Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis

Abstract Background and purpose Hashimoto thyroiditis (HT) is the most common inflammatory autoimmune thyroid disease and also the most common cause of hypothyroidism in developed countries. There is evidence of the role of HT in developing thyroid cancers (TCs). This study investigated the associat...

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Autores principales:	Pouya Abbasgholizadeh, Amirreza Naseri, Ehsan Nasiri, Vahideh Sadra
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Hashimoto Thyroiditis Chronic autoimmune thyroiditis Thyroid neoplasms Systematic review Meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/ea6564185b6e46b39f901fc77277f539
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spelling	oai:doaj.org-article:ea6564185b6e46b39f901fc77277f5392021-12-05T12:05:21ZIs Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis10.1186/s13044-021-00117-x1756-6614https://doaj.org/article/ea6564185b6e46b39f901fc77277f5392021-12-01T00:00:00Zhttps://doi.org/10.1186/s13044-021-00117-xhttps://doaj.org/toc/1756-6614Abstract Background and purpose Hashimoto thyroiditis (HT) is the most common inflammatory autoimmune thyroid disease and also the most common cause of hypothyroidism in developed countries. There is evidence of the role of HT in developing thyroid cancers (TCs). This study investigated the association between HT and different types of TCs. Methods Results of a comprehensive search in three major databases, as well as hand searching, were screened in title/abstract and full-text stages and the relevant data were extracted from the studies that met the inclusion criteria. Risk of bias (RoB) was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools and the meta-analysis was conducted with Comprehensive Meta-Analysis software. Results Out of 4785 records, 50 studies were included in the systematic review, and 27 of them met the criteria for quantitative synthesis. The results indicated a significant role for HT in developing papillary TC (OR: 1.65; 95% CI: 1.04 to 2.61), medullary TC (OR: 2.70; 95% CI: 1.20 to 6.07) and lymphoma (OR:12.92; 95% CI: 2.15 to 77.63); but not anaplastic TC (OR: 1.92; 95% CI: 0.29 to 1.90) and follicular TC (OR: 0.73; 95% CI: 0.41 to 1.27). Also, this study found a significant association between HT and thyroid malignancies (OR: 1.36; 95% CI: 1.05 to 1.77). Conclusion Although we found a significant association between HT and some types of TCs, High RoB studies, high level of heterogeneity, and the limited number of well-designed prospective studies, suggested the need for more studies to reach more reliable evidence.Pouya AbbasgholizadehAmirreza NaseriEhsan NasiriVahideh SadraBMCarticleHashimoto ThyroiditisChronic autoimmune thyroiditisThyroid neoplasmsSystematic reviewMeta-analysisDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENThyroid Research, Vol 14, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hashimoto Thyroiditis Chronic autoimmune thyroiditis Thyroid neoplasms Systematic review Meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Hashimoto Thyroiditis Chronic autoimmune thyroiditis Thyroid neoplasms Systematic review Meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665 Pouya Abbasgholizadeh Amirreza Naseri Ehsan Nasiri Vahideh Sadra Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis
description	Abstract Background and purpose Hashimoto thyroiditis (HT) is the most common inflammatory autoimmune thyroid disease and also the most common cause of hypothyroidism in developed countries. There is evidence of the role of HT in developing thyroid cancers (TCs). This study investigated the association between HT and different types of TCs. Methods Results of a comprehensive search in three major databases, as well as hand searching, were screened in title/abstract and full-text stages and the relevant data were extracted from the studies that met the inclusion criteria. Risk of bias (RoB) was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools and the meta-analysis was conducted with Comprehensive Meta-Analysis software. Results Out of 4785 records, 50 studies were included in the systematic review, and 27 of them met the criteria for quantitative synthesis. The results indicated a significant role for HT in developing papillary TC (OR: 1.65; 95% CI: 1.04 to 2.61), medullary TC (OR: 2.70; 95% CI: 1.20 to 6.07) and lymphoma (OR:12.92; 95% CI: 2.15 to 77.63); but not anaplastic TC (OR: 1.92; 95% CI: 0.29 to 1.90) and follicular TC (OR: 0.73; 95% CI: 0.41 to 1.27). Also, this study found a significant association between HT and thyroid malignancies (OR: 1.36; 95% CI: 1.05 to 1.77). Conclusion Although we found a significant association between HT and some types of TCs, High RoB studies, high level of heterogeneity, and the limited number of well-designed prospective studies, suggested the need for more studies to reach more reliable evidence.
format	article
author	Pouya Abbasgholizadeh Amirreza Naseri Ehsan Nasiri Vahideh Sadra
author_facet	Pouya Abbasgholizadeh Amirreza Naseri Ehsan Nasiri Vahideh Sadra
author_sort	Pouya Abbasgholizadeh
title	Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis
title_short	Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis
title_full	Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis
title_fullStr	Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis
title_full_unstemmed	Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis
title_sort	is hashimoto thyroiditis associated with increasing risk of thyroid malignancies? a systematic review and meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ea6564185b6e46b39f901fc77277f539
work_keys_str_mv	AT pouyaabbasgholizadeh ishashimotothyroiditisassociatedwithincreasingriskofthyroidmalignanciesasystematicreviewandmetaanalysis AT amirrezanaseri ishashimotothyroiditisassociatedwithincreasingriskofthyroidmalignanciesasystematicreviewandmetaanalysis AT ehsannasiri ishashimotothyroiditisassociatedwithincreasingriskofthyroidmalignanciesasystematicreviewandmetaanalysis AT vahidehsadra ishashimotothyroiditisassociatedwithincreasingriskofthyroidmalignanciesasystematicreviewandmetaanalysis
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Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis

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