Chromatin regulates IL-33 release and extracellular cytokine activity

Interleukin-33 (IL-33) can be released as a cytokine or transported into the nucleus, but the significance of this nuclear shuttling is not fully understood. Here the authors show that chromatin-binding of IL-33 alters, unexpectedly, the activity of IL-33 both in alarmin release kinetics and recepto...

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Autores principales:	Jared Travers, Mark Rochman, Cora E. Miracle, Jeff E. Habel, Michael Brusilovsky, Julie M. Caldwell, Jeffrey K. Rymer, Marc E. Rothenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eabe5c744cb94aef8a004eeb291a50d3
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spelling	oai:doaj.org-article:eabe5c744cb94aef8a004eeb291a50d32021-12-02T13:24:16ZChromatin regulates IL-33 release and extracellular cytokine activity10.1038/s41467-018-05485-x2041-1723https://doaj.org/article/eabe5c744cb94aef8a004eeb291a50d32018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05485-xhttps://doaj.org/toc/2041-1723Interleukin-33 (IL-33) can be released as a cytokine or transported into the nucleus, but the significance of this nuclear shuttling is not fully understood. Here the authors show that chromatin-binding of IL-33 alters, unexpectedly, the activity of IL-33 both in alarmin release kinetics and receptor signaling capacity.Jared TraversMark RochmanCora E. MiracleJeff E. HabelMichael BrusilovskyJulie M. CaldwellJeffrey K. RymerMarc E. RothenbergNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jared Travers Mark Rochman Cora E. Miracle Jeff E. Habel Michael Brusilovsky Julie M. Caldwell Jeffrey K. Rymer Marc E. Rothenberg Chromatin regulates IL-33 release and extracellular cytokine activity
description	Interleukin-33 (IL-33) can be released as a cytokine or transported into the nucleus, but the significance of this nuclear shuttling is not fully understood. Here the authors show that chromatin-binding of IL-33 alters, unexpectedly, the activity of IL-33 both in alarmin release kinetics and receptor signaling capacity.
format	article
author	Jared Travers Mark Rochman Cora E. Miracle Jeff E. Habel Michael Brusilovsky Julie M. Caldwell Jeffrey K. Rymer Marc E. Rothenberg
author_facet	Jared Travers Mark Rochman Cora E. Miracle Jeff E. Habel Michael Brusilovsky Julie M. Caldwell Jeffrey K. Rymer Marc E. Rothenberg
author_sort	Jared Travers
title	Chromatin regulates IL-33 release and extracellular cytokine activity
title_short	Chromatin regulates IL-33 release and extracellular cytokine activity
title_full	Chromatin regulates IL-33 release and extracellular cytokine activity
title_fullStr	Chromatin regulates IL-33 release and extracellular cytokine activity
title_full_unstemmed	Chromatin regulates IL-33 release and extracellular cytokine activity
title_sort	chromatin regulates il-33 release and extracellular cytokine activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/eabe5c744cb94aef8a004eeb291a50d3
work_keys_str_mv	AT jaredtravers chromatinregulatesil33releaseandextracellularcytokineactivity AT markrochman chromatinregulatesil33releaseandextracellularcytokineactivity AT coraemiracle chromatinregulatesil33releaseandextracellularcytokineactivity AT jeffehabel chromatinregulatesil33releaseandextracellularcytokineactivity AT michaelbrusilovsky chromatinregulatesil33releaseandextracellularcytokineactivity AT juliemcaldwell chromatinregulatesil33releaseandextracellularcytokineactivity AT jeffreykrymer chromatinregulatesil33releaseandextracellularcytokineactivity AT marcerothenberg chromatinregulatesil33releaseandextracellularcytokineactivity
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Chromatin regulates IL-33 release and extracellular cytokine activity

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