Human herpesvirus 6 and epilepsy

Abstract We investigated the association between human herpesvirus 6 (HHV‐6) and mesial temporal sclerosis (MTS) in 87 patients who had surgery for drug‐resistant epilepsy. Fifty‐four had MTS, 22 focal cortical dysplasia (FCD), four tumors, three vascular malformations, and three a history of enceph...

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Autores principales:	William H. Theodore, Emily Leibovitch, Bridgette J. Billioux, Sara K. Inati, Kareem Zaghloul, John Heiss, William D. Gaillard, Steven Jacobson
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	focal epilepsy HHV‐6 mesial temporal sclerosis Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ea9c2ef5a94f42dbb5e07d5bb9913093
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spelling	oai:doaj.org-article:ea9c2ef5a94f42dbb5e07d5bb99130932021-12-01T06:09:19ZHuman herpesvirus 6 and epilepsy2470-923910.1002/epi4.12531https://doaj.org/article/ea9c2ef5a94f42dbb5e07d5bb99130932021-12-01T00:00:00Zhttps://doi.org/10.1002/epi4.12531https://doaj.org/toc/2470-9239Abstract We investigated the association between human herpesvirus 6 (HHV‐6) and mesial temporal sclerosis (MTS) in 87 patients who had surgery for drug‐resistant epilepsy. Fifty‐four had MTS, 22 focal cortical dysplasia (FCD), four tumors, three vascular malformations, and three a history of encephalitis. We extracted DNA from fresh brain tissue immediately after surgery and performed viral detection with quantitative real‐time polymerase chain reaction (PCR) or digital droplet PCR specific for HHV‐6A and HHV‐6B. Tissue was studied with standard clinical techniques, including hematoxylin and eosin, glial fibrillary acidic protein, and NeuN stains. Twenty‐nine of 54 patients with MTS, six of 23 with focal cortical dysplasia (FCD), and one of three with a history of encephalitis were positive for HHV‐6 (P < .02). Febrile seizure history was not associated with HHV‐6 detection. Patients with MTS had significantly lower seizure onset age than those with other pathologies. Thirteen patients had positron emission tomography with [11C]PBR28, a marker for reactive astrocytes and activated microglia; there was a trend for HHV‐6‐positive patients to have higher binding in their seizure foci, suggesting inflammation. Our study supports a potential role for HHV‐6 in the etiology of MTS.William H. TheodoreEmily LeibovitchBridgette J. BilliouxSara K. InatiKareem ZaghloulJohn HeissWilliam D. GaillardSteven JacobsonWileyarticlefocal epilepsyHHV‐6mesial temporal sclerosisNeurology. Diseases of the nervous systemRC346-429ENEpilepsia Open, Vol 6, Iss 4, Pp 777-780 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	focal epilepsy HHV‐6 mesial temporal sclerosis Neurology. Diseases of the nervous system RC346-429
spellingShingle	focal epilepsy HHV‐6 mesial temporal sclerosis Neurology. Diseases of the nervous system RC346-429 William H. Theodore Emily Leibovitch Bridgette J. Billioux Sara K. Inati Kareem Zaghloul John Heiss William D. Gaillard Steven Jacobson Human herpesvirus 6 and epilepsy
description	Abstract We investigated the association between human herpesvirus 6 (HHV‐6) and mesial temporal sclerosis (MTS) in 87 patients who had surgery for drug‐resistant epilepsy. Fifty‐four had MTS, 22 focal cortical dysplasia (FCD), four tumors, three vascular malformations, and three a history of encephalitis. We extracted DNA from fresh brain tissue immediately after surgery and performed viral detection with quantitative real‐time polymerase chain reaction (PCR) or digital droplet PCR specific for HHV‐6A and HHV‐6B. Tissue was studied with standard clinical techniques, including hematoxylin and eosin, glial fibrillary acidic protein, and NeuN stains. Twenty‐nine of 54 patients with MTS, six of 23 with focal cortical dysplasia (FCD), and one of three with a history of encephalitis were positive for HHV‐6 (P < .02). Febrile seizure history was not associated with HHV‐6 detection. Patients with MTS had significantly lower seizure onset age than those with other pathologies. Thirteen patients had positron emission tomography with [11C]PBR28, a marker for reactive astrocytes and activated microglia; there was a trend for HHV‐6‐positive patients to have higher binding in their seizure foci, suggesting inflammation. Our study supports a potential role for HHV‐6 in the etiology of MTS.
format	article
author	William H. Theodore Emily Leibovitch Bridgette J. Billioux Sara K. Inati Kareem Zaghloul John Heiss William D. Gaillard Steven Jacobson
author_facet	William H. Theodore Emily Leibovitch Bridgette J. Billioux Sara K. Inati Kareem Zaghloul John Heiss William D. Gaillard Steven Jacobson
author_sort	William H. Theodore
title	Human herpesvirus 6 and epilepsy
title_short	Human herpesvirus 6 and epilepsy
title_full	Human herpesvirus 6 and epilepsy
title_fullStr	Human herpesvirus 6 and epilepsy
title_full_unstemmed	Human herpesvirus 6 and epilepsy
title_sort	human herpesvirus 6 and epilepsy
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/ea9c2ef5a94f42dbb5e07d5bb9913093
work_keys_str_mv	AT williamhtheodore humanherpesvirus6andepilepsy AT emilyleibovitch humanherpesvirus6andepilepsy AT bridgettejbillioux humanherpesvirus6andepilepsy AT sarakinati humanherpesvirus6andepilepsy AT kareemzaghloul humanherpesvirus6andepilepsy AT johnheiss humanherpesvirus6andepilepsy AT williamdgaillard humanherpesvirus6andepilepsy AT stevenjacobson humanherpesvirus6andepilepsy
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Human herpesvirus 6 and epilepsy

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