Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

Antimicrobial peptide LL37 can bind nucleic acids and potentiate their sensing by endosomal TLRs. Here the authors show that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NETs via TLR8/13, suggesting that LL37 contribution...

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Autores principales:	Franziska Herster, Zsofia Bittner, Nathan K. Archer, Sabine Dickhöfer, David Eisel, Tatjana Eigenbrod, Thomas Knorpp, Nicole Schneiderhan-Marra, Markus W. Löffler, Hubert Kalbacher, Tim Vierbuchen, Holger Heine, Lloyd S. Miller, Dominik Hartl, Lukas Freund, Knut Schäkel, Martin Heister, Kamran Ghoreschi, Alexander N. R. Weber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea97f7082ce74177a2af8db079fd79c4
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spelling	oai:doaj.org-article:ea97f7082ce74177a2af8db079fd79c42021-12-02T17:32:59ZNeutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis10.1038/s41467-019-13756-42041-1723https://doaj.org/article/ea97f7082ce74177a2af8db079fd79c42020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13756-4https://doaj.org/toc/2041-1723Antimicrobial peptide LL37 can bind nucleic acids and potentiate their sensing by endosomal TLRs. Here the authors show that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NETs via TLR8/13, suggesting that LL37 contribution to psoriasis may be fueled by NET-associated RNA.Franziska HersterZsofia BittnerNathan K. ArcherSabine DickhöferDavid EiselTatjana EigenbrodThomas KnorppNicole Schneiderhan-MarraMarkus W. LöfflerHubert KalbacherTim VierbuchenHolger HeineLloyd S. MillerDominik HartlLukas FreundKnut SchäkelMartin HeisterKamran GhoreschiAlexander N. R. WeberNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Franziska Herster Zsofia Bittner Nathan K. Archer Sabine Dickhöfer David Eisel Tatjana Eigenbrod Thomas Knorpp Nicole Schneiderhan-Marra Markus W. Löffler Hubert Kalbacher Tim Vierbuchen Holger Heine Lloyd S. Miller Dominik Hartl Lukas Freund Knut Schäkel Martin Heister Kamran Ghoreschi Alexander N. R. Weber Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis
description	Antimicrobial peptide LL37 can bind nucleic acids and potentiate their sensing by endosomal TLRs. Here the authors show that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NETs via TLR8/13, suggesting that LL37 contribution to psoriasis may be fueled by NET-associated RNA.
format	article
author	Franziska Herster Zsofia Bittner Nathan K. Archer Sabine Dickhöfer David Eisel Tatjana Eigenbrod Thomas Knorpp Nicole Schneiderhan-Marra Markus W. Löffler Hubert Kalbacher Tim Vierbuchen Holger Heine Lloyd S. Miller Dominik Hartl Lukas Freund Knut Schäkel Martin Heister Kamran Ghoreschi Alexander N. R. Weber
author_facet	Franziska Herster Zsofia Bittner Nathan K. Archer Sabine Dickhöfer David Eisel Tatjana Eigenbrod Thomas Knorpp Nicole Schneiderhan-Marra Markus W. Löffler Hubert Kalbacher Tim Vierbuchen Holger Heine Lloyd S. Miller Dominik Hartl Lukas Freund Knut Schäkel Martin Heister Kamran Ghoreschi Alexander N. R. Weber
author_sort	Franziska Herster
title	Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis
title_short	Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis
title_full	Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis
title_fullStr	Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis
title_full_unstemmed	Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis
title_sort	neutrophil extracellular trap-associated rna and ll37 enable self-amplifying inflammation in psoriasis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ea97f7082ce74177a2af8db079fd79c4
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Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

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