissueresponsetoporousandfunctionalizedtitaniumandsilicabasedcoatings AT jokeduyck bonetissueresponsetoporousandfunctionalizedtitaniumandsilicabasedcoatings
_version_	1718445184771948544

Bone tissue response to porous and functionalized titanium and silica based coatings.

Ejemplares similares