Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?

Graeme Jones, Erica Darian-Smith, Michael Kwok, Tania WinzenbergMenzies Research Institute, University of Tasmania, Tasmania, AustraliaAbstract: There have been substantial advances in the treatment of rheumatoid arthritis in recent years. Traditional disease-modifying antirheumatic drugs (DMARDs) h...

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Autores principales:	Jones G, Darian-Smith E, Kwok M, Winzenberg T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eaa164dc94464baa9bc2ed68996b4070
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spelling	oai:doaj.org-article:eaa164dc94464baa9bc2ed68996b40702021-12-02T01:27:20ZEffect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?1177-54751177-5491https://doaj.org/article/eaa164dc94464baa9bc2ed68996b40702012-07-01T00:00:00Zhttp://www.dovepress.com/effect-of-biologic-therapy-on-radiological-progression-in-rheumatoid-a-a10281https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Graeme Jones, Erica Darian-Smith, Michael Kwok, Tania WinzenbergMenzies Research Institute, University of Tasmania, Tasmania, AustraliaAbstract: There have been substantial advances in the treatment of rheumatoid arthritis in recent years. Traditional disease-modifying antirheumatic drugs (DMARDs) have been shown to have small effects on the progression of radiographic damage. This quantitative overview summarizes the evidence for biologic DMARDS and radiographic damage either alone or in combination with methotrexate. Two outcomes were used (standardized mean difference and odds of progression). A total of 21 trials were identified of which 18 had useable data. For biologic monotherapy, tocilizumab, adalimumab, and etanercept were significantly better than methotrexate, with tocilizumab ranking first in both outcomes while golimumab was ineffective in both outcomes. For a biologic in combination with methotrexate compared with methotrexate alone, most therapies studied (etanercept, adalimumab, infliximab, certolizumab, tocilizumab, and rituximab) were effective at slowing X-ray progression using either outcome, with infliximab ranking first in both outcomes. The exceptions to this were golimumab (no effect on standardized mean difference) and abatacept (no effect on odds of progression). This effect was additional to methotrexate; thus, the overall benefit is moderate to large in magnitude, which is clearly of major clinical significance for sufferers of rheumatoid arthritis and supports the use of biologic DMARDs in those with a poor disease prognosis.Keywords: rheumatoid, trials, meta-analysis, radiographs, biologic, disease-modifying antirheumatic drugs, DMARDsJones GDarian-Smith EKwok MWinzenberg TDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2012, Iss default, Pp 155-161 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jones G Darian-Smith E Kwok M Winzenberg T Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?
description	Graeme Jones, Erica Darian-Smith, Michael Kwok, Tania WinzenbergMenzies Research Institute, University of Tasmania, Tasmania, AustraliaAbstract: There have been substantial advances in the treatment of rheumatoid arthritis in recent years. Traditional disease-modifying antirheumatic drugs (DMARDs) have been shown to have small effects on the progression of radiographic damage. This quantitative overview summarizes the evidence for biologic DMARDS and radiographic damage either alone or in combination with methotrexate. Two outcomes were used (standardized mean difference and odds of progression). A total of 21 trials were identified of which 18 had useable data. For biologic monotherapy, tocilizumab, adalimumab, and etanercept were significantly better than methotrexate, with tocilizumab ranking first in both outcomes while golimumab was ineffective in both outcomes. For a biologic in combination with methotrexate compared with methotrexate alone, most therapies studied (etanercept, adalimumab, infliximab, certolizumab, tocilizumab, and rituximab) were effective at slowing X-ray progression using either outcome, with infliximab ranking first in both outcomes. The exceptions to this were golimumab (no effect on standardized mean difference) and abatacept (no effect on odds of progression). This effect was additional to methotrexate; thus, the overall benefit is moderate to large in magnitude, which is clearly of major clinical significance for sufferers of rheumatoid arthritis and supports the use of biologic DMARDs in those with a poor disease prognosis.Keywords: rheumatoid, trials, meta-analysis, radiographs, biologic, disease-modifying antirheumatic drugs, DMARDs
format	article
author	Jones G Darian-Smith E Kwok M Winzenberg T
author_facet	Jones G Darian-Smith E Kwok M Winzenberg T
author_sort	Jones G
title	Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?
title_short	Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?
title_full	Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?
title_fullStr	Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?
title_full_unstemmed	Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?
title_sort	effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/eaa164dc94464baa9bc2ed68996b4070
work_keys_str_mv	AT jonesg effectofbiologictherapyonradiologicalprogressioninrheumatoidarthritiswhatdoesitaddtomethotrexate AT dariansmithe effectofbiologictherapyonradiologicalprogressioninrheumatoidarthritiswhatdoesitaddtomethotrexate AT kwokm effectofbiologictherapyonradiologicalprogressioninrheumatoidarthritiswhatdoesitaddtomethotrexate AT winzenbergt effectofbiologictherapyonradiologicalprogressioninrheumatoidarthritiswhatdoesitaddtomethotrexate
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Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?

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