Intracochlear distortion products are broadly generated by outer hair cells but their contributions to otoacoustic emissions are spatially restricted

Abstract Detection of low-level sounds by the mammalian cochlea requires electromechanical feedback from outer hair cells (OHCs). This feedback arises due to the electromotile response of OHCs, which is driven by the modulation of their receptor potential caused by the stimulation of mechano-sensiti...

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Autores principales:	Thomas Bowling, Haiqi Wen, Sebastiaan W. F. Meenderink, Wei Dong, Julien Meaud
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eaae1e4c92884ec380ca5fb8a74988f5
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spelling	oai:doaj.org-article:eaae1e4c92884ec380ca5fb8a74988f52021-12-02T18:18:51ZIntracochlear distortion products are broadly generated by outer hair cells but their contributions to otoacoustic emissions are spatially restricted10.1038/s41598-021-93099-72045-2322https://doaj.org/article/eaae1e4c92884ec380ca5fb8a74988f52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93099-7https://doaj.org/toc/2045-2322Abstract Detection of low-level sounds by the mammalian cochlea requires electromechanical feedback from outer hair cells (OHCs). This feedback arises due to the electromotile response of OHCs, which is driven by the modulation of their receptor potential caused by the stimulation of mechano-sensitive ion channels. Nonlinearity in these channels distorts impinging sounds, creating distortion-products that are detectable in the ear canal as distortion-product otoacoustic emissions (DPOAEs). Ongoing efforts aim to develop DPOAEs, which reflects the ear’s health, into diagnostic tools for sensory hearing loss. These efforts are hampered by limited knowledge on the cochlear extent contributing to DPOAEs. Here, we report on intracochlear distortion products (IDPs) in OHC electrical responses and intracochlear fluid pressures. Experiments and simulations with a physiologically motivated cochlear model show that widely generated electrical IDPs lead to mechanical vibrations in a frequency-dependent manner. The local cochlear impedance restricts the region from which IDPs contribute to DPOAEs at low to moderate intensity, which suggests that DPOAEs may be used clinically to provide location-specific information about cochlear damage.Thomas BowlingHaiqi WenSebastiaan W. F. MeenderinkWei DongJulien MeaudNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas Bowling Haiqi Wen Sebastiaan W. F. Meenderink Wei Dong Julien Meaud Intracochlear distortion products are broadly generated by outer hair cells but their contributions to otoacoustic emissions are spatially restricted
description	Abstract Detection of low-level sounds by the mammalian cochlea requires electromechanical feedback from outer hair cells (OHCs). This feedback arises due to the electromotile response of OHCs, which is driven by the modulation of their receptor potential caused by the stimulation of mechano-sensitive ion channels. Nonlinearity in these channels distorts impinging sounds, creating distortion-products that are detectable in the ear canal as distortion-product otoacoustic emissions (DPOAEs). Ongoing efforts aim to develop DPOAEs, which reflects the ear’s health, into diagnostic tools for sensory hearing loss. These efforts are hampered by limited knowledge on the cochlear extent contributing to DPOAEs. Here, we report on intracochlear distortion products (IDPs) in OHC electrical responses and intracochlear fluid pressures. Experiments and simulations with a physiologically motivated cochlear model show that widely generated electrical IDPs lead to mechanical vibrations in a frequency-dependent manner. The local cochlear impedance restricts the region from which IDPs contribute to DPOAEs at low to moderate intensity, which suggests that DPOAEs may be used clinically to provide location-specific information about cochlear damage.
format	article
author	Thomas Bowling Haiqi Wen Sebastiaan W. F. Meenderink Wei Dong Julien Meaud
author_facet	Thomas Bowling Haiqi Wen Sebastiaan W. F. Meenderink Wei Dong Julien Meaud
author_sort	Thomas Bowling
title	Intracochlear distortion products are broadly generated by outer hair cells but their contributions to otoacoustic emissions are spatially restricted
title_short	Intracochlear distortion products are broadly generated by outer hair cells but their contributions to otoacoustic emissions are spatially restricted
title_full	Intracochlear distortion products are broadly generated by outer hair cells but their contributions to otoacoustic emissions are spatially restricted
title_fullStr	Intracochlear distortion products are broadly generated by outer hair cells but their contributions to otoacoustic emissions are spatially restricted
title_full_unstemmed	Intracochlear distortion products are broadly generated by outer hair cells but their contributions to otoacoustic emissions are spatially restricted
title_sort	intracochlear distortion products are broadly generated by outer hair cells but their contributions to otoacoustic emissions are spatially restricted
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eaae1e4c92884ec380ca5fb8a74988f5
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Intracochlear distortion products are broadly generated by outer hair cells but their contributions to otoacoustic emissions are spatially restricted

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