FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH ATHEROSCLEROSIS

Our study included measuring the following biological substances: cytokines (IL-1β, IL-6, IFNγ, TNFα, IL-10, TGF-β1, TGF-β2, IL-2, IL-17); soluble receptors to cytokines (IL-2R, IL-6R, TNFαRI and TNFαRII); total serum cholesterol; indicators of intercellular matrix degradation (metalproteinases-9; t...

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Autores principales:	E. P. Turmova, E. V. Markelova, A. A. Silayev, P. A. Lukyanov, I. V. Chikalovets
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	atherosclerosis immune system hyperlipidemiya cytokines metalloproteinases Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/eaacbfcd4aef4d5d9bbd2342b03af7b5
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spelling	oai:doaj.org-article:eaacbfcd4aef4d5d9bbd2342b03af7b52021-11-18T08:03:44ZFEATURES OF CYTOKINE PROFILE IN PATIENTS WITH ATHEROSCLEROSIS1563-06252313-741X10.15789/1563-0625-2014-4-323-332https://doaj.org/article/eaacbfcd4aef4d5d9bbd2342b03af7b52014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/698https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XOur study included measuring the following biological substances: cytokines (IL-1β, IL-6, IFNγ, TNFα, IL-10, TGF-β1, TGF-β2, IL-2, IL-17); soluble receptors to cytokines (IL-2R, IL-6R, TNFαRI and TNFαRII); total serum cholesterol; indicators of intercellular matrix degradation (metalproteinases-9; tissular inhibitor of MMP-9 1 type (TIMP-1); MMP-9/TIMP 1 and MMP-9/TIMP 2 complexes) in 260 patients with clinically manifestations of coronary and lower limb atherosclerosis. Among the patients with atherosclerosis, we have found increased average levels of IL-6, TGF-β2, TNFα RI, TNFαRII, IL-2R, along with decreased IL-2 and IL-10 concentrations, increase of MMP-9/TIMP-2 ratio in blood serum. The following direct correlations were revealed between MMP-9 and IL-1β; between MMP-9/TIMP-1 complex and IL-1β, IL-2, IL-2R, IL-17, IL-10; TIMP-1 with TNFα, IL-2 and IL-2R. At high levels of the general cholesterol, an increased production of TNFα, IL-17, TGF-β1, IL-2, IL-10, MMP-9, TIMP-1 was detected, as well as decreased amounts of TNFα I and TNFαII soluble receptors in blood serum of these patients.Direct correlations were established between total blood cholesterol levels and IL-2, IFNγ, MMP- 9, TIMP-1, MMP-9/TIMP-2. However blood cholesterol levels showed reverse correlations with TNFαRI, and TNFαRII.In the course of this study, we have specified a functional imbalance between pro- and anti-inflammatory mechanisms of immune reaction in clinically expressed atherosclerosis. Significant regulatory interactions have been revealed between cytokine levels, total blood cholesterol and markers of intercellular matrix degradation.E. P. TurmovaE. V. MarkelovaA. A. SilayevP. A. LukyanovI. V. ChikalovetsSPb RAACIarticleatherosclerosisimmune systemhyperlipidemiyacytokinesmetalloproteinasesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 4, Pp 323-332 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	atherosclerosis immune system hyperlipidemiya cytokines metalloproteinases Immunologic diseases. Allergy RC581-607
spellingShingle	atherosclerosis immune system hyperlipidemiya cytokines metalloproteinases Immunologic diseases. Allergy RC581-607 E. P. Turmova E. V. Markelova A. A. Silayev P. A. Lukyanov I. V. Chikalovets FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH ATHEROSCLEROSIS
description	Our study included measuring the following biological substances: cytokines (IL-1β, IL-6, IFNγ, TNFα, IL-10, TGF-β1, TGF-β2, IL-2, IL-17); soluble receptors to cytokines (IL-2R, IL-6R, TNFαRI and TNFαRII); total serum cholesterol; indicators of intercellular matrix degradation (metalproteinases-9; tissular inhibitor of MMP-9 1 type (TIMP-1); MMP-9/TIMP 1 and MMP-9/TIMP 2 complexes) in 260 patients with clinically manifestations of coronary and lower limb atherosclerosis. Among the patients with atherosclerosis, we have found increased average levels of IL-6, TGF-β2, TNFα RI, TNFαRII, IL-2R, along with decreased IL-2 and IL-10 concentrations, increase of MMP-9/TIMP-2 ratio in blood serum. The following direct correlations were revealed between MMP-9 and IL-1β; between MMP-9/TIMP-1 complex and IL-1β, IL-2, IL-2R, IL-17, IL-10; TIMP-1 with TNFα, IL-2 and IL-2R. At high levels of the general cholesterol, an increased production of TNFα, IL-17, TGF-β1, IL-2, IL-10, MMP-9, TIMP-1 was detected, as well as decreased amounts of TNFα I and TNFαII soluble receptors in blood serum of these patients.Direct correlations were established between total blood cholesterol levels and IL-2, IFNγ, MMP- 9, TIMP-1, MMP-9/TIMP-2. However blood cholesterol levels showed reverse correlations with TNFαRI, and TNFαRII.In the course of this study, we have specified a functional imbalance between pro- and anti-inflammatory mechanisms of immune reaction in clinically expressed atherosclerosis. Significant regulatory interactions have been revealed between cytokine levels, total blood cholesterol and markers of intercellular matrix degradation.
format	article
author	E. P. Turmova E. V. Markelova A. A. Silayev P. A. Lukyanov I. V. Chikalovets
author_facet	E. P. Turmova E. V. Markelova A. A. Silayev P. A. Lukyanov I. V. Chikalovets
author_sort	E. P. Turmova
title	FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH ATHEROSCLEROSIS
title_short	FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH ATHEROSCLEROSIS
title_full	FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH ATHEROSCLEROSIS
title_fullStr	FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH ATHEROSCLEROSIS
title_full_unstemmed	FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH ATHEROSCLEROSIS
title_sort	features of cytokine profile in patients with atherosclerosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/eaacbfcd4aef4d5d9bbd2342b03af7b5
work_keys_str_mv	AT epturmova featuresofcytokineprofileinpatientswithatherosclerosis AT evmarkelova featuresofcytokineprofileinpatientswithatherosclerosis AT aasilayev featuresofcytokineprofileinpatientswithatherosclerosis AT palukyanov featuresofcytokineprofileinpatientswithatherosclerosis AT ivchikalovets featuresofcytokineprofileinpatientswithatherosclerosis
_version_	1718422454059139072

FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH ATHEROSCLEROSIS

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