Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

This review focuses on key topics in the field of drug delivery related to the design of nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and the ability to overcome biological barriers. For these reasons, much attention is paid to the amph...

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Autores principales:	Gulnara Gaynanova, Leysan Vasileva, Ruslan Kashapov, Darya Kuznetsova, Rushana Kushnazarova, Anna Tyryshkina, Elmira Vasilieva, Konstantin Petrov, Lucia Zakharova, Oleg Sinyashin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biological barrier surfactant nanocontainer nanoparticle micelle niosome Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/ea713ebd76bf4212947fc39a26e273ee
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spelling	oai:doaj.org-article:ea713ebd76bf4212947fc39a26e273ee2021-11-25T18:27:14ZSelf-Assembling Drug Formulations with Tunable Permeability and Biodegradability10.3390/molecules262267861420-3049https://doaj.org/article/ea713ebd76bf4212947fc39a26e273ee2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6786https://doaj.org/toc/1420-3049This review focuses on key topics in the field of drug delivery related to the design of nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and the ability to overcome biological barriers. For these reasons, much attention is paid to the amphiphile-based carriers composed of natural building blocks, lipids, and their structural analogues and synthetic surfactants that are capable of self-assembly with the formation of a variety of supramolecular aggregates. The latter are dynamic structures that can be used as nanocontainers for hydrophobic drugs to increase their solubility and bioavailability. In this section, biodegradable cationic surfactants bearing cleavable fragments are discussed, with ester- and carbamate-containing analogs, as well as amino acid derivatives received special attention. Drug delivery through the biological barriers is a challenging task, which is highlighted by the example of transdermal method of drug administration. In this paper, nonionic surfactants are primarily discussed, including their application for the fabrication of nanocarriers, their surfactant-skin interactions, the mechanisms of modulating their permeability, and the factors controlling drug encapsulation, release, and targeted delivery. Different types of nanocarriers are covered, including niosomes, transfersomes, invasomes and chitosomes, with their morphological specificity, beneficial characteristics and limitations discussed.Gulnara GaynanovaLeysan VasilevaRuslan KashapovDarya KuznetsovaRushana KushnazarovaAnna TyryshkinaElmira VasilievaKonstantin PetrovLucia ZakharovaOleg SinyashinMDPI AGarticlebiological barriersurfactantnanocontainernanoparticlemicelleniosomeOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6786, p 6786 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biological barrier surfactant nanocontainer nanoparticle micelle niosome Organic chemistry QD241-441
spellingShingle	biological barrier surfactant nanocontainer nanoparticle micelle niosome Organic chemistry QD241-441 Gulnara Gaynanova Leysan Vasileva Ruslan Kashapov Darya Kuznetsova Rushana Kushnazarova Anna Tyryshkina Elmira Vasilieva Konstantin Petrov Lucia Zakharova Oleg Sinyashin Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability
description	This review focuses on key topics in the field of drug delivery related to the design of nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and the ability to overcome biological barriers. For these reasons, much attention is paid to the amphiphile-based carriers composed of natural building blocks, lipids, and their structural analogues and synthetic surfactants that are capable of self-assembly with the formation of a variety of supramolecular aggregates. The latter are dynamic structures that can be used as nanocontainers for hydrophobic drugs to increase their solubility and bioavailability. In this section, biodegradable cationic surfactants bearing cleavable fragments are discussed, with ester- and carbamate-containing analogs, as well as amino acid derivatives received special attention. Drug delivery through the biological barriers is a challenging task, which is highlighted by the example of transdermal method of drug administration. In this paper, nonionic surfactants are primarily discussed, including their application for the fabrication of nanocarriers, their surfactant-skin interactions, the mechanisms of modulating their permeability, and the factors controlling drug encapsulation, release, and targeted delivery. Different types of nanocarriers are covered, including niosomes, transfersomes, invasomes and chitosomes, with their morphological specificity, beneficial characteristics and limitations discussed.
format	article
author	Gulnara Gaynanova Leysan Vasileva Ruslan Kashapov Darya Kuznetsova Rushana Kushnazarova Anna Tyryshkina Elmira Vasilieva Konstantin Petrov Lucia Zakharova Oleg Sinyashin
author_facet	Gulnara Gaynanova Leysan Vasileva Ruslan Kashapov Darya Kuznetsova Rushana Kushnazarova Anna Tyryshkina Elmira Vasilieva Konstantin Petrov Lucia Zakharova Oleg Sinyashin
author_sort	Gulnara Gaynanova
title	Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability
title_short	Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability
title_full	Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability
title_fullStr	Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability
title_full_unstemmed	Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability
title_sort	self-assembling drug formulations with tunable permeability and biodegradability
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ea713ebd76bf4212947fc39a26e273ee
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_version_	1718411167532056576

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

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