Constructal law analysis of Cl− transport in eyes aqueous humor

Abstract Progressive loss-of-vision related to any intraocular disorder is known as glaucoma. Secretion of aqueous humor is physiologically important to provide nutrients and oxygen to the avascular anterior segment and ensuring normal visual function, even if, nowadays reducing the secretory rate t...

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Main Authors:	Umberto Lucia, Giulia Grisolia, Maria Rosa Astori
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/eac8f6ee7d7043b4a2ae9c27189da7b3
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spelling	oai:doaj.org-article:eac8f6ee7d7043b4a2ae9c27189da7b32021-12-02T15:06:10ZConstructal law analysis of Cl− transport in eyes aqueous humor10.1038/s41598-017-07357-82045-2322https://doaj.org/article/eac8f6ee7d7043b4a2ae9c27189da7b32017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07357-8https://doaj.org/toc/2045-2322Abstract Progressive loss-of-vision related to any intraocular disorder is known as glaucoma. Secretion of aqueous humor is physiologically important to provide nutrients and oxygen to the avascular anterior segment and ensuring normal visual function, even if, nowadays reducing the secretory rate to lower intraocular pressure is a major strategy in treating glaucomatous patients. Understanding the mechanisms and regulation of aqueous humor formation is very important to develop possible new approaches to lower intraocular pressure,but today there isn’t any comprehensive model of the regulation of these component in forming aqueous humor. In this paper Construcal law is used to suggest how the Cl− fluxes can determine the water inflow and outflow, and, consequently, how the intraocular pressure is controlled by these fluxes.Umberto LuciaGiulia GrisoliaMaria Rosa AstoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-4 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Umberto Lucia Giulia Grisolia Maria Rosa Astori Constructal law analysis of Cl− transport in eyes aqueous humor
description	Abstract Progressive loss-of-vision related to any intraocular disorder is known as glaucoma. Secretion of aqueous humor is physiologically important to provide nutrients and oxygen to the avascular anterior segment and ensuring normal visual function, even if, nowadays reducing the secretory rate to lower intraocular pressure is a major strategy in treating glaucomatous patients. Understanding the mechanisms and regulation of aqueous humor formation is very important to develop possible new approaches to lower intraocular pressure,but today there isn’t any comprehensive model of the regulation of these component in forming aqueous humor. In this paper Construcal law is used to suggest how the Cl− fluxes can determine the water inflow and outflow, and, consequently, how the intraocular pressure is controlled by these fluxes.
format	article
author	Umberto Lucia Giulia Grisolia Maria Rosa Astori
author_facet	Umberto Lucia Giulia Grisolia Maria Rosa Astori
author_sort	Umberto Lucia
title	Constructal law analysis of Cl− transport in eyes aqueous humor
title_short	Constructal law analysis of Cl− transport in eyes aqueous humor
title_full	Constructal law analysis of Cl− transport in eyes aqueous humor
title_fullStr	Constructal law analysis of Cl− transport in eyes aqueous humor
title_full_unstemmed	Constructal law analysis of Cl− transport in eyes aqueous humor
title_sort	constructal law analysis of cl− transport in eyes aqueous humor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/eac8f6ee7d7043b4a2ae9c27189da7b3
work_keys_str_mv	AT umbertolucia constructallawanalysisofcltransportineyesaqueoushumor AT giuliagrisolia constructallawanalysisofcltransportineyesaqueoushumor AT mariarosaastori constructallawanalysisofcltransportineyesaqueoushumor
_version_	1718388616698265600

Constructal law analysis of Cl− transport in eyes aqueous humor

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