Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM

Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM

ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine producti...

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Autores principales: Hongming Miao, Juanjuan Ou, Yuan Peng, Xuan Zhang, Yujuan Chen, Lijun Hao, Ganfeng Xie, Zhe Wang, Xueli Pang, Zhihua Ruan, Jianjun Li, Liqing Yu, Bingzhong Xue, Hang Shi, Chunmeng Shi, Houjie Liang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/ea637eebb1c5495fbd40d2648ecc7300
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