THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS

Abstract. Peripheral blood monocytes were investigated in the patients with pulmonary tuberculosis. It was established that population of CD14+16+ monocytes was twofold increased in the patients with tuberculosis. The higher level of CD14+CD16+ monocytes was associated with decreasing number of mono...

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Autores principales:	L. V. Sakhno, M. A. Tihonova, V. S. Kozhevnikov, V. V. Senjukov, N. V. Pronkina, S. D. Nikonov, O. A. Zhdanov, A. A. Ostanin, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cd14+cd16+monocytes intracellular cytokines ppd–anergy pulmonary tuberculosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ea828fc8e6cb49fca53fd26c83a15e6c
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spelling	oai:doaj.org-article:ea828fc8e6cb49fca53fd26c83a15e6c2021-11-18T08:03:41ZTHE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2005-1-49-56https://doaj.org/article/ea828fc8e6cb49fca53fd26c83a15e6c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/423https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Peripheral blood monocytes were investigated in the patients with pulmonary tuberculosis. It was established that population of CD14+16+ monocytes was twofold increased in the patients with tuberculosis. The higher level of CD14+CD16+ monocytes was associated with decreasing number of monocytes with intracellular TNF–α, and negative correlation between these parameters was revealed. On the contrary, the higher level of CD14+CD16+ monocytes was connected with increased number of IL–10–producing monocytes. IL–10–producing cells were established mainly in the population of CD16+ monocytes and so population of CD14+CD16+ monocytes may represent the cells with suppressive activity. Really, the CD14+CD16+ monocytes were increased in patients with defective antigen specific response. Enhancement of CD14+CD16+ monocytes was observed in patients with active tuberculosis independently of form and dissemination of disease and did not connected with concomitant viral or bacterial infection. (Med. Immunol., 2005, vol.7, № 1, pp 49556)L. V. SakhnoM. A. TihonovaV. S. KozhevnikovV. V. SenjukovN. V. PronkinaS. D. NikonovO. A. ZhdanovA. A. OstaninE. R. ChernykhSPb RAACIarticlecd14+cd16+monocytesintracellular cytokinesppd–anergypulmonary tuberculosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 1, Pp 49-56 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cd14+cd16+monocytes intracellular cytokines ppd–anergy pulmonary tuberculosis Immunologic diseases. Allergy RC581-607
spellingShingle	cd14+cd16+monocytes intracellular cytokines ppd–anergy pulmonary tuberculosis Immunologic diseases. Allergy RC581-607 L. V. Sakhno M. A. Tihonova V. S. Kozhevnikov V. V. Senjukov N. V. Pronkina S. D. Nikonov O. A. Zhdanov A. A. Ostanin E. R. Chernykh THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
description	Abstract. Peripheral blood monocytes were investigated in the patients with pulmonary tuberculosis. It was established that population of CD14+16+ monocytes was twofold increased in the patients with tuberculosis. The higher level of CD14+CD16+ monocytes was associated with decreasing number of monocytes with intracellular TNF–α, and negative correlation between these parameters was revealed. On the contrary, the higher level of CD14+CD16+ monocytes was connected with increased number of IL–10–producing monocytes. IL–10–producing cells were established mainly in the population of CD16+ monocytes and so population of CD14+CD16+ monocytes may represent the cells with suppressive activity. Really, the CD14+CD16+ monocytes were increased in patients with defective antigen specific response. Enhancement of CD14+CD16+ monocytes was observed in patients with active tuberculosis independently of form and dissemination of disease and did not connected with concomitant viral or bacterial infection. (Med. Immunol., 2005, vol.7, № 1, pp 49556)
format	article
author	L. V. Sakhno M. A. Tihonova V. S. Kozhevnikov V. V. Senjukov N. V. Pronkina S. D. Nikonov O. A. Zhdanov A. A. Ostanin E. R. Chernykh
author_facet	L. V. Sakhno M. A. Tihonova V. S. Kozhevnikov V. V. Senjukov N. V. Pronkina S. D. Nikonov O. A. Zhdanov A. A. Ostanin E. R. Chernykh
author_sort	L. V. Sakhno
title	THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_short	THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_full	THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_fullStr	THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_full_unstemmed	THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_sort	phenotype and function of monocytes in patients with pulmonary tuberculosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/ea828fc8e6cb49fca53fd26c83a15e6c
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THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS

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