Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis

Abstract Biocompatibility of hemodialysis (HD) systems have been considerably improved. However, mortality and morbidity rates of patients have remained high, raising questions regarding the biocompatibility of current systems. In the present study, 70 patients on regular HD (51 males; mean age, 63 ...

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Autores principales:	Taro Fukushi, Tae Yamamoto, Mai Yoshida, Emi Fujikura, Mariko Miyazaki, Masaaki Nakayama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea8096ac112e43268746480395284cea
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spelling	oai:doaj.org-article:ea8096ac112e43268746480395284cea2021-12-02T12:33:14ZEnhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis10.1038/s41598-020-78742-z2045-2322https://doaj.org/article/ea8096ac112e43268746480395284cea2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78742-zhttps://doaj.org/toc/2045-2322Abstract Biocompatibility of hemodialysis (HD) systems have been considerably improved. However, mortality and morbidity rates of patients have remained high, raising questions regarding the biocompatibility of current systems. In the present study, 70 patients on regular HD (51 males; mean age, 63 years; median duration of HD, 18 months) with high-performance membrane (polysulfone, 77%; polymethylmethacrylate, 23%) at Tohoku University Hospital were examined. Blood samples before and after HD, were subjected to measure apoptosis cells of white blood cells, plasma levels of the following molecules: myeloperoxidase (MPO), pentraxin 3 (PTX3), angiogenin, complements, and 17 cytokines. The main findings were as follows: significant decreases in leukocyte counts by dialysis, significant increases in apoptosis-positive leukocytes by dialysis (neutrophils and monocytes), and significant decrease in plasma angiogenin accompanying increase in plasma MPO and PTX3 levels, with no or only marginal changes in plasma pro-inflammatory cytokine levels and complement products by dialysis. The findings underlined the unsolved issue of bio-incompatibility of HD systems, and suggest the possible pathology of neutrophil apoptosis accompanying MPO release for the development of microinflammation in patients on HD.Taro FukushiTae YamamotoMai YoshidaEmi FujikuraMariko MiyazakiMasaaki NakayamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Taro Fukushi Tae Yamamoto Mai Yoshida Emi Fujikura Mariko Miyazaki Masaaki Nakayama Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
description	Abstract Biocompatibility of hemodialysis (HD) systems have been considerably improved. However, mortality and morbidity rates of patients have remained high, raising questions regarding the biocompatibility of current systems. In the present study, 70 patients on regular HD (51 males; mean age, 63 years; median duration of HD, 18 months) with high-performance membrane (polysulfone, 77%; polymethylmethacrylate, 23%) at Tohoku University Hospital were examined. Blood samples before and after HD, were subjected to measure apoptosis cells of white blood cells, plasma levels of the following molecules: myeloperoxidase (MPO), pentraxin 3 (PTX3), angiogenin, complements, and 17 cytokines. The main findings were as follows: significant decreases in leukocyte counts by dialysis, significant increases in apoptosis-positive leukocytes by dialysis (neutrophils and monocytes), and significant decrease in plasma angiogenin accompanying increase in plasma MPO and PTX3 levels, with no or only marginal changes in plasma pro-inflammatory cytokine levels and complement products by dialysis. The findings underlined the unsolved issue of bio-incompatibility of HD systems, and suggest the possible pathology of neutrophil apoptosis accompanying MPO release for the development of microinflammation in patients on HD.
format	article
author	Taro Fukushi Tae Yamamoto Mai Yoshida Emi Fujikura Mariko Miyazaki Masaaki Nakayama
author_facet	Taro Fukushi Tae Yamamoto Mai Yoshida Emi Fujikura Mariko Miyazaki Masaaki Nakayama
author_sort	Taro Fukushi
title	Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
title_short	Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
title_full	Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
title_fullStr	Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
title_full_unstemmed	Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
title_sort	enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ea8096ac112e43268746480395284cea
work_keys_str_mv	AT tarofukushi enhancedneutrophilapoptosisaccompanyingmyeloperoxidasereleaseduringhemodialysis AT taeyamamoto enhancedneutrophilapoptosisaccompanyingmyeloperoxidasereleaseduringhemodialysis AT maiyoshida enhancedneutrophilapoptosisaccompanyingmyeloperoxidasereleaseduringhemodialysis AT emifujikura enhancedneutrophilapoptosisaccompanyingmyeloperoxidasereleaseduringhemodialysis AT marikomiyazaki enhancedneutrophilapoptosisaccompanyingmyeloperoxidasereleaseduringhemodialysis AT masaakinakayama enhancedneutrophilapoptosisaccompanyingmyeloperoxidasereleaseduringhemodialysis
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Enhanced neutrophil apoptosis accompanying myeloperoxidase release during hemodialysis

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