An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting

Abstract Bioprinting is increasingly used to create complex tissue constructs for an array of research applications, and there are also increasing efforts to print tissues for transplantation. Bioprinting may also prove valuable in the context of drug screening for personalized medicine for treatmen...

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Autores principales:	Adam Engberg, Christina Stelzl, Olle Eriksson, Paul O’Callaghan, Johan Kreuger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea7f6922969646c992d59c4e42d5dff0
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spelling	oai:doaj.org-article:ea7f6922969646c992d59c4e42d5dff02021-11-08T10:55:07ZAn open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting10.1038/s41598-021-00931-12045-2322https://doaj.org/article/ea7f6922969646c992d59c4e42d5dff02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00931-1https://doaj.org/toc/2045-2322Abstract Bioprinting is increasingly used to create complex tissue constructs for an array of research applications, and there are also increasing efforts to print tissues for transplantation. Bioprinting may also prove valuable in the context of drug screening for personalized medicine for treatment of diseases such as cancer. However, the rapidly expanding bioprinting research field is currently limited by access to bioprinters. To increase the availability of bioprinting technologies we present here an open source extrusion bioprinter based on the E3D motion system and tool changer to enable high-resolution multimaterial bioprinting. As proof of concept, the bioprinter is used to create collagen constructs using freeform reversible embedding of suspended hydrogels (FRESH) methodology, as well as multimaterial constructs composed of distinct sections of laminin and collagen. Data is presented demonstrating that the bioprinted constructs support growth of cells either seeded onto printed constructs or included in the bioink prior to bioprinting. This open source bioprinter is easily adapted for different bioprinting applications, and additional tools can be incorporated to increase the capabilities of the system.Adam EngbergChristina StelzlOlle ErikssonPaul O’CallaghanJohan KreugerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adam Engberg Christina Stelzl Olle Eriksson Paul O’Callaghan Johan Kreuger An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting
description	Abstract Bioprinting is increasingly used to create complex tissue constructs for an array of research applications, and there are also increasing efforts to print tissues for transplantation. Bioprinting may also prove valuable in the context of drug screening for personalized medicine for treatment of diseases such as cancer. However, the rapidly expanding bioprinting research field is currently limited by access to bioprinters. To increase the availability of bioprinting technologies we present here an open source extrusion bioprinter based on the E3D motion system and tool changer to enable high-resolution multimaterial bioprinting. As proof of concept, the bioprinter is used to create collagen constructs using freeform reversible embedding of suspended hydrogels (FRESH) methodology, as well as multimaterial constructs composed of distinct sections of laminin and collagen. Data is presented demonstrating that the bioprinted constructs support growth of cells either seeded onto printed constructs or included in the bioink prior to bioprinting. This open source bioprinter is easily adapted for different bioprinting applications, and additional tools can be incorporated to increase the capabilities of the system.
format	article
author	Adam Engberg Christina Stelzl Olle Eriksson Paul O’Callaghan Johan Kreuger
author_facet	Adam Engberg Christina Stelzl Olle Eriksson Paul O’Callaghan Johan Kreuger
author_sort	Adam Engberg
title	An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting
title_short	An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting
title_full	An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting
title_fullStr	An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting
title_full_unstemmed	An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting
title_sort	open source extrusion bioprinter based on the e3d motion system and tool changer to enable fresh and multimaterial bioprinting
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea7f6922969646c992d59c4e42d5dff0
work_keys_str_mv	AT adamengberg anopensourceextrusionbioprinterbasedonthee3dmotionsystemandtoolchangertoenablefreshandmultimaterialbioprinting AT christinastelzl anopensourceextrusionbioprinterbasedonthee3dmotionsystemandtoolchangertoenablefreshandmultimaterialbioprinting AT olleeriksson anopensourceextrusionbioprinterbasedonthee3dmotionsystemandtoolchangertoenablefreshandmultimaterialbioprinting AT paulocallaghan anopensourceextrusionbioprinterbasedonthee3dmotionsystemandtoolchangertoenablefreshandmultimaterialbioprinting AT johankreuger anopensourceextrusionbioprinterbasedonthee3dmotionsystemandtoolchangertoenablefreshandmultimaterialbioprinting AT adamengberg opensourceextrusionbioprinterbasedonthee3dmotionsystemandtoolchangertoenablefreshandmultimaterialbioprinting AT christinastelzl opensourceextrusionbioprinterbasedonthee3dmotionsystemandtoolchangertoenablefreshandmultimaterialbioprinting AT olleeriksson opensourceextrusionbioprinterbasedonthee3dmotionsystemandtoolchangertoenablefreshandmultimaterialbioprinting AT paulocallaghan opensourceextrusionbioprinterbasedonthee3dmotionsystemandtoolchangertoenablefreshandmultimaterialbioprinting AT johankreuger opensourceextrusionbioprinterbasedonthee3dmotionsystemandtoolchangertoenablefreshandmultimaterialbioprinting
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An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting

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