Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice.

Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice.

<h4>Background</h4>Inflammation and fibrogenesis are directly related to chronic liver disease progression, including hepatocellular carcinoma (HCC) development. Currently there are few therapeutic options available to inhibit liver fibrosis. We have evaluated the hepatoprotective and an...

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Main Authors: M Ujue Latasa, Carmen Gil-Puig, Maite G Fernández-Barrena, Carlos M Rodríguez-Ortigosa, Jesús M Banales, Raquel Urtasun, Saioa Goñi, Miriam Méndez, Sara Arcelus, Nerea Juanarena, Juan A Recio, Sophie Lotersztajn, Jesús Prieto, Carmen Berasain, Fernando J Corrales, Jon Lecanda, Matías A Avila
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/ea72f5c5f43e4344b69e60e69b24e059
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