Level of non-adherence and its associated factors among adults on first-line antiretroviral therapy in Amhara Regional State, Ethiopia.

<h4>Background</h4>In Ethiopia, nearly one-third of people living with human immunodeficiency viruses do not adhere to antiretroviral therapy. Moreover, information regarding non-adherence and its associated factors among adults on first-line antiretroviral therapy in Northeast Ethiopia...

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Autores principales:	Setognal Birara Aychiluhm, Abay Woday Tadesse, Kusse Urmale Mare, Mequannent Sharew Melaku, Ibrahim Mohammed Ibrahim, Osman Ahmed, Oumer Abdulkadir Ebrahim, Mohammed Wagris, Yonatan Menber, Ayesheshim Muluneh Kassa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eab70391950848d79599c00c369d085f
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spelling	oai:doaj.org-article:eab70391950848d79599c00c369d085f2021-12-02T20:18:31ZLevel of non-adherence and its associated factors among adults on first-line antiretroviral therapy in Amhara Regional State, Ethiopia.1932-620310.1371/journal.pone.0255912https://doaj.org/article/eab70391950848d79599c00c369d085f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255912https://doaj.org/toc/1932-6203<h4>Background</h4>In Ethiopia, nearly one-third of people living with human immunodeficiency viruses do not adhere to antiretroviral therapy. Moreover, information regarding non-adherence and its associated factors among adults on first-line antiretroviral therapy in Northeast Ethiopia is limited. Therefore, this study aimed to assess the level of non-adherence and its associated factors among adults on first-line antiretroviral therapy in North Shewa Zone, Amhara Regional State, Ethiopia.<h4>Methods</h4>A facility-based cross-sectional study was conducted on 326 participants selected by systematic random sampling technique from the five randomly selected public health facilities. Data were collected using the questionnaire adapted from the studies conducted previously and the collected data were entered into Epi data version 3.1 and exported to Stata version 14 for further analysis. Multivariable logistic regression analysis was done and an adjusted odds ratio with its corresponding 95% confidence interval was used to declare a statistical significance.<h4>Results</h4>The overall prevalence of non-adherence was 17.4% [95% CI: (12.8%, 21.2%)]. Patients with no formal education [AOR (95% CI) = 5.57 (1.97, 15.88)], those who did not use memory aids to take their medications [AOR (95% CI) = 3.01 (1.27, 7.11)], travel more than 10 kilometers to visit the nearby antiretroviral therapy clinics [AOR (95% CI) = 2.42 (1.22, 25.86)], those who used substance [AOR (95% CI) = 3.57 (1.86, 28.69)], and patients whose medication time interfered with their daily routine activities [AOR (95% CI) = 15.46 (4.41, 54.28) had higher odds of having non-adherence to first-line antiretroviral therapy compared to their counter groups.<h4>Conclusion</h4>The level of non-adherence to first-line antiretroviral therapy was 17.4%, higher compared to WHO's recommendation. Hence, patients counseling focused on avoiding substance use, use memory aids, and adjusting working time with medication schedule are very crucial. Furthermore, the ministry of health and the regional health bureau with other stakeholders should expand antiretroviral therapy service delivery at health facilities that are close to the community to address distance barriers.Setognal Birara AychiluhmAbay Woday TadesseKusse Urmale MareMequannent Sharew MelakuIbrahim Mohammed IbrahimOsman AhmedOumer Abdulkadir EbrahimMohammed WagrisYonatan MenberAyesheshim Muluneh KassaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255912 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Setognal Birara Aychiluhm Abay Woday Tadesse Kusse Urmale Mare Mequannent Sharew Melaku Ibrahim Mohammed Ibrahim Osman Ahmed Oumer Abdulkadir Ebrahim Mohammed Wagris Yonatan Menber Ayesheshim Muluneh Kassa Level of non-adherence and its associated factors among adults on first-line antiretroviral therapy in Amhara Regional State, Ethiopia.
description	<h4>Background</h4>In Ethiopia, nearly one-third of people living with human immunodeficiency viruses do not adhere to antiretroviral therapy. Moreover, information regarding non-adherence and its associated factors among adults on first-line antiretroviral therapy in Northeast Ethiopia is limited. Therefore, this study aimed to assess the level of non-adherence and its associated factors among adults on first-line antiretroviral therapy in North Shewa Zone, Amhara Regional State, Ethiopia.<h4>Methods</h4>A facility-based cross-sectional study was conducted on 326 participants selected by systematic random sampling technique from the five randomly selected public health facilities. Data were collected using the questionnaire adapted from the studies conducted previously and the collected data were entered into Epi data version 3.1 and exported to Stata version 14 for further analysis. Multivariable logistic regression analysis was done and an adjusted odds ratio with its corresponding 95% confidence interval was used to declare a statistical significance.<h4>Results</h4>The overall prevalence of non-adherence was 17.4% [95% CI: (12.8%, 21.2%)]. Patients with no formal education [AOR (95% CI) = 5.57 (1.97, 15.88)], those who did not use memory aids to take their medications [AOR (95% CI) = 3.01 (1.27, 7.11)], travel more than 10 kilometers to visit the nearby antiretroviral therapy clinics [AOR (95% CI) = 2.42 (1.22, 25.86)], those who used substance [AOR (95% CI) = 3.57 (1.86, 28.69)], and patients whose medication time interfered with their daily routine activities [AOR (95% CI) = 15.46 (4.41, 54.28) had higher odds of having non-adherence to first-line antiretroviral therapy compared to their counter groups.<h4>Conclusion</h4>The level of non-adherence to first-line antiretroviral therapy was 17.4%, higher compared to WHO's recommendation. Hence, patients counseling focused on avoiding substance use, use memory aids, and adjusting working time with medication schedule are very crucial. Furthermore, the ministry of health and the regional health bureau with other stakeholders should expand antiretroviral therapy service delivery at health facilities that are close to the community to address distance barriers.
format	article
author	Setognal Birara Aychiluhm Abay Woday Tadesse Kusse Urmale Mare Mequannent Sharew Melaku Ibrahim Mohammed Ibrahim Osman Ahmed Oumer Abdulkadir Ebrahim Mohammed Wagris Yonatan Menber Ayesheshim Muluneh Kassa
author_facet	Setognal Birara Aychiluhm Abay Woday Tadesse Kusse Urmale Mare Mequannent Sharew Melaku Ibrahim Mohammed Ibrahim Osman Ahmed Oumer Abdulkadir Ebrahim Mohammed Wagris Yonatan Menber Ayesheshim Muluneh Kassa
author_sort	Setognal Birara Aychiluhm
title	Level of non-adherence and its associated factors among adults on first-line antiretroviral therapy in Amhara Regional State, Ethiopia.
title_short	Level of non-adherence and its associated factors among adults on first-line antiretroviral therapy in Amhara Regional State, Ethiopia.
title_full	Level of non-adherence and its associated factors among adults on first-line antiretroviral therapy in Amhara Regional State, Ethiopia.
title_fullStr	Level of non-adherence and its associated factors among adults on first-line antiretroviral therapy in Amhara Regional State, Ethiopia.
title_full_unstemmed	Level of non-adherence and its associated factors among adults on first-line antiretroviral therapy in Amhara Regional State, Ethiopia.
title_sort	level of non-adherence and its associated factors among adults on first-line antiretroviral therapy in amhara regional state, ethiopia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/eab70391950848d79599c00c369d085f
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Level of non-adherence and its associated factors among adults on first-line antiretroviral therapy in Amhara Regional State, Ethiopia.

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