INHIBITORY ACTIVITY OF <I>Murraya paniculata</I> AGAINST MYOTOXIC PHOSPHOLIPASES A<SUB>2</SUB>

Envenomation by snakes of the genus Bothrops are a health problem in some tropical countries, not only because of the mortality but given the high percentage of physical disabilities it causes. Phospholipases A2 (PLA2) are abundant constituents in bothropic and crotalic venoms, characterized by indu...

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Autores principales:	Tatiana LOBO E., Jaime A. PEREAÑEZ, Karol Zapata A., Pablo A. GUTIÉRREZ, Mónica LONDOÑO, Vitelbina NÚÑEZ, Benjamín A. ROJANO
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2010
Materias:	phospholipase A<sub>2</sub> <I>Murraya paniculata</I> <I>Bothrops</I> molecular docking. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/eab16061d7a04ea783a735ec4c30b271
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spelling	oai:doaj.org-article:eab16061d7a04ea783a735ec4c30b2712021-11-19T04:14:16ZINHIBITORY ACTIVITY OF <I>Murraya paniculata</I> AGAINST MYOTOXIC PHOSPHOLIPASES A<SUB>2</SUB>0121-40042145-2660https://doaj.org/article/eab16061d7a04ea783a735ec4c30b2712010-11-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/7436https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Envenomation by snakes of the genus Bothrops are a health problem in some tropical countries, not only because of the mortality but given the high percentage of physical disabilities it causes. Phospholipases A2 (PLA2) are abundant constituents in bothropic and crotalic venoms, characterized by inducing irreversible muscle damage. Due to the contribution of plants in the snakebite treatment, we focus on the search of phospholipases inhibitors, either as an alternative treatment or as a therapeutic adjuvant of the current treatments. From a screening of 37 vascular plants and bryophytes in the search for such inhibitors, the species Murraya paniculata was selected due to its promising preliminary activity. Starting from this point further work consisting of bioassay-guided fractionation followed by the evaluation of the inhibitory activity of PLA2, the metabolites responsible for the activity were detected through a tandem of gas chromatography - mass spectrometry in the most active fraction, to propose substrate-enzyme inhibition model. The aims of this project was the search of promising compounds with an inhibitory activity of the PLA2 in vascular plants such as M. paniculata, that could become tools for developing new products to improve the prognosis of the snakebite.Tatiana LOBO E.Jaime A. PEREAÑEZKarol Zapata A.Pablo A. GUTIÉRREZMónica LONDOÑOVitelbina NÚÑEZBenjamín A. ROJANOUniversidad de Antioquiaarticlephospholipase A<sub>2</sub><I>Murraya paniculata</I><I>Bothrops</I>molecular docking.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 17, Iss 3 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	phospholipase A<sub>2</sub> <I>Murraya paniculata</I> <I>Bothrops</I> molecular docking. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	phospholipase A<sub>2</sub> <I>Murraya paniculata</I> <I>Bothrops</I> molecular docking. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Tatiana LOBO E. Jaime A. PEREAÑEZ Karol Zapata A. Pablo A. GUTIÉRREZ Mónica LONDOÑO Vitelbina NÚÑEZ Benjamín A. ROJANO INHIBITORY ACTIVITY OF <I>Murraya paniculata</I> AGAINST MYOTOXIC PHOSPHOLIPASES A<SUB>2</SUB>
description	Envenomation by snakes of the genus Bothrops are a health problem in some tropical countries, not only because of the mortality but given the high percentage of physical disabilities it causes. Phospholipases A2 (PLA2) are abundant constituents in bothropic and crotalic venoms, characterized by inducing irreversible muscle damage. Due to the contribution of plants in the snakebite treatment, we focus on the search of phospholipases inhibitors, either as an alternative treatment or as a therapeutic adjuvant of the current treatments. From a screening of 37 vascular plants and bryophytes in the search for such inhibitors, the species Murraya paniculata was selected due to its promising preliminary activity. Starting from this point further work consisting of bioassay-guided fractionation followed by the evaluation of the inhibitory activity of PLA2, the metabolites responsible for the activity were detected through a tandem of gas chromatography - mass spectrometry in the most active fraction, to propose substrate-enzyme inhibition model. The aims of this project was the search of promising compounds with an inhibitory activity of the PLA2 in vascular plants such as M. paniculata, that could become tools for developing new products to improve the prognosis of the snakebite.
format	article
author	Tatiana LOBO E. Jaime A. PEREAÑEZ Karol Zapata A. Pablo A. GUTIÉRREZ Mónica LONDOÑO Vitelbina NÚÑEZ Benjamín A. ROJANO
author_facet	Tatiana LOBO E. Jaime A. PEREAÑEZ Karol Zapata A. Pablo A. GUTIÉRREZ Mónica LONDOÑO Vitelbina NÚÑEZ Benjamín A. ROJANO
author_sort	Tatiana LOBO E.
title	INHIBITORY ACTIVITY OF <I>Murraya paniculata</I> AGAINST MYOTOXIC PHOSPHOLIPASES A<SUB>2</SUB>
title_short	INHIBITORY ACTIVITY OF <I>Murraya paniculata</I> AGAINST MYOTOXIC PHOSPHOLIPASES A<SUB>2</SUB>
title_full	INHIBITORY ACTIVITY OF <I>Murraya paniculata</I> AGAINST MYOTOXIC PHOSPHOLIPASES A<SUB>2</SUB>
title_fullStr	INHIBITORY ACTIVITY OF <I>Murraya paniculata</I> AGAINST MYOTOXIC PHOSPHOLIPASES A<SUB>2</SUB>
title_full_unstemmed	INHIBITORY ACTIVITY OF <I>Murraya paniculata</I> AGAINST MYOTOXIC PHOSPHOLIPASES A<SUB>2</SUB>
title_sort	inhibitory activity of <i>murraya paniculata</i> against myotoxic phospholipases a<sub>2</sub>
publisher	Universidad de Antioquia
publishDate	2010
url	https://doaj.org/article/eab16061d7a04ea783a735ec4c30b271
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INHIBITORY ACTIVITY OF <I>Murraya paniculata</I> AGAINST MYOTOXIC PHOSPHOLIPASES A<SUB>2</SUB>

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