Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats

The development of new laser-driven electron linear accelerators, providing unique ultrashort pulsed electron beams (UPEBs) with low repetition rates, opens new opportunities for radiotherapy and new fronts for radiobiological research in general. Considering the growing interest in the application...

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Autores principales:	Gohar Tsakanova, Nelly Babayan, Elena Karalova, Lina Hakobyan, Liana Abroyan, Aida Avetisyan, Hranush Avagyan, Sona Hakobyan, Arpine Poghosyan, Bagrat Baghdasaryan, Elina Arakelova, Violetta Ayvazyan, Lusine Matevosyan, Arpine Navasardyan, Hakob Davtyan, Lilit Apresyan, Arsham Yeremyan, Rouben Aroutiounian, Andreyan N. Osipov, Bagrat Grigoryan, Zaven Karalyan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	laser-driven ultrashort pulsed electron beam <i>Wistar</i> rats whole-body irradiation peripheral blood profiling bone marrow profiling lymph node profiling Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ea8d7c800bd741c3a6c5637ba2e61989
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spelling	oai:doaj.org-article:ea8d7c800bd741c3a6c5637ba2e619892021-11-11T16:59:22ZLow-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats10.3390/ijms2221115251422-00671661-6596https://doaj.org/article/ea8d7c800bd741c3a6c5637ba2e619892021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11525https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The development of new laser-driven electron linear accelerators, providing unique ultrashort pulsed electron beams (UPEBs) with low repetition rates, opens new opportunities for radiotherapy and new fronts for radiobiological research in general. Considering the growing interest in the application of UPEBs in radiation biology and medicine, the aim of this study was to reveal the changes in immune system in response to low-energy laser-driven UPEB whole-body irradiation in rodents. Forty male albino <i>Wistar</i> rats were exposed to laser-driven UPEB irradiation, after which different immunological parameters were studied on the 1st, 3rd, 7th, 14th, and 28th day after irradiation. According to the results, this type of irradiation induces alterations in the rat immune system, particularly by increasing the production of pro- and anti-inflammatory cytokines and elevating the DNA damage rate. Moreover, such an immune response reaches its maximal levels on the third day after laser-driven UPEB whole-body irradiation, showing partial recovery on subsequent days with a total recovery on the 28th day. The results of this study provide valuable insight into the effect of laser-driven UPEB whole-body irradiation on the immune system of the animals and support further animal experiments on the role of this novel type of irradiation.Gohar TsakanovaNelly BabayanElena KaralovaLina HakobyanLiana AbroyanAida AvetisyanHranush AvagyanSona HakobyanArpine PoghosyanBagrat BaghdasaryanElina ArakelovaVioletta AyvazyanLusine MatevosyanArpine NavasardyanHakob DavtyanLilit ApresyanArsham YeremyanRouben AroutiounianAndreyan N. OsipovBagrat GrigoryanZaven KaralyanMDPI AGarticlelaser-driven ultrashort pulsed electron beam<i>Wistar</i> ratswhole-body irradiationperipheral blood profilingbone marrow profilinglymph node profilingBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11525, p 11525 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	laser-driven ultrashort pulsed electron beam <i>Wistar</i> rats whole-body irradiation peripheral blood profiling bone marrow profiling lymph node profiling Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	laser-driven ultrashort pulsed electron beam <i>Wistar</i> rats whole-body irradiation peripheral blood profiling bone marrow profiling lymph node profiling Biology (General) QH301-705.5 Chemistry QD1-999 Gohar Tsakanova Nelly Babayan Elena Karalova Lina Hakobyan Liana Abroyan Aida Avetisyan Hranush Avagyan Sona Hakobyan Arpine Poghosyan Bagrat Baghdasaryan Elina Arakelova Violetta Ayvazyan Lusine Matevosyan Arpine Navasardyan Hakob Davtyan Lilit Apresyan Arsham Yeremyan Rouben Aroutiounian Andreyan N. Osipov Bagrat Grigoryan Zaven Karalyan Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
description	The development of new laser-driven electron linear accelerators, providing unique ultrashort pulsed electron beams (UPEBs) with low repetition rates, opens new opportunities for radiotherapy and new fronts for radiobiological research in general. Considering the growing interest in the application of UPEBs in radiation biology and medicine, the aim of this study was to reveal the changes in immune system in response to low-energy laser-driven UPEB whole-body irradiation in rodents. Forty male albino <i>Wistar</i> rats were exposed to laser-driven UPEB irradiation, after which different immunological parameters were studied on the 1st, 3rd, 7th, 14th, and 28th day after irradiation. According to the results, this type of irradiation induces alterations in the rat immune system, particularly by increasing the production of pro- and anti-inflammatory cytokines and elevating the DNA damage rate. Moreover, such an immune response reaches its maximal levels on the third day after laser-driven UPEB whole-body irradiation, showing partial recovery on subsequent days with a total recovery on the 28th day. The results of this study provide valuable insight into the effect of laser-driven UPEB whole-body irradiation on the immune system of the animals and support further animal experiments on the role of this novel type of irradiation.
format	article
author	Gohar Tsakanova Nelly Babayan Elena Karalova Lina Hakobyan Liana Abroyan Aida Avetisyan Hranush Avagyan Sona Hakobyan Arpine Poghosyan Bagrat Baghdasaryan Elina Arakelova Violetta Ayvazyan Lusine Matevosyan Arpine Navasardyan Hakob Davtyan Lilit Apresyan Arsham Yeremyan Rouben Aroutiounian Andreyan N. Osipov Bagrat Grigoryan Zaven Karalyan
author_facet	Gohar Tsakanova Nelly Babayan Elena Karalova Lina Hakobyan Liana Abroyan Aida Avetisyan Hranush Avagyan Sona Hakobyan Arpine Poghosyan Bagrat Baghdasaryan Elina Arakelova Violetta Ayvazyan Lusine Matevosyan Arpine Navasardyan Hakob Davtyan Lilit Apresyan Arsham Yeremyan Rouben Aroutiounian Andreyan N. Osipov Bagrat Grigoryan Zaven Karalyan
author_sort	Gohar Tsakanova
title	Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
title_short	Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
title_full	Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
title_fullStr	Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
title_full_unstemmed	Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
title_sort	low-energy laser-driven ultrashort pulsed electron beam irradiation-induced immune response in rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ea8d7c800bd741c3a6c5637ba2e61989
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Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats

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