Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

Small heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.

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Detalles Bibliográficos
Autores principales:	Rebecca Freilich, Miguel Betegon, Eric Tse, Sue-Ann Mok, Olivier Julien, David A. Agard, Daniel R. Southworth, Koh Takeuchi, Jason E. Gestwicki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea828c6ee26840cd8de08621cb5f0b7d
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spelling	oai:doaj.org-article:ea828c6ee26840cd8de08621cb5f0b7d2021-12-02T14:40:05ZCompeting protein-protein interactions regulate binding of Hsp27 to its client protein tau10.1038/s41467-018-07012-42041-1723https://doaj.org/article/ea828c6ee26840cd8de08621cb5f0b7d2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07012-4https://doaj.org/toc/2041-1723Small heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.Rebecca FreilichMiguel BetegonEric TseSue-Ann MokOlivier JulienDavid A. AgardDaniel R. SouthworthKoh TakeuchiJason E. GestwickiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca Freilich Miguel Betegon Eric Tse Sue-Ann Mok Olivier Julien David A. Agard Daniel R. Southworth Koh Takeuchi Jason E. Gestwicki Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
description	Small heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.
format	article
author	Rebecca Freilich Miguel Betegon Eric Tse Sue-Ann Mok Olivier Julien David A. Agard Daniel R. Southworth Koh Takeuchi Jason E. Gestwicki
author_facet	Rebecca Freilich Miguel Betegon Eric Tse Sue-Ann Mok Olivier Julien David A. Agard Daniel R. Southworth Koh Takeuchi Jason E. Gestwicki
author_sort	Rebecca Freilich
title	Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
title_short	Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
title_full	Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
title_fullStr	Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
title_full_unstemmed	Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
title_sort	competing protein-protein interactions regulate binding of hsp27 to its client protein tau
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ea828c6ee26840cd8de08621cb5f0b7d
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Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

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