ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways

Leukemic cells depend on the nucleotide synthesis pathway to proliferate. Here the authors use metabolomics and proteomics to show that inhibition of ATR reduced the activity of these pathways thus providing a valuable therapeutic target in leukemia.

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Autores principales:	Thuc M. Le, Soumya Poddar, Joseph R. Capri, Evan R. Abt, Woosuk Kim, Liu Wei, Nhu T. Uong, Chloe M. Cheng, Daniel Braas, Mina Nikanjam, Peter Rix, Daria Merkurjev, Jesse Zaretsky, Harley I. Kornblum, Antoni Ribas, Harvey R. Herschman, Julian Whitelegge, Kym F. Faull, Timothy R. Donahue, Johannes Czernin, Caius G. Radu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea735642f5484b8db7d0f34fe2f452fc
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spelling	oai:doaj.org-article:ea735642f5484b8db7d0f34fe2f452fc2021-12-02T14:16:04ZATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways10.1038/s41467-017-00221-32041-1723https://doaj.org/article/ea735642f5484b8db7d0f34fe2f452fc2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00221-3https://doaj.org/toc/2041-1723Leukemic cells depend on the nucleotide synthesis pathway to proliferate. Here the authors use metabolomics and proteomics to show that inhibition of ATR reduced the activity of these pathways thus providing a valuable therapeutic target in leukemia.Thuc M. LeSoumya PoddarJoseph R. CapriEvan R. AbtWoosuk KimLiu WeiNhu T. UongChloe M. ChengDaniel BraasMina NikanjamPeter RixDaria MerkurjevJesse ZaretskyHarley I. KornblumAntoni RibasHarvey R. HerschmanJulian WhiteleggeKym F. FaullTimothy R. DonahueJohannes CzerninCaius G. RaduNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thuc M. Le Soumya Poddar Joseph R. Capri Evan R. Abt Woosuk Kim Liu Wei Nhu T. Uong Chloe M. Cheng Daniel Braas Mina Nikanjam Peter Rix Daria Merkurjev Jesse Zaretsky Harley I. Kornblum Antoni Ribas Harvey R. Herschman Julian Whitelegge Kym F. Faull Timothy R. Donahue Johannes Czernin Caius G. Radu ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways
description	Leukemic cells depend on the nucleotide synthesis pathway to proliferate. Here the authors use metabolomics and proteomics to show that inhibition of ATR reduced the activity of these pathways thus providing a valuable therapeutic target in leukemia.
format	article
author	Thuc M. Le Soumya Poddar Joseph R. Capri Evan R. Abt Woosuk Kim Liu Wei Nhu T. Uong Chloe M. Cheng Daniel Braas Mina Nikanjam Peter Rix Daria Merkurjev Jesse Zaretsky Harley I. Kornblum Antoni Ribas Harvey R. Herschman Julian Whitelegge Kym F. Faull Timothy R. Donahue Johannes Czernin Caius G. Radu
author_facet	Thuc M. Le Soumya Poddar Joseph R. Capri Evan R. Abt Woosuk Kim Liu Wei Nhu T. Uong Chloe M. Cheng Daniel Braas Mina Nikanjam Peter Rix Daria Merkurjev Jesse Zaretsky Harley I. Kornblum Antoni Ribas Harvey R. Herschman Julian Whitelegge Kym F. Faull Timothy R. Donahue Johannes Czernin Caius G. Radu
author_sort	Thuc M. Le
title	ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways
title_short	ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways
title_full	ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways
title_fullStr	ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways
title_full_unstemmed	ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways
title_sort	atr inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ea735642f5484b8db7d0f34fe2f452fc
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ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways

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