Multi-functional Ultrasonic Micro-elastography Imaging System

Abstract In clinical decision making, in addition to anatomical information, biomechanical properties of soft tissues may provide additional clues for disease diagnosis. Given the fact that most of diseases are originated from micron sized structures, an elastography imaging system of fine resolutio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xuejun Qian, Teng Ma, Mingyue Yu, Xiaoyang Chen, K. Kirk Shung, Qifa Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea785dfccbc24b84bd8f45aa9f939a28
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ea785dfccbc24b84bd8f45aa9f939a28
record_format	dspace
spelling	oai:doaj.org-article:ea785dfccbc24b84bd8f45aa9f939a282021-12-02T11:52:19ZMulti-functional Ultrasonic Micro-elastography Imaging System10.1038/s41598-017-01210-82045-2322https://doaj.org/article/ea785dfccbc24b84bd8f45aa9f939a282017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01210-8https://doaj.org/toc/2045-2322Abstract In clinical decision making, in addition to anatomical information, biomechanical properties of soft tissues may provide additional clues for disease diagnosis. Given the fact that most of diseases are originated from micron sized structures, an elastography imaging system of fine resolution (~100 µm) and deep penetration depth capable of providing both qualitative and quantitative measurements of biomechanical properties is desired. Here, we report a newly developed multi-functional ultrasonic micro-elastography imaging system in which acoustic radiation force impulse imaging (ARFI) and shear wave elasticity imaging (SWEI) are implemented. To accomplish this, the 4.5 MHz/40 MHz transducer were used as the excitation/detection source, respectively. The imaging system was tested with tissue-mimicking phantoms and an ex vivo chicken liver through 2D/3D imaging. The measured lateral/axial elastography resolution and field of view are 223.7 ± 20.1/109.8 ± 6.9 µm and 1.5 mm for ARFI, 543.6 ± 39.3/117.6 ± 8.7 µm and 2 mm for SWEI, respectively. These results demonstrate that the promising capability of this high resolution elastography imaging system for characterizing tissue biomechanical properties at microscale level and its translational potential into clinical practice.Xuejun QianTeng MaMingyue YuXiaoyang ChenK. Kirk ShungQifa ZhouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xuejun Qian Teng Ma Mingyue Yu Xiaoyang Chen K. Kirk Shung Qifa Zhou Multi-functional Ultrasonic Micro-elastography Imaging System
description	Abstract In clinical decision making, in addition to anatomical information, biomechanical properties of soft tissues may provide additional clues for disease diagnosis. Given the fact that most of diseases are originated from micron sized structures, an elastography imaging system of fine resolution (~100 µm) and deep penetration depth capable of providing both qualitative and quantitative measurements of biomechanical properties is desired. Here, we report a newly developed multi-functional ultrasonic micro-elastography imaging system in which acoustic radiation force impulse imaging (ARFI) and shear wave elasticity imaging (SWEI) are implemented. To accomplish this, the 4.5 MHz/40 MHz transducer were used as the excitation/detection source, respectively. The imaging system was tested with tissue-mimicking phantoms and an ex vivo chicken liver through 2D/3D imaging. The measured lateral/axial elastography resolution and field of view are 223.7 ± 20.1/109.8 ± 6.9 µm and 1.5 mm for ARFI, 543.6 ± 39.3/117.6 ± 8.7 µm and 2 mm for SWEI, respectively. These results demonstrate that the promising capability of this high resolution elastography imaging system for characterizing tissue biomechanical properties at microscale level and its translational potential into clinical practice.
format	article
author	Xuejun Qian Teng Ma Mingyue Yu Xiaoyang Chen K. Kirk Shung Qifa Zhou
author_facet	Xuejun Qian Teng Ma Mingyue Yu Xiaoyang Chen K. Kirk Shung Qifa Zhou
author_sort	Xuejun Qian
title	Multi-functional Ultrasonic Micro-elastography Imaging System
title_short	Multi-functional Ultrasonic Micro-elastography Imaging System
title_full	Multi-functional Ultrasonic Micro-elastography Imaging System
title_fullStr	Multi-functional Ultrasonic Micro-elastography Imaging System
title_full_unstemmed	Multi-functional Ultrasonic Micro-elastography Imaging System
title_sort	multi-functional ultrasonic micro-elastography imaging system
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ea785dfccbc24b84bd8f45aa9f939a28
work_keys_str_mv	AT xuejunqian multifunctionalultrasonicmicroelastographyimagingsystem AT tengma multifunctionalultrasonicmicroelastographyimagingsystem AT mingyueyu multifunctionalultrasonicmicroelastographyimagingsystem AT xiaoyangchen multifunctionalultrasonicmicroelastographyimagingsystem AT kkirkshung multifunctionalultrasonicmicroelastographyimagingsystem AT qifazhou multifunctionalultrasonicmicroelastographyimagingsystem
_version_	1718395137995833344

Multi-functional Ultrasonic Micro-elastography Imaging System

Ejemplares similares