Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM

ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine producti...

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Autores principales:	Hongming Miao, Juanjuan Ou, Yuan Peng, Xuan Zhang, Yujuan Chen, Lijun Hao, Ganfeng Xie, Zhe Wang, Xueli Pang, Zhihua Ruan, Jianjun Li, Liqing Yu, Bingzhong Xue, Hang Shi, Chunmeng Shi, Houjie Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea637eebb1c5495fbd40d2648ecc7300
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:ea637eebb1c5495fbd40d2648ecc73002021-12-02T15:34:59ZMacrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM10.1038/ncomms117162041-1723https://doaj.org/article/ea637eebb1c5495fbd40d2648ecc73002016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11716https://doaj.org/toc/2041-1723ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production.Hongming MiaoJuanjuan OuYuan PengXuan ZhangYujuan ChenLijun HaoGanfeng XieZhe WangXueli PangZhihua RuanJianjun LiLiqing YuBingzhong XueHang ShiChunmeng ShiHoujie LiangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongming Miao Juanjuan Ou Yuan Peng Xuan Zhang Yujuan Chen Lijun Hao Ganfeng Xie Zhe Wang Xueli Pang Zhihua Ruan Jianjun Li Liqing Yu Bingzhong Xue Hang Shi Chunmeng Shi Houjie Liang Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
description	ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production.
format	article
author	Hongming Miao Juanjuan Ou Yuan Peng Xuan Zhang Yujuan Chen Lijun Hao Ganfeng Xie Zhe Wang Xueli Pang Zhihua Ruan Jianjun Li Liqing Yu Bingzhong Xue Hang Shi Chunmeng Shi Houjie Liang
author_facet	Hongming Miao Juanjuan Ou Yuan Peng Xuan Zhang Yujuan Chen Lijun Hao Ganfeng Xie Zhe Wang Xueli Pang Zhihua Ruan Jianjun Li Liqing Yu Bingzhong Xue Hang Shi Chunmeng Shi Houjie Liang
author_sort	Hongming Miao
title	Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
title_short	Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
title_full	Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
title_fullStr	Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
title_full_unstemmed	Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
title_sort	macrophage abhd5 promotes colorectal cancer growth by suppressing spermidine production by srm
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ea637eebb1c5495fbd40d2648ecc7300
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Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM

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