The role of the P2X₇ receptor in infectious diseases.

ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X₇ receptor, the expression of which is upregulated by pro-inflammatory cytokines. Activation of the P2X₇ receptor opens a cation-specific channel that alters the ionic environme...

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Autores principales:	Catherine M Miller, Nicola R Boulter, Stephen J Fuller, Alana M Zakrzewski, Michael P Lees, Bernadette M Saunders, James S Wiley, Nicholas C Smith
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/eaae2f5f8dfd4171bed244a273cb96bf
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spelling	oai:doaj.org-article:eaae2f5f8dfd4171bed244a273cb96bf2021-11-18T06:05:09ZThe role of the P2X₇ receptor in infectious diseases.1553-73661553-737410.1371/journal.ppat.1002212https://doaj.org/article/eaae2f5f8dfd4171bed244a273cb96bf2011-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22102807/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X₇ receptor, the expression of which is upregulated by pro-inflammatory cytokines. Activation of the P2X₇ receptor opens a cation-specific channel that alters the ionic environment of the cell, activating several pathways, including (i) the inflammasome, leading to production of IL-1β and IL-18; (ii) the stress-activated protein kinase pathway, resulting in apoptosis; (iii) the mitogen-activated protein kinase pathway, leading to generation of reactive oxygen and nitrogen intermediates; and (iv) phospholipase D, stimulating phagosome-lysosome fusion. The P2X₇ receptor can initiate host mechanisms to remove pathogens, most particularly those that parasitise macrophages. At the same time, the P2X₇ receptor may be subverted by pathogens to modulate host responses. Moreover, recent genetic studies have demonstrated significant associations between susceptibility or resistance to parasites and bacteria, and loss-of-function or gain-of-function polymorphisms in the P2X₇ receptor, underscoring its importance in infectious disease.Catherine M MillerNicola R BoulterStephen J FullerAlana M ZakrzewskiMichael P LeesBernadette M SaundersJames S WileyNicholas C SmithPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 7, Iss 11, p e1002212 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Catherine M Miller Nicola R Boulter Stephen J Fuller Alana M Zakrzewski Michael P Lees Bernadette M Saunders James S Wiley Nicholas C Smith The role of the P2X₇ receptor in infectious diseases.
description	ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X₇ receptor, the expression of which is upregulated by pro-inflammatory cytokines. Activation of the P2X₇ receptor opens a cation-specific channel that alters the ionic environment of the cell, activating several pathways, including (i) the inflammasome, leading to production of IL-1β and IL-18; (ii) the stress-activated protein kinase pathway, resulting in apoptosis; (iii) the mitogen-activated protein kinase pathway, leading to generation of reactive oxygen and nitrogen intermediates; and (iv) phospholipase D, stimulating phagosome-lysosome fusion. The P2X₇ receptor can initiate host mechanisms to remove pathogens, most particularly those that parasitise macrophages. At the same time, the P2X₇ receptor may be subverted by pathogens to modulate host responses. Moreover, recent genetic studies have demonstrated significant associations between susceptibility or resistance to parasites and bacteria, and loss-of-function or gain-of-function polymorphisms in the P2X₇ receptor, underscoring its importance in infectious disease.
format	article
author	Catherine M Miller Nicola R Boulter Stephen J Fuller Alana M Zakrzewski Michael P Lees Bernadette M Saunders James S Wiley Nicholas C Smith
author_facet	Catherine M Miller Nicola R Boulter Stephen J Fuller Alana M Zakrzewski Michael P Lees Bernadette M Saunders James S Wiley Nicholas C Smith
author_sort	Catherine M Miller
title	The role of the P2X₇ receptor in infectious diseases.
title_short	The role of the P2X₇ receptor in infectious diseases.
title_full	The role of the P2X₇ receptor in infectious diseases.
title_fullStr	The role of the P2X₇ receptor in infectious diseases.
title_full_unstemmed	The role of the P2X₇ receptor in infectious diseases.
title_sort	role of the p2x₇ receptor in infectious diseases.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/eaae2f5f8dfd4171bed244a273cb96bf
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The role of the P2X₇ receptor in infectious diseases.

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