Fungal cell wall components modulate our immune system

Invasive fungal infections remain highly problematic for human health. Collectively, they account for more than 1 million deaths a year in addition to more than 100 million mucosal infections and 1 billion skin infections. To be able to make progress it is important to understand the pathobiology of...

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Autores principales:	Benoit Briard, Thierry Fontaine, Thirumala-Devi Kanneganti, Neil A.R. Gow, Nicolas Papon
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Innate immunity Trained immunity Inflammasome Cell death Pyroptosis PANoptosis Cytology QH573-671
Acceso en línea:	https://doaj.org/article/eab76591e3c9454e886ef2352088a305
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spelling	oai:doaj.org-article:eab76591e3c9454e886ef2352088a3052021-11-12T04:43:47ZFungal cell wall components modulate our immune system2468-233010.1016/j.tcsw.2021.100067https://doaj.org/article/eab76591e3c9454e886ef2352088a3052021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2468233021000207https://doaj.org/toc/2468-2330Invasive fungal infections remain highly problematic for human health. Collectively, they account for more than 1 million deaths a year in addition to more than 100 million mucosal infections and 1 billion skin infections. To be able to make progress it is important to understand the pathobiology of fungal interactions with the immune system. Here, we highlight new advancements pointing out the pivotal role of fungal cell wall components (β-glucan, mannan, galactosaminogalactan and melanin) in modulating host immunity and discuss how these open new opportunities for the development of immunomodulatory strategies to combat deadly fungal infectious diseases.Benoit BriardThierry FontaineThirumala-Devi KannegantiNeil A.R. GowNicolas PaponElsevierarticleInnate immunityTrained immunityInflammasomeCell deathPyroptosisPANoptosisCytologyQH573-671ENThe Cell Surface, Vol 7, Iss , Pp 100067- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Innate immunity Trained immunity Inflammasome Cell death Pyroptosis PANoptosis Cytology QH573-671
spellingShingle	Innate immunity Trained immunity Inflammasome Cell death Pyroptosis PANoptosis Cytology QH573-671 Benoit Briard Thierry Fontaine Thirumala-Devi Kanneganti Neil A.R. Gow Nicolas Papon Fungal cell wall components modulate our immune system
description	Invasive fungal infections remain highly problematic for human health. Collectively, they account for more than 1 million deaths a year in addition to more than 100 million mucosal infections and 1 billion skin infections. To be able to make progress it is important to understand the pathobiology of fungal interactions with the immune system. Here, we highlight new advancements pointing out the pivotal role of fungal cell wall components (β-glucan, mannan, galactosaminogalactan and melanin) in modulating host immunity and discuss how these open new opportunities for the development of immunomodulatory strategies to combat deadly fungal infectious diseases.
format	article
author	Benoit Briard Thierry Fontaine Thirumala-Devi Kanneganti Neil A.R. Gow Nicolas Papon
author_facet	Benoit Briard Thierry Fontaine Thirumala-Devi Kanneganti Neil A.R. Gow Nicolas Papon
author_sort	Benoit Briard
title	Fungal cell wall components modulate our immune system
title_short	Fungal cell wall components modulate our immune system
title_full	Fungal cell wall components modulate our immune system
title_fullStr	Fungal cell wall components modulate our immune system
title_full_unstemmed	Fungal cell wall components modulate our immune system
title_sort	fungal cell wall components modulate our immune system
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/eab76591e3c9454e886ef2352088a305
work_keys_str_mv	AT benoitbriard fungalcellwallcomponentsmodulateourimmunesystem AT thierryfontaine fungalcellwallcomponentsmodulateourimmunesystem AT thirumaladevikanneganti fungalcellwallcomponentsmodulateourimmunesystem AT neilargow fungalcellwallcomponentsmodulateourimmunesystem AT nicolaspapon fungalcellwallcomponentsmodulateourimmunesystem
_version_	1718431263022383104

Fungal cell wall components modulate our immune system

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