Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications

We report on the synthesis and characterization of folic acid-conjugated silica-modified TbPO4·H2O nanorods for biomedical applications. The uniform shape TbPO4·H2O nanorods with a hexagonal phase were successfully synthesized by wet chemical methods. A novel TbPO4·H2O@silica-NH2 nanocomplex was the...

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Autores principales:	Le Thi Vinh, Tran Thu Huong, Ha Thi Phuong, Hoang Thi Khuyen, Nguyen Manh Hung, Do Thi Thao, Le Quoc Minh
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Technology (General) T1-995
Acceso en línea:	https://doaj.org/article/eaaea029e39e4afe90a5833c1d497e60
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spelling	oai:doaj.org-article:eaaea029e39e4afe90a5833c1d497e602021-11-08T02:36:52ZFolic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications1687-412910.1155/2021/9888856https://doaj.org/article/eaaea029e39e4afe90a5833c1d497e602021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9888856https://doaj.org/toc/1687-4129We report on the synthesis and characterization of folic acid-conjugated silica-modified TbPO4·H2O nanorods for biomedical applications. The uniform shape TbPO4·H2O nanorods with a hexagonal phase were successfully synthesized by wet chemical methods. A novel TbPO4·H2O@silica-NH2 nanocomplex was then formed by functionalizing these nanorods with silica and conjugating with biological agents. The field emission scanning electron microscopy, energy-dispersive X-ray, and X-ray diffraction reveal the morphology and structure of the nanorods, with their controllable sizes (500-800 nm in length and 50-80 nm in diameter). The Fourier transform infrared spectroscopy was employed to identify chemical substances or functional groups of the TbPO4·H2O@silica-NH2 nanocomplex. The photoluminescence spectra show the four emission lines of TbPO4·H2O@silica-NH2 in folic acid at 488, 540, 585, and 621 nm under 355 nm laser excitation, which could be attributed to the 5D4-7Fj (J=6,5,4,3) transitions of Tb3+. The TbPO4·H2O@silica-NH2 nanorods were conjugated with folic acid for the detection of MCF7 breast cancer cells. The obtained results show a promising possibility for the recognition of living cells that is of crucial importance in biolabeling.Le Thi VinhTran Thu HuongHa Thi PhuongHoang Thi KhuyenNguyen Manh HungDo Thi ThaoLe Quoc MinhHindawi LimitedarticleTechnology (General)T1-995ENJournal of Nanomaterials, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Technology (General) T1-995
spellingShingle	Technology (General) T1-995 Le Thi Vinh Tran Thu Huong Ha Thi Phuong Hoang Thi Khuyen Nguyen Manh Hung Do Thi Thao Le Quoc Minh Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications
description	We report on the synthesis and characterization of folic acid-conjugated silica-modified TbPO4·H2O nanorods for biomedical applications. The uniform shape TbPO4·H2O nanorods with a hexagonal phase were successfully synthesized by wet chemical methods. A novel TbPO4·H2O@silica-NH2 nanocomplex was then formed by functionalizing these nanorods with silica and conjugating with biological agents. The field emission scanning electron microscopy, energy-dispersive X-ray, and X-ray diffraction reveal the morphology and structure of the nanorods, with their controllable sizes (500-800 nm in length and 50-80 nm in diameter). The Fourier transform infrared spectroscopy was employed to identify chemical substances or functional groups of the TbPO4·H2O@silica-NH2 nanocomplex. The photoluminescence spectra show the four emission lines of TbPO4·H2O@silica-NH2 in folic acid at 488, 540, 585, and 621 nm under 355 nm laser excitation, which could be attributed to the 5D4-7Fj (J=6,5,4,3) transitions of Tb3+. The TbPO4·H2O@silica-NH2 nanorods were conjugated with folic acid for the detection of MCF7 breast cancer cells. The obtained results show a promising possibility for the recognition of living cells that is of crucial importance in biolabeling.
format	article
author	Le Thi Vinh Tran Thu Huong Ha Thi Phuong Hoang Thi Khuyen Nguyen Manh Hung Do Thi Thao Le Quoc Minh
author_facet	Le Thi Vinh Tran Thu Huong Ha Thi Phuong Hoang Thi Khuyen Nguyen Manh Hung Do Thi Thao Le Quoc Minh
author_sort	Le Thi Vinh
title	Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications
title_short	Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications
title_full	Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications
title_fullStr	Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications
title_full_unstemmed	Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications
title_sort	folic acid-conjugated silica-modified tbpo4·h2o nanorods for biomedical applications
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/eaaea029e39e4afe90a5833c1d497e60
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Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications

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