Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes

Abstract Early microvascular damage in diabetes (e.g. capillary nonperfusion and ischemia) can now be assessed and quantified with optical coherence tomography-angiography (OCT-A). The morphology of vascular tissue is indeed affected by different factors; however, there is a paucity of data examinin...

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Autores principales:	Fang Yao Tang, Danny S. Ng, Alexander Lam, Fiona Luk, Raymond Wong, Carmen Chan, Shaheeda Mohamed, Angie Fong, Jerry Lok, Tiffany Tso, Frank Lai, Marten Brelen, Tien Y. Wong, Clement C. Tham, Carol Y. Cheung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eaaa3ec57c364528a75a5aac23b0fb95
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spelling	oai:doaj.org-article:eaaa3ec57c364528a75a5aac23b0fb952021-12-02T15:05:01ZDeterminants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes10.1038/s41598-017-02767-02045-2322https://doaj.org/article/eaaa3ec57c364528a75a5aac23b0fb952017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02767-0https://doaj.org/toc/2045-2322Abstract Early microvascular damage in diabetes (e.g. capillary nonperfusion and ischemia) can now be assessed and quantified with optical coherence tomography-angiography (OCT-A). The morphology of vascular tissue is indeed affected by different factors; however, there is a paucity of data examining whether OCT-A metrics are influenced by ocular, systemic and demographic variables in subjects with diabetes. We conducted an observational cross-sectional study and included 434 eyes from 286 patients with diabetes. Foveal avascular zone (FAZ) area, FAZ circularity, total and parafoveal vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI) from the superficial capillary plexus OCT-angiogram were measured by a customized automated image analysis program. We found that diabetic retinopathy (DR) severity was associated with increased FAZ area, decreased FAZ circularity, lower VD, lower FD, and increased VDI. Enlarged FAZ area was correlated with shorter axial length and thinner central subfield macular thickness. Decreased FAZ circularity was correlated with a reduction in visual function. Decreased VD was correlated with thinner macular ganglion-cell inner plexiform layer. Increased VDI was correlated with higher fasting glucose level. We concluded that the effects of ocular and systemic factors in diabetics should be taken into consideration when assessing microvascular alterations via OCT-A.Fang Yao TangDanny S. NgAlexander LamFiona LukRaymond WongCarmen ChanShaheeda MohamedAngie FongJerry LokTiffany TsoFrank LaiMarten BrelenTien Y. WongClement C. ThamCarol Y. CheungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fang Yao Tang Danny S. Ng Alexander Lam Fiona Luk Raymond Wong Carmen Chan Shaheeda Mohamed Angie Fong Jerry Lok Tiffany Tso Frank Lai Marten Brelen Tien Y. Wong Clement C. Tham Carol Y. Cheung Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes
description	Abstract Early microvascular damage in diabetes (e.g. capillary nonperfusion and ischemia) can now be assessed and quantified with optical coherence tomography-angiography (OCT-A). The morphology of vascular tissue is indeed affected by different factors; however, there is a paucity of data examining whether OCT-A metrics are influenced by ocular, systemic and demographic variables in subjects with diabetes. We conducted an observational cross-sectional study and included 434 eyes from 286 patients with diabetes. Foveal avascular zone (FAZ) area, FAZ circularity, total and parafoveal vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI) from the superficial capillary plexus OCT-angiogram were measured by a customized automated image analysis program. We found that diabetic retinopathy (DR) severity was associated with increased FAZ area, decreased FAZ circularity, lower VD, lower FD, and increased VDI. Enlarged FAZ area was correlated with shorter axial length and thinner central subfield macular thickness. Decreased FAZ circularity was correlated with a reduction in visual function. Decreased VD was correlated with thinner macular ganglion-cell inner plexiform layer. Increased VDI was correlated with higher fasting glucose level. We concluded that the effects of ocular and systemic factors in diabetics should be taken into consideration when assessing microvascular alterations via OCT-A.
format	article
author	Fang Yao Tang Danny S. Ng Alexander Lam Fiona Luk Raymond Wong Carmen Chan Shaheeda Mohamed Angie Fong Jerry Lok Tiffany Tso Frank Lai Marten Brelen Tien Y. Wong Clement C. Tham Carol Y. Cheung
author_facet	Fang Yao Tang Danny S. Ng Alexander Lam Fiona Luk Raymond Wong Carmen Chan Shaheeda Mohamed Angie Fong Jerry Lok Tiffany Tso Frank Lai Marten Brelen Tien Y. Wong Clement C. Tham Carol Y. Cheung
author_sort	Fang Yao Tang
title	Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes
title_short	Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes
title_full	Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes
title_fullStr	Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes
title_full_unstemmed	Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes
title_sort	determinants of quantitative optical coherence tomography angiography metrics in patients with diabetes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/eaaa3ec57c364528a75a5aac23b0fb95
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Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes

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