Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
Stromal cells play various roles in tumor establishment and metastasis. Here the authors, using an ex-vivo model, show that cancer-associated fibroblasts facilitate colon cancer cells invasion in a matrix metalloproteinase-independent manner, likely by pulling and stretching the basement membrane to...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/eabac0b9dbc84f519ed0cf211931944c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:eabac0b9dbc84f519ed0cf211931944c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:eabac0b9dbc84f519ed0cf211931944c2021-12-02T17:06:09ZCancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane10.1038/s41467-017-00985-82041-1723https://doaj.org/article/eabac0b9dbc84f519ed0cf211931944c2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00985-8https://doaj.org/toc/2041-1723Stromal cells play various roles in tumor establishment and metastasis. Here the authors, using an ex-vivo model, show that cancer-associated fibroblasts facilitate colon cancer cells invasion in a matrix metalloproteinase-independent manner, likely by pulling and stretching the basement membrane to form gaps.Alexandros GlentisPhilipp OertlePascale MarianiAleksandra ChikinaFatima El MarjouYoumna AttiehFrancois ZaccariniMarick LaeDamarys LoewFlorent DingliPhilemon SirvenMarie SchoumacherBasile G. GurchenkovMarija PlodinecDanijela Matic VignjevicNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Alexandros Glentis Philipp Oertle Pascale Mariani Aleksandra Chikina Fatima El Marjou Youmna Attieh Francois Zaccarini Marick Lae Damarys Loew Florent Dingli Philemon Sirven Marie Schoumacher Basile G. Gurchenkov Marija Plodinec Danijela Matic Vignjevic Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane |
| description |
Stromal cells play various roles in tumor establishment and metastasis. Here the authors, using an ex-vivo model, show that cancer-associated fibroblasts facilitate colon cancer cells invasion in a matrix metalloproteinase-independent manner, likely by pulling and stretching the basement membrane to form gaps. |
| format |
article |
| author |
Alexandros Glentis Philipp Oertle Pascale Mariani Aleksandra Chikina Fatima El Marjou Youmna Attieh Francois Zaccarini Marick Lae Damarys Loew Florent Dingli Philemon Sirven Marie Schoumacher Basile G. Gurchenkov Marija Plodinec Danijela Matic Vignjevic |
| author_facet |
Alexandros Glentis Philipp Oertle Pascale Mariani Aleksandra Chikina Fatima El Marjou Youmna Attieh Francois Zaccarini Marick Lae Damarys Loew Florent Dingli Philemon Sirven Marie Schoumacher Basile G. Gurchenkov Marija Plodinec Danijela Matic Vignjevic |
| author_sort |
Alexandros Glentis |
| title |
Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane |
| title_short |
Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane |
| title_full |
Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane |
| title_fullStr |
Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane |
| title_full_unstemmed |
Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane |
| title_sort |
cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/eabac0b9dbc84f519ed0cf211931944c |
| work_keys_str_mv |
AT alexandrosglentis cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT philippoertle cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT pascalemariani cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT aleksandrachikina cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT fatimaelmarjou cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT youmnaattieh cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT francoiszaccarini cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT maricklae cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT damarysloew cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT florentdingli cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT philemonsirven cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT marieschoumacher cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT basileggurchenkov cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT marijaplodinec cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane AT danijelamaticvignjevic cancerassociatedfibroblastsinducemetalloproteaseindependentcancercellinvasionofthebasementmembrane |
| _version_ |
1718381766030393344 |