Light Sensing in <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Highlights the Case for Establishing New Models for Fungal Photobiology

ABSTRACT Microbes inhabit diverse environmental locations, and many species need to shift their physiology between different niches. To do this effectively requires the accurate sensing of and response to the environment. For pathogens, exposure to light is one major change between a free-living sap...

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Autor principal:	Alexander Idnurm
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/ea98afbf7b174645b0722f025d299e29
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spelling	oai:doaj.org-article:ea98afbf7b174645b0722f025d299e292021-11-15T15:40:06ZLight Sensing in <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Highlights the Case for Establishing New Models for Fungal Photobiology10.1128/mBio.00260-132150-7511https://doaj.org/article/ea98afbf7b174645b0722f025d299e292013-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00260-13https://doaj.org/toc/2150-7511ABSTRACT Microbes inhabit diverse environmental locations, and many species need to shift their physiology between different niches. To do this effectively requires the accurate sensing of and response to the environment. For pathogens, exposure to light is one major change between a free-living saprophyte lifestyle and causation of disease within the host. However, how light may act as a signal to influence pathogenesis, on the side of either the host or the pathogen, is poorly understood. Research during the last 2 decades has uncovered aspects about the machinery for light sensing in a small number of fungi. Now, Fuller et al. have initiated studies into the role that light and two photosensor homologs play in the behavior of the ubiquitous fungal pathogen Aspergillus fumigatus [K. K. Fuller, C. S. Ringelberg, J. J. Loros, and J. C. Dunlap, mBio 4(2):e00142-13, 2013, doi:10.1128/mBio.00142-13]. Light represses the germination of A. fumigatus spores and enhances resistance to ultraviolet light, oxidative stresses, and cell wall perturbations. The phenotypes of the strains with mutations in the LreA and FphA homologs revealed that these sensors control some, but not all, responses to light. Furthermore, interactions occur between blue and red light signaling pathways, as has been described for a related saprophytic species, Aspergillus nidulans. Genome-wide transcript analyses found that about 2.6% of genes increase or decrease their transcript levels in response to light. This use of A. fumigatus establishes common elements between model filamentous species and pathogenic species, underscoring the benefits of extending photobiology to new species of fungi.Alexander IdnurmAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 3 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Alexander Idnurm Light Sensing in <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Highlights the Case for Establishing New Models for Fungal Photobiology
description	ABSTRACT Microbes inhabit diverse environmental locations, and many species need to shift their physiology between different niches. To do this effectively requires the accurate sensing of and response to the environment. For pathogens, exposure to light is one major change between a free-living saprophyte lifestyle and causation of disease within the host. However, how light may act as a signal to influence pathogenesis, on the side of either the host or the pathogen, is poorly understood. Research during the last 2 decades has uncovered aspects about the machinery for light sensing in a small number of fungi. Now, Fuller et al. have initiated studies into the role that light and two photosensor homologs play in the behavior of the ubiquitous fungal pathogen Aspergillus fumigatus [K. K. Fuller, C. S. Ringelberg, J. J. Loros, and J. C. Dunlap, mBio 4(2):e00142-13, 2013, doi:10.1128/mBio.00142-13]. Light represses the germination of A. fumigatus spores and enhances resistance to ultraviolet light, oxidative stresses, and cell wall perturbations. The phenotypes of the strains with mutations in the LreA and FphA homologs revealed that these sensors control some, but not all, responses to light. Furthermore, interactions occur between blue and red light signaling pathways, as has been described for a related saprophytic species, Aspergillus nidulans. Genome-wide transcript analyses found that about 2.6% of genes increase or decrease their transcript levels in response to light. This use of A. fumigatus establishes common elements between model filamentous species and pathogenic species, underscoring the benefits of extending photobiology to new species of fungi.
format	article
author	Alexander Idnurm
author_facet	Alexander Idnurm
author_sort	Alexander Idnurm
title	Light Sensing in <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Highlights the Case for Establishing New Models for Fungal Photobiology
title_short	Light Sensing in <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Highlights the Case for Establishing New Models for Fungal Photobiology
title_full	Light Sensing in <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Highlights the Case for Establishing New Models for Fungal Photobiology
title_fullStr	Light Sensing in <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Highlights the Case for Establishing New Models for Fungal Photobiology
title_full_unstemmed	Light Sensing in <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Highlights the Case for Establishing New Models for Fungal Photobiology
title_sort	light sensing in <named-content content-type="genus-species">aspergillus fumigatus</named-content> highlights the case for establishing new models for fungal photobiology
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/ea98afbf7b174645b0722f025d299e29
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Light Sensing in <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Highlights the Case for Establishing New Models for Fungal Photobiology

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