Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals
There is crosstalk between the maintenance of DNA methylation and histone methylation. Here, the authors create an Uhrf1 knockin mouse model that abolishes the H3K9me2/3-binding activity of Uhrf1, and show that DNA maintenance methylation in mammals is largely independent of H3K9 methylation.
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Nature Portfolio
2016
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oai:doaj.org-article:eaa46b60799b4bfabd64eeb76e38f5dd2021-12-02T14:39:12ZDissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals10.1038/ncomms124642041-1723https://doaj.org/article/eaa46b60799b4bfabd64eeb76e38f5dd2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12464https://doaj.org/toc/2041-1723There is crosstalk between the maintenance of DNA methylation and histone methylation. Here, the authors create an Uhrf1 knockin mouse model that abolishes the H3K9me2/3-binding activity of Uhrf1, and show that DNA maintenance methylation in mammals is largely independent of H3K9 methylation.Qian ZhaoJiqin ZhangRuoyu ChenLina WangBo LiHao ChengXiaoya DuanHaijun ZhuWei WeiJiwen LiQihan WuJing-Dong J. HanWenqiang YuShaorong GaoGuohong LiJiemin WongNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Qian Zhao Jiqin Zhang Ruoyu Chen Lina Wang Bo Li Hao Cheng Xiaoya Duan Haijun Zhu Wei Wei Jiwen Li Qihan Wu Jing-Dong J. Han Wenqiang Yu Shaorong Gao Guohong Li Jiemin Wong Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals |
| description |
There is crosstalk between the maintenance of DNA methylation and histone methylation. Here, the authors create an Uhrf1 knockin mouse model that abolishes the H3K9me2/3-binding activity of Uhrf1, and show that DNA maintenance methylation in mammals is largely independent of H3K9 methylation. |
| format |
article |
| author |
Qian Zhao Jiqin Zhang Ruoyu Chen Lina Wang Bo Li Hao Cheng Xiaoya Duan Haijun Zhu Wei Wei Jiwen Li Qihan Wu Jing-Dong J. Han Wenqiang Yu Shaorong Gao Guohong Li Jiemin Wong |
| author_facet |
Qian Zhao Jiqin Zhang Ruoyu Chen Lina Wang Bo Li Hao Cheng Xiaoya Duan Haijun Zhu Wei Wei Jiwen Li Qihan Wu Jing-Dong J. Han Wenqiang Yu Shaorong Gao Guohong Li Jiemin Wong |
| author_sort |
Qian Zhao |
| title |
Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals |
| title_short |
Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals |
| title_full |
Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals |
| title_fullStr |
Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals |
| title_full_unstemmed |
Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals |
| title_sort |
dissecting the precise role of h3k9 methylation in crosstalk with dna maintenance methylation in mammals |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/eaa46b60799b4bfabd64eeb76e38f5dd |
| work_keys_str_mv |
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