Serum 25(OH)D is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from Northern Argentina.

<h4>Background</h4>Several studies have shown an association between vitamin D deficiency and cardiovascular risk. Vitamin D status is assessed by determination of 25-hydroxyvitamin D [25(OH)D] in serum.<h4>Methods</h4>We assessed the prognostic utility of 25(OH)D in 982 ches...

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Autores principales:	Patrycja A Naesgaard, Ricardo A León De La Fuente, Stein Tore Nilsen, Leik Woie, Torbjoern Aarsland, Cato Brede, Harry Staines, Dennis W T Nilsen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea77df6b112c44d58ab3d516e3f2eed6
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spelling	oai:doaj.org-article:ea77df6b112c44d58ab3d516e3f2eed62021-11-18T07:06:29ZSerum 25(OH)D is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from Northern Argentina.1932-620310.1371/journal.pone.0043228https://doaj.org/article/ea77df6b112c44d58ab3d516e3f2eed62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22970121/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Several studies have shown an association between vitamin D deficiency and cardiovascular risk. Vitamin D status is assessed by determination of 25-hydroxyvitamin D [25(OH)D] in serum.<h4>Methods</h4>We assessed the prognostic utility of 25(OH)D in 982 chest-pain patients with suspected acute coronary syndrome (ACS) from Salta, Northern Argentina. 2-year follow-up data including all-cause mortality, cardiac death and sudden cardiac death were analyzed in quartiles of 25(OH)D, applying univariate and multivariate analysis.<h4>Results</h4>There were statistically significant changes in seasonal 25(OH)D levels. At follow-up, 119 patients had died. The mean 25(OH)D levels were significantly lower among patients dying than in long-term survivors, both in the total population and in patients with a troponin T (TnT) release (n = 388). When comparing 25(OH)D in the highest quartile to the lowest quartile in a multivariable Cox regression model for all-cause mortality, the hazard ratio (HR) for cardiac death and sudden cardiac death in the total population was 0.37 (95% CI, 0.19-0.73), p = 0.004, 0.23 (95% CI, 0.08-0.67), p = 0.007, and 0.32 (95% CI, 0.11-0.94), p = 0.038, respectively. In patients with TnT release, the respective HR was 0.24 (95% CI, 0.10-0.54), p = 0.001, 0.18 (95% CI, 0.05-0.60), p = 0.006 and 0.25 (95% CI, 0.07-0.89), p = 0.033. 25(OH)D had no prognostic value in patients with no TnT release.<h4>Conclusion</h4>Vitamin D was shown to be a useful biomarker for prediction of mortality when obtained at admission in chest pain patients with suspected ACS.<h4>Trial registration</h4>ClinicalTrials.gov NCT01377402.Patrycja A NaesgaardRicardo A León De La FuenteStein Tore NilsenLeik WoieTorbjoern AarslandCato BredeHarry StainesDennis W T NilsenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e43228 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patrycja A Naesgaard Ricardo A León De La Fuente Stein Tore Nilsen Leik Woie Torbjoern Aarsland Cato Brede Harry Staines Dennis W T Nilsen Serum 25(OH)D is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from Northern Argentina.
description	<h4>Background</h4>Several studies have shown an association between vitamin D deficiency and cardiovascular risk. Vitamin D status is assessed by determination of 25-hydroxyvitamin D [25(OH)D] in serum.<h4>Methods</h4>We assessed the prognostic utility of 25(OH)D in 982 chest-pain patients with suspected acute coronary syndrome (ACS) from Salta, Northern Argentina. 2-year follow-up data including all-cause mortality, cardiac death and sudden cardiac death were analyzed in quartiles of 25(OH)D, applying univariate and multivariate analysis.<h4>Results</h4>There were statistically significant changes in seasonal 25(OH)D levels. At follow-up, 119 patients had died. The mean 25(OH)D levels were significantly lower among patients dying than in long-term survivors, both in the total population and in patients with a troponin T (TnT) release (n = 388). When comparing 25(OH)D in the highest quartile to the lowest quartile in a multivariable Cox regression model for all-cause mortality, the hazard ratio (HR) for cardiac death and sudden cardiac death in the total population was 0.37 (95% CI, 0.19-0.73), p = 0.004, 0.23 (95% CI, 0.08-0.67), p = 0.007, and 0.32 (95% CI, 0.11-0.94), p = 0.038, respectively. In patients with TnT release, the respective HR was 0.24 (95% CI, 0.10-0.54), p = 0.001, 0.18 (95% CI, 0.05-0.60), p = 0.006 and 0.25 (95% CI, 0.07-0.89), p = 0.033. 25(OH)D had no prognostic value in patients with no TnT release.<h4>Conclusion</h4>Vitamin D was shown to be a useful biomarker for prediction of mortality when obtained at admission in chest pain patients with suspected ACS.<h4>Trial registration</h4>ClinicalTrials.gov NCT01377402.
format	article
author	Patrycja A Naesgaard Ricardo A León De La Fuente Stein Tore Nilsen Leik Woie Torbjoern Aarsland Cato Brede Harry Staines Dennis W T Nilsen
author_facet	Patrycja A Naesgaard Ricardo A León De La Fuente Stein Tore Nilsen Leik Woie Torbjoern Aarsland Cato Brede Harry Staines Dennis W T Nilsen
author_sort	Patrycja A Naesgaard
title	Serum 25(OH)D is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from Northern Argentina.
title_short	Serum 25(OH)D is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from Northern Argentina.
title_full	Serum 25(OH)D is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from Northern Argentina.
title_fullStr	Serum 25(OH)D is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from Northern Argentina.
title_full_unstemmed	Serum 25(OH)D is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from Northern Argentina.
title_sort	serum 25(oh)d is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from northern argentina.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ea77df6b112c44d58ab3d516e3f2eed6
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Serum 25(OH)D is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from Northern Argentina.

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