Antioxidative and Hypoglycemic Effect of Ta-ermi Extracts on Streptozotocin-Induced Diabetes

Siqun Jing,1 Zhengmei Zhao,2 Jinzi Wu,3 Liang-Jun Yan3 1Yingdong Food College, Shaoguan Unversity, Shaoguan, Guangdong 512005, People’s Republic of China; 2College of Life Sciences and Technology, Xinjiang University, Urumqi, Xinjiang 830046, People’s Republic of China; 3Departme...

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Autores principales:	Jing S, Zhao Z, Wu J, Yan LJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	ta-ermi extracts antioxidant activity anti-diabetic mitochondrial complex i streptozotocin Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ea732387490f4e41984e31c208a83e98
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spelling	oai:doaj.org-article:ea732387490f4e41984e31c208a83e982021-12-02T13:13:00ZAntioxidative and Hypoglycemic Effect of Ta-ermi Extracts on Streptozotocin-Induced Diabetes1178-7007https://doaj.org/article/ea732387490f4e41984e31c208a83e982020-06-01T00:00:00Zhttps://www.dovepress.com/antioxidative-and-hypoglycemic-effect-of-ta-ermi-extracts-on-streptozo-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Siqun Jing,1 Zhengmei Zhao,2 Jinzi Wu,3 Liang-Jun Yan3 1Yingdong Food College, Shaoguan Unversity, Shaoguan, Guangdong 512005, People’s Republic of China; 2College of Life Sciences and Technology, Xinjiang University, Urumqi, Xinjiang 830046, People’s Republic of China; 3Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USACorrespondence: Siqun Jing; Liang-Jun Yan Tel/ Fax +86-0751-8120167; Tel +1 817-735-2386; Fax +1 817-735-2603Email jingsiqun@163.com; liang-jun.yan@unthsc.eduIntroduction: The purpose of the present study was to reveal the potential positive effect of the Ta-ermi extracts on oxidative stress and streptozotocin (STZ)-diabetic mice and rats treated with Ta-ermi water- and alcohol-extracts.Methods: The study was carried out using three experimental model: 1) in vitro experiments whereby Ta-ermi extracts were incubated with free radical generators such as 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and 2,2ʹ-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) to evaluate Ta-ermi’s antioxidant effects; 2) testing the hypoglycemic effects of Ta-ermi extracts in streptozotocin (STZ)-induced diabetic mice; and 3) testing the beneficial effects of Ta-ermi extracts on mitochondrial complex I function using STZ-diabetic rats.Results: In vitro antioxidant experiments showed that both of the extracts could scavenge free radicals and exhibited inhibitory effects on glucosidase and aldose reductase with differential effects between water extract and alcohol extract. In the STZ mouse diabetic model, both the water- and alcohol-extracts attenuated body weight decrease, decreased blood glucose levels in a concentration-dependent manner, improved insulin sensitivity, and increased oral glucose tolerance ability. In the STZ-diabetic rat model, both the water- and alcohol-extracts were found to be able to lower blood glucose levels in the diabetic animals with no effects on body weight changes. Moreover, in the STZ-diabetic rats, both the water- and alcohol-extracts of Ta-ermi could inhibit the increase of mitochondrial NADH/ubiquinone oxidoreductase (complex I) activity in the pancreas and enhanced complex I activity in the liver but showed no effect on lung or kidney mitochondrial complex I.Discussion: The present study points to the potential medicinal value of Ta-ermi’s water and alcohol extracts in lowering blood glucose and decreasing diabetic oxidative stress. One limitation of our study is that the compound or compounds that actually have this beneficial effect in the extracts remain unknown at this time. Therefore, the future studies should be focused on the identification of the components in the extracts that exhibit anti-oxidative and hypoglycemic effects.Conclusion: Taken together, our studies using different experimental paradigms indicate that Ta-ermi extracts possess antioxidant and anti-diabetic properties and may be employed as functional food ingredients for the remission of diabetes.Keywords: Ta-ermi extracts, antioxidant activity, anti-diabetic, mitochondrial complex I, streptozotocinJing SZhao ZWu JYan LJDove Medical Pressarticleta-ermi extractsantioxidant activityanti-diabeticmitochondrial complex istreptozotocinSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2147-2155 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ta-ermi extracts antioxidant activity anti-diabetic mitochondrial complex i streptozotocin Specialties of internal medicine RC581-951
spellingShingle	ta-ermi extracts antioxidant activity anti-diabetic mitochondrial complex i streptozotocin Specialties of internal medicine RC581-951 Jing S Zhao Z Wu J Yan LJ Antioxidative and Hypoglycemic Effect of Ta-ermi Extracts on Streptozotocin-Induced Diabetes
description	Siqun Jing,1 Zhengmei Zhao,2 Jinzi Wu,3 Liang-Jun Yan3 1Yingdong Food College, Shaoguan Unversity, Shaoguan, Guangdong 512005, People’s Republic of China; 2College of Life Sciences and Technology, Xinjiang University, Urumqi, Xinjiang 830046, People’s Republic of China; 3Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USACorrespondence: Siqun Jing; Liang-Jun Yan Tel/ Fax +86-0751-8120167; Tel +1 817-735-2386; Fax +1 817-735-2603Email jingsiqun@163.com; liang-jun.yan@unthsc.eduIntroduction: The purpose of the present study was to reveal the potential positive effect of the Ta-ermi extracts on oxidative stress and streptozotocin (STZ)-diabetic mice and rats treated with Ta-ermi water- and alcohol-extracts.Methods: The study was carried out using three experimental model: 1) in vitro experiments whereby Ta-ermi extracts were incubated with free radical generators such as 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and 2,2ʹ-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) to evaluate Ta-ermi’s antioxidant effects; 2) testing the hypoglycemic effects of Ta-ermi extracts in streptozotocin (STZ)-induced diabetic mice; and 3) testing the beneficial effects of Ta-ermi extracts on mitochondrial complex I function using STZ-diabetic rats.Results: In vitro antioxidant experiments showed that both of the extracts could scavenge free radicals and exhibited inhibitory effects on glucosidase and aldose reductase with differential effects between water extract and alcohol extract. In the STZ mouse diabetic model, both the water- and alcohol-extracts attenuated body weight decrease, decreased blood glucose levels in a concentration-dependent manner, improved insulin sensitivity, and increased oral glucose tolerance ability. In the STZ-diabetic rat model, both the water- and alcohol-extracts were found to be able to lower blood glucose levels in the diabetic animals with no effects on body weight changes. Moreover, in the STZ-diabetic rats, both the water- and alcohol-extracts of Ta-ermi could inhibit the increase of mitochondrial NADH/ubiquinone oxidoreductase (complex I) activity in the pancreas and enhanced complex I activity in the liver but showed no effect on lung or kidney mitochondrial complex I.Discussion: The present study points to the potential medicinal value of Ta-ermi’s water and alcohol extracts in lowering blood glucose and decreasing diabetic oxidative stress. One limitation of our study is that the compound or compounds that actually have this beneficial effect in the extracts remain unknown at this time. Therefore, the future studies should be focused on the identification of the components in the extracts that exhibit anti-oxidative and hypoglycemic effects.Conclusion: Taken together, our studies using different experimental paradigms indicate that Ta-ermi extracts possess antioxidant and anti-diabetic properties and may be employed as functional food ingredients for the remission of diabetes.Keywords: Ta-ermi extracts, antioxidant activity, anti-diabetic, mitochondrial complex I, streptozotocin
format	article
author	Jing S Zhao Z Wu J Yan LJ
author_facet	Jing S Zhao Z Wu J Yan LJ
author_sort	Jing S
title	Antioxidative and Hypoglycemic Effect of Ta-ermi Extracts on Streptozotocin-Induced Diabetes
title_short	Antioxidative and Hypoglycemic Effect of Ta-ermi Extracts on Streptozotocin-Induced Diabetes
title_full	Antioxidative and Hypoglycemic Effect of Ta-ermi Extracts on Streptozotocin-Induced Diabetes
title_fullStr	Antioxidative and Hypoglycemic Effect of Ta-ermi Extracts on Streptozotocin-Induced Diabetes
title_full_unstemmed	Antioxidative and Hypoglycemic Effect of Ta-ermi Extracts on Streptozotocin-Induced Diabetes
title_sort	antioxidative and hypoglycemic effect of ta-ermi extracts on streptozotocin-induced diabetes
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ea732387490f4e41984e31c208a83e98
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Antioxidative and Hypoglycemic Effect of Ta-ermi Extracts on Streptozotocin-Induced Diabetes

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