Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes

Infiltration of immune cells to the pancreatic islets precedes clinical symptoms of type 1 diabetes, and lack of methods to detect this insulitis impedes early interventions. Here the authors report a contrast enhanced ultrasound method that can detect early insulitis in mouse models of type 1 diabe...

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Autores principales:	David G. Ramirez, Eric Abenojar, Christopher Hernandez, David S. Lorberbaum, Lucine A. Papazian, Samantha Passman, Vinh Pham, Agata A. Exner, Richard K. P. Benninger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea834bcc10ac40038a26340fb8b2edc0
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spelling	oai:doaj.org-article:ea834bcc10ac40038a26340fb8b2edc02021-12-02T14:41:15ZContrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes10.1038/s41467-020-15957-82041-1723https://doaj.org/article/ea834bcc10ac40038a26340fb8b2edc02020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15957-8https://doaj.org/toc/2041-1723Infiltration of immune cells to the pancreatic islets precedes clinical symptoms of type 1 diabetes, and lack of methods to detect this insulitis impedes early interventions. Here the authors report a contrast enhanced ultrasound method that can detect early insulitis in mouse models of type 1 diabetes, based on increased microvascular permeability.David G. RamirezEric AbenojarChristopher HernandezDavid S. LorberbaumLucine A. PapazianSamantha PassmanVinh PhamAgata A. ExnerRichard K. P. BenningerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David G. Ramirez Eric Abenojar Christopher Hernandez David S. Lorberbaum Lucine A. Papazian Samantha Passman Vinh Pham Agata A. Exner Richard K. P. Benninger Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes
description	Infiltration of immune cells to the pancreatic islets precedes clinical symptoms of type 1 diabetes, and lack of methods to detect this insulitis impedes early interventions. Here the authors report a contrast enhanced ultrasound method that can detect early insulitis in mouse models of type 1 diabetes, based on increased microvascular permeability.
format	article
author	David G. Ramirez Eric Abenojar Christopher Hernandez David S. Lorberbaum Lucine A. Papazian Samantha Passman Vinh Pham Agata A. Exner Richard K. P. Benninger
author_facet	David G. Ramirez Eric Abenojar Christopher Hernandez David S. Lorberbaum Lucine A. Papazian Samantha Passman Vinh Pham Agata A. Exner Richard K. P. Benninger
author_sort	David G. Ramirez
title	Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes
title_short	Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes
title_full	Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes
title_fullStr	Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes
title_full_unstemmed	Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes
title_sort	contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ea834bcc10ac40038a26340fb8b2edc0
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Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes

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