Animal Models of Complex Regional Pain Syndrome Type I

Yu Liu,1 Ying Liang,1 Min Gao,1 Yingchun Li,1 Tingting Zhao,2 Yani Zhao1 1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi, 030032, People’s Republic of China; 2Shaanxi University of Traditional Chinese...

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Autores principales:	Liu Y, Liang Y, Gao M, Li Y, Zhao T, Zhao Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	crps reflex sympathetic dystrophy animal model mouse rat sex diet psychology Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ea6cc9624e5b44f69eb4e23e63b698f6
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spelling	oai:doaj.org-article:ea6cc9624e5b44f69eb4e23e63b698f62021-12-05T18:27:45ZAnimal Models of Complex Regional Pain Syndrome Type I1178-7090https://doaj.org/article/ea6cc9624e5b44f69eb4e23e63b698f62021-12-01T00:00:00Zhttps://www.dovepress.com/animal-models-of-complex-regional-pain-syndrome-type-i-peer-reviewed-fulltext-article-JPRhttps://doaj.org/toc/1178-7090Yu Liu,1 Ying Liang,1 Min Gao,1 Yingchun Li,1 Tingting Zhao,2 Yani Zhao1 1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi, 030032, People’s Republic of China; 2Shaanxi University of Traditional Chinese Medicine, Xi’an, Shaanxi, 712046, People’s Republic of ChinaCorrespondence: Ying LiangThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, No. 99, Longcheng Street, Xiaodian District, Taiyuan, Shanxi, 030032, People’s Republic of ChinaTel +86-13934225687Email sx.liangying@126.comAbstract: Complex regional pain syndrome (CRPS) is a chronic pain disorder characterized by spontaneous or evoked regionally-confined pain which is out of proportion to the initial trauma event. The disease can seriously affect the quality of the patients’ life, increase the psychological burden, and cause various degrees of disability. Despite the awareness of CRPS among medical practitioners for over a century, its pathogenesis remains unclear, and the available treatment is still unsatisfactory. Effective animal models are the foundation of disease research, which is helpful in understanding the pathogenesis and an in-depth exploration of the appropriate therapeutic approaches. Currently, researchers have established a series of animal models of the disease. There are four main CRPSI animal models: chronic post-ischemic pain (CPIP) model, tibial fracture/cast immobilization model, passive transfer-trauma model, and the needlestick-nerve-injury (NNI) model. The modeling methods of these models are constantly improving over time. In preclinical studies, the interpretation of experimental results and the horizontal comparison between similar studies may be affected by the nature of the experimental animal breeds, sex, diet, and psychology. There is need to facilitate the choice of appropriate animal models and avoid the interference of the factors influencing animal models on the interpretation of research results. The review will provide a basic overview of the influencing factors, modeling methods, and the characteristics of CRPSI animal models.Keywords: CRPS, reflex sympathetic dystrophy, animal model, mouse, rat, sex, diet, psychologyLiu YLiang YGao MLi YZhao TZhao YDove Medical Pressarticlecrpsreflex sympathetic dystrophyanimal modelmouseratsexdietpsychologyMedicine (General)R5-920ENJournal of Pain Research, Vol Volume 14, Pp 3711-3721 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	crps reflex sympathetic dystrophy animal model mouse rat sex diet psychology Medicine (General) R5-920
spellingShingle	crps reflex sympathetic dystrophy animal model mouse rat sex diet psychology Medicine (General) R5-920 Liu Y Liang Y Gao M Li Y Zhao T Zhao Y Animal Models of Complex Regional Pain Syndrome Type I
description	Yu Liu,1 Ying Liang,1 Min Gao,1 Yingchun Li,1 Tingting Zhao,2 Yani Zhao1 1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi, 030032, People’s Republic of China; 2Shaanxi University of Traditional Chinese Medicine, Xi’an, Shaanxi, 712046, People’s Republic of ChinaCorrespondence: Ying LiangThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, No. 99, Longcheng Street, Xiaodian District, Taiyuan, Shanxi, 030032, People’s Republic of ChinaTel +86-13934225687Email sx.liangying@126.comAbstract: Complex regional pain syndrome (CRPS) is a chronic pain disorder characterized by spontaneous or evoked regionally-confined pain which is out of proportion to the initial trauma event. The disease can seriously affect the quality of the patients’ life, increase the psychological burden, and cause various degrees of disability. Despite the awareness of CRPS among medical practitioners for over a century, its pathogenesis remains unclear, and the available treatment is still unsatisfactory. Effective animal models are the foundation of disease research, which is helpful in understanding the pathogenesis and an in-depth exploration of the appropriate therapeutic approaches. Currently, researchers have established a series of animal models of the disease. There are four main CRPSI animal models: chronic post-ischemic pain (CPIP) model, tibial fracture/cast immobilization model, passive transfer-trauma model, and the needlestick-nerve-injury (NNI) model. The modeling methods of these models are constantly improving over time. In preclinical studies, the interpretation of experimental results and the horizontal comparison between similar studies may be affected by the nature of the experimental animal breeds, sex, diet, and psychology. There is need to facilitate the choice of appropriate animal models and avoid the interference of the factors influencing animal models on the interpretation of research results. The review will provide a basic overview of the influencing factors, modeling methods, and the characteristics of CRPSI animal models.Keywords: CRPS, reflex sympathetic dystrophy, animal model, mouse, rat, sex, diet, psychology
format	article
author	Liu Y Liang Y Gao M Li Y Zhao T Zhao Y
author_facet	Liu Y Liang Y Gao M Li Y Zhao T Zhao Y
author_sort	Liu Y
title	Animal Models of Complex Regional Pain Syndrome Type I
title_short	Animal Models of Complex Regional Pain Syndrome Type I
title_full	Animal Models of Complex Regional Pain Syndrome Type I
title_fullStr	Animal Models of Complex Regional Pain Syndrome Type I
title_full_unstemmed	Animal Models of Complex Regional Pain Syndrome Type I
title_sort	animal models of complex regional pain syndrome type i
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ea6cc9624e5b44f69eb4e23e63b698f6
work_keys_str_mv	AT liuy animalmodelsofcomplexregionalpainsyndrometypei AT liangy animalmodelsofcomplexregionalpainsyndrometypei AT gaom animalmodelsofcomplexregionalpainsyndrometypei AT liy animalmodelsofcomplexregionalpainsyndrometypei AT zhaot animalmodelsofcomplexregionalpainsyndrometypei AT zhaoy animalmodelsofcomplexregionalpainsyndrometypei
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Animal Models of Complex Regional Pain Syndrome Type I

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