Constructal law analysis of Cl− transport in eyes aqueous humor
Abstract Progressive loss-of-vision related to any intraocular disorder is known as glaucoma. Secretion of aqueous humor is physiologically important to provide nutrients and oxygen to the avascular anterior segment and ensuring normal visual function, even if, nowadays reducing the secretory rate t...
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Nature Portfolio
2017
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oai:doaj.org-article:eac8f6ee7d7043b4a2ae9c27189da7b32021-12-02T15:06:10ZConstructal law analysis of Cl− transport in eyes aqueous humor10.1038/s41598-017-07357-82045-2322https://doaj.org/article/eac8f6ee7d7043b4a2ae9c27189da7b32017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07357-8https://doaj.org/toc/2045-2322Abstract Progressive loss-of-vision related to any intraocular disorder is known as glaucoma. Secretion of aqueous humor is physiologically important to provide nutrients and oxygen to the avascular anterior segment and ensuring normal visual function, even if, nowadays reducing the secretory rate to lower intraocular pressure is a major strategy in treating glaucomatous patients. Understanding the mechanisms and regulation of aqueous humor formation is very important to develop possible new approaches to lower intraocular pressure,but today there isn’t any comprehensive model of the regulation of these component in forming aqueous humor. In this paper Construcal law is used to suggest how the Cl− fluxes can determine the water inflow and outflow, and, consequently, how the intraocular pressure is controlled by these fluxes.Umberto LuciaGiulia GrisoliaMaria Rosa AstoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-4 (2017) |
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Medicine R Science Q Umberto Lucia Giulia Grisolia Maria Rosa Astori Constructal law analysis of Cl− transport in eyes aqueous humor |
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Abstract Progressive loss-of-vision related to any intraocular disorder is known as glaucoma. Secretion of aqueous humor is physiologically important to provide nutrients and oxygen to the avascular anterior segment and ensuring normal visual function, even if, nowadays reducing the secretory rate to lower intraocular pressure is a major strategy in treating glaucomatous patients. Understanding the mechanisms and regulation of aqueous humor formation is very important to develop possible new approaches to lower intraocular pressure,but today there isn’t any comprehensive model of the regulation of these component in forming aqueous humor. In this paper Construcal law is used to suggest how the Cl− fluxes can determine the water inflow and outflow, and, consequently, how the intraocular pressure is controlled by these fluxes. |
format |
article |
author |
Umberto Lucia Giulia Grisolia Maria Rosa Astori |
author_facet |
Umberto Lucia Giulia Grisolia Maria Rosa Astori |
author_sort |
Umberto Lucia |
title |
Constructal law analysis of Cl− transport in eyes aqueous humor |
title_short |
Constructal law analysis of Cl− transport in eyes aqueous humor |
title_full |
Constructal law analysis of Cl− transport in eyes aqueous humor |
title_fullStr |
Constructal law analysis of Cl− transport in eyes aqueous humor |
title_full_unstemmed |
Constructal law analysis of Cl− transport in eyes aqueous humor |
title_sort |
constructal law analysis of cl− transport in eyes aqueous humor |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/eac8f6ee7d7043b4a2ae9c27189da7b3 |
work_keys_str_mv |
AT umbertolucia constructallawanalysisofcltransportineyesaqueoushumor AT giuliagrisolia constructallawanalysisofcltransportineyesaqueoushumor AT mariarosaastori constructallawanalysisofcltransportineyesaqueoushumor |
_version_ |
1718388616698265600 |