Constructal law analysis of Cl− transport in eyes aqueous humor

Abstract Progressive loss-of-vision related to any intraocular disorder is known as glaucoma. Secretion of aqueous humor is physiologically important to provide nutrients and oxygen to the avascular anterior segment and ensuring normal visual function, even if, nowadays reducing the secretory rate t...

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Autores principales: Umberto Lucia, Giulia Grisolia, Maria Rosa Astori
Formato: article
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/eac8f6ee7d7043b4a2ae9c27189da7b3
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spelling oai:doaj.org-article:eac8f6ee7d7043b4a2ae9c27189da7b32021-12-02T15:06:10ZConstructal law analysis of Cl− transport in eyes aqueous humor10.1038/s41598-017-07357-82045-2322https://doaj.org/article/eac8f6ee7d7043b4a2ae9c27189da7b32017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07357-8https://doaj.org/toc/2045-2322Abstract Progressive loss-of-vision related to any intraocular disorder is known as glaucoma. Secretion of aqueous humor is physiologically important to provide nutrients and oxygen to the avascular anterior segment and ensuring normal visual function, even if, nowadays reducing the secretory rate to lower intraocular pressure is a major strategy in treating glaucomatous patients. Understanding the mechanisms and regulation of aqueous humor formation is very important to develop possible new approaches to lower intraocular pressure,but today there isn’t any comprehensive model of the regulation of these component in forming aqueous humor. In this paper Construcal law is used to suggest how the Cl− fluxes can determine the water inflow and outflow, and, consequently, how the intraocular pressure is controlled by these fluxes.Umberto LuciaGiulia GrisoliaMaria Rosa AstoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-4 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Umberto Lucia
Giulia Grisolia
Maria Rosa Astori
Constructal law analysis of Cl− transport in eyes aqueous humor
description Abstract Progressive loss-of-vision related to any intraocular disorder is known as glaucoma. Secretion of aqueous humor is physiologically important to provide nutrients and oxygen to the avascular anterior segment and ensuring normal visual function, even if, nowadays reducing the secretory rate to lower intraocular pressure is a major strategy in treating glaucomatous patients. Understanding the mechanisms and regulation of aqueous humor formation is very important to develop possible new approaches to lower intraocular pressure,but today there isn’t any comprehensive model of the regulation of these component in forming aqueous humor. In this paper Construcal law is used to suggest how the Cl− fluxes can determine the water inflow and outflow, and, consequently, how the intraocular pressure is controlled by these fluxes.
format article
author Umberto Lucia
Giulia Grisolia
Maria Rosa Astori
author_facet Umberto Lucia
Giulia Grisolia
Maria Rosa Astori
author_sort Umberto Lucia
title Constructal law analysis of Cl− transport in eyes aqueous humor
title_short Constructal law analysis of Cl− transport in eyes aqueous humor
title_full Constructal law analysis of Cl− transport in eyes aqueous humor
title_fullStr Constructal law analysis of Cl− transport in eyes aqueous humor
title_full_unstemmed Constructal law analysis of Cl− transport in eyes aqueous humor
title_sort constructal law analysis of cl− transport in eyes aqueous humor
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/eac8f6ee7d7043b4a2ae9c27189da7b3
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AT giuliagrisolia constructallawanalysisofcltransportineyesaqueoushumor
AT mariarosaastori constructallawanalysisofcltransportineyesaqueoushumor
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