Reproducing the Rift Valley fever virus mosquito-lamb-mosquito transmission cycle

Abstract Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus that is pathogenic to ruminants and humans. The virus is endemic to Africa and the Arabian Peninsula where outbreaks are characterized by abortion storms and mortality of newborns, particularly in sheep herds. Vector competence e...

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Autores principales:	Paul J. Wichgers Schreur, Rianka P. M. Vloet, Jet Kant, Lucien van Keulen, Jose L. Gonzales, Tessa M. Visser, Constantianus J. M. Koenraadt, Chantal B. F. Vogels, Jeroen Kortekaas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea7a60821d884662a51742074da12e3d
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spelling	oai:doaj.org-article:ea7a60821d884662a51742074da12e3d2021-12-02T14:12:07ZReproducing the Rift Valley fever virus mosquito-lamb-mosquito transmission cycle10.1038/s41598-020-79267-12045-2322https://doaj.org/article/ea7a60821d884662a51742074da12e3d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79267-1https://doaj.org/toc/2045-2322Abstract Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus that is pathogenic to ruminants and humans. The virus is endemic to Africa and the Arabian Peninsula where outbreaks are characterized by abortion storms and mortality of newborns, particularly in sheep herds. Vector competence experiments in laboratory settings have suggested that over 50 mosquito species are capable of transmitting RVFV. Transmission of mosquito-borne viruses in the field is however influenced by numerous factors, including population densities, blood feeding behavior, extrinsic incubation period, longevity of vectors, and viremia levels in vertebrate hosts. Animal models to study these important aspects of RVFV transmission are currently lacking. In the present work, RVFV was transmitted to European (Texel-swifter cross-breed) lambs by laboratory-reared Aedes aegypti mosquitoes that were infected either by membrane feeding on a virus-spiked blood meal or by feeding on lambs that developed viremia after intravenous inoculation of RVFV. Feeding of mosquitoes on viremic lambs resulted in strikingly higher infection rates as compared to membrane feeding. Subsequent transmission of RVFV from lamb to lamb by infected mosquitoes was highly efficient in both models. The animal models described here can be used to study mosquito-mediated transmission of RVFV among the major natural target species and to evaluate the efficacy of vaccines against mosquito-mediated RVFV infection.Paul J. Wichgers SchreurRianka P. M. VloetJet KantLucien van KeulenJose L. GonzalesTessa M. VisserConstantianus J. M. KoenraadtChantal B. F. VogelsJeroen KortekaasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paul J. Wichgers Schreur Rianka P. M. Vloet Jet Kant Lucien van Keulen Jose L. Gonzales Tessa M. Visser Constantianus J. M. Koenraadt Chantal B. F. Vogels Jeroen Kortekaas Reproducing the Rift Valley fever virus mosquito-lamb-mosquito transmission cycle
description	Abstract Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus that is pathogenic to ruminants and humans. The virus is endemic to Africa and the Arabian Peninsula where outbreaks are characterized by abortion storms and mortality of newborns, particularly in sheep herds. Vector competence experiments in laboratory settings have suggested that over 50 mosquito species are capable of transmitting RVFV. Transmission of mosquito-borne viruses in the field is however influenced by numerous factors, including population densities, blood feeding behavior, extrinsic incubation period, longevity of vectors, and viremia levels in vertebrate hosts. Animal models to study these important aspects of RVFV transmission are currently lacking. In the present work, RVFV was transmitted to European (Texel-swifter cross-breed) lambs by laboratory-reared Aedes aegypti mosquitoes that were infected either by membrane feeding on a virus-spiked blood meal or by feeding on lambs that developed viremia after intravenous inoculation of RVFV. Feeding of mosquitoes on viremic lambs resulted in strikingly higher infection rates as compared to membrane feeding. Subsequent transmission of RVFV from lamb to lamb by infected mosquitoes was highly efficient in both models. The animal models described here can be used to study mosquito-mediated transmission of RVFV among the major natural target species and to evaluate the efficacy of vaccines against mosquito-mediated RVFV infection.
format	article
author	Paul J. Wichgers Schreur Rianka P. M. Vloet Jet Kant Lucien van Keulen Jose L. Gonzales Tessa M. Visser Constantianus J. M. Koenraadt Chantal B. F. Vogels Jeroen Kortekaas
author_facet	Paul J. Wichgers Schreur Rianka P. M. Vloet Jet Kant Lucien van Keulen Jose L. Gonzales Tessa M. Visser Constantianus J. M. Koenraadt Chantal B. F. Vogels Jeroen Kortekaas
author_sort	Paul J. Wichgers Schreur
title	Reproducing the Rift Valley fever virus mosquito-lamb-mosquito transmission cycle
title_short	Reproducing the Rift Valley fever virus mosquito-lamb-mosquito transmission cycle
title_full	Reproducing the Rift Valley fever virus mosquito-lamb-mosquito transmission cycle
title_fullStr	Reproducing the Rift Valley fever virus mosquito-lamb-mosquito transmission cycle
title_full_unstemmed	Reproducing the Rift Valley fever virus mosquito-lamb-mosquito transmission cycle
title_sort	reproducing the rift valley fever virus mosquito-lamb-mosquito transmission cycle
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea7a60821d884662a51742074da12e3d
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Reproducing the Rift Valley fever virus mosquito-lamb-mosquito transmission cycle

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