Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells

Exposure to multiple pathogens is common in nature, yet interactions between the immune components targeting bacterial and viral pathogens during co-infection are poorly understood. Here the authors show that bacteria-derived LPS induces cytotoxic NK cells that suppress antiviral CD8 T cell response...

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Autores principales:	Tobias Straub, Marina A. Freudenberg, Ulrike Schleicher, Christian Bogdan, Georg Gasteiger, Hanspeter Pircher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea8d1ad39a4f4d37855579d39f274857
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spelling	oai:doaj.org-article:ea8d1ad39a4f4d37855579d39f2748572021-12-02T16:50:12ZBacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells10.1038/s41467-018-06609-z2041-1723https://doaj.org/article/ea8d1ad39a4f4d37855579d39f2748572018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06609-zhttps://doaj.org/toc/2041-1723Exposure to multiple pathogens is common in nature, yet interactions between the immune components targeting bacterial and viral pathogens during co-infection are poorly understood. Here the authors show that bacteria-derived LPS induces cytotoxic NK cells that suppress antiviral CD8 T cell response.Tobias StraubMarina A. FreudenbergUlrike SchleicherChristian BogdanGeorg GasteigerHanspeter PircherNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tobias Straub Marina A. Freudenberg Ulrike Schleicher Christian Bogdan Georg Gasteiger Hanspeter Pircher Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
description	Exposure to multiple pathogens is common in nature, yet interactions between the immune components targeting bacterial and viral pathogens during co-infection are poorly understood. Here the authors show that bacteria-derived LPS induces cytotoxic NK cells that suppress antiviral CD8 T cell response.
format	article
author	Tobias Straub Marina A. Freudenberg Ulrike Schleicher Christian Bogdan Georg Gasteiger Hanspeter Pircher
author_facet	Tobias Straub Marina A. Freudenberg Ulrike Schleicher Christian Bogdan Georg Gasteiger Hanspeter Pircher
author_sort	Tobias Straub
title	Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
title_short	Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
title_full	Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
title_fullStr	Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
title_full_unstemmed	Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
title_sort	bacterial coinfection restrains antiviral cd8 t-cell response via lps-induced inhibitory nk cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ea8d1ad39a4f4d37855579d39f274857
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Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells

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