Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats

Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats

Jeong-Sup Hong,1,2 Myeong-Kyu Park,1 Min-Seok Kim,1 Jeong-Hyeon Lim,1 Gil-Jong Park,1 Eun-Ho Maeng,1 Jae-Ho Shin,3 Yu-Ri Kim,4 Meyoung-Kon Kim,4 Jong-Kwon Lee,5 Jin-A Park,2 Jong-Choon Kim,6 Ho-Chul Shin2 1Health Care Research Laboratory, Korea Testing and Research Institute, Gimpo, 2College of Ve...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Hong J, Park M, Kim M, Lim J, Park G, Meang E, Shin J, Kim Y, Lee J, Park J, Kim J, Shin H
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/eacb408895364614acaa8a63883770d5
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:eacb408895364614acaa8a63883770d5
record_format dspace
spelling oai:doaj.org-article:eacb408895364614acaa8a63883770d52021-12-02T00:30:28ZEffect of zinc oxide nanoparticles on dams and embryo–fetal development in rats1178-2013https://doaj.org/article/eacb408895364614acaa8a63883770d52014-12-01T00:00:00Zhttp://www.dovepress.com/effect-of-zinc-oxide-nanoparticles-on-dams-andnbspembryondashfetal-dev-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Jeong-Sup Hong,1,2 Myeong-Kyu Park,1 Min-Seok Kim,1 Jeong-Hyeon Lim,1 Gil-Jong Park,1 Eun-Ho Maeng,1 Jae-Ho Shin,3 Yu-Ri Kim,4 Meyoung-Kon Kim,4 Jong-Kwon Lee,5 Jin-A Park,2 Jong-Choon Kim,6 Ho-Chul Shin2 1Health Care Research Laboratory, Korea Testing and Research Institute, Gimpo, 2College of Veterinary Medicine, Konkuk University, Seoul, 3Department of Biomedical Laboratory Science, Eulji University, Seongnam-si, 4Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, 5Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, 6College of Veterinary Medicine, Chonnam National University, Gwangju, Korea Abstract: This study investigated the potential adverse effects of zinc oxide nanoparticles (ZnOSM20[-] NPs; negatively charged, 20 nm) on pregnant dams and embryo–fetal development after maternal exposure over the period of gestational days 5–19 with Sprague Dawley rats. ZnOSM20(-) NPs were administered to pregnant rats by gavage at 0 mg/kg/day, 100 mg/kg/day, 200 mg/kg/day, and 400 mg/kg/day. All dams were subjected to caesarean section on gestational day 20, and all the fetuses were examined for external, visceral, and skeletal alterations. Toxicity in the dams manifested as significantly decreased body weight at 400 mg/kg/day and decreased liver weight, and increased adrenal glands weight at 200 mg/kg/day and 400 mg/kg/day. However, no treatment-related difference in the number of corpora lutea, the number of implantation sites, the implantation rate (%), resorption, dead fetuses, litter size, fetal deaths, fetal and placental weights, and sex ratio were observed between the groups. Morphological examinations of the fetuses demonstrated no significant difference in the incidences of abnormalities between the groups. No significant difference was found in the Zn content of fetal tissue between the control and high-dose groups. These results showed that a 15-day repeated oral dose of ZnOSM20(-) was minimally maternotoxic at dose of 200 mg/kg/day and 400 mg/kg/day. Keywords: nanotoxicology, nanoparticles, zinc oxide, maternal toxicity, developmental toxicity, teratogenicityHong JPark MKim MLim JPark GMeang EShin JKim YKim MLee JPark JKim JShin HDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Supplement 2, Pp 145-157 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Hong J
Park M
Kim M
Lim J
Park G
Meang E
Shin J
Kim Y
Kim M
Lee J
Park J
Kim J
Shin H
Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats
description Jeong-Sup Hong,1,2 Myeong-Kyu Park,1 Min-Seok Kim,1 Jeong-Hyeon Lim,1 Gil-Jong Park,1 Eun-Ho Maeng,1 Jae-Ho Shin,3 Yu-Ri Kim,4 Meyoung-Kon Kim,4 Jong-Kwon Lee,5 Jin-A Park,2 Jong-Choon Kim,6 Ho-Chul Shin2 1Health Care Research Laboratory, Korea Testing and Research Institute, Gimpo, 2College of Veterinary Medicine, Konkuk University, Seoul, 3Department of Biomedical Laboratory Science, Eulji University, Seongnam-si, 4Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, 5Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, 6College of Veterinary Medicine, Chonnam National University, Gwangju, Korea Abstract: This study investigated the potential adverse effects of zinc oxide nanoparticles (ZnOSM20[-] NPs; negatively charged, 20 nm) on pregnant dams and embryo–fetal development after maternal exposure over the period of gestational days 5–19 with Sprague Dawley rats. ZnOSM20(-) NPs were administered to pregnant rats by gavage at 0 mg/kg/day, 100 mg/kg/day, 200 mg/kg/day, and 400 mg/kg/day. All dams were subjected to caesarean section on gestational day 20, and all the fetuses were examined for external, visceral, and skeletal alterations. Toxicity in the dams manifested as significantly decreased body weight at 400 mg/kg/day and decreased liver weight, and increased adrenal glands weight at 200 mg/kg/day and 400 mg/kg/day. However, no treatment-related difference in the number of corpora lutea, the number of implantation sites, the implantation rate (%), resorption, dead fetuses, litter size, fetal deaths, fetal and placental weights, and sex ratio were observed between the groups. Morphological examinations of the fetuses demonstrated no significant difference in the incidences of abnormalities between the groups. No significant difference was found in the Zn content of fetal tissue between the control and high-dose groups. These results showed that a 15-day repeated oral dose of ZnOSM20(-) was minimally maternotoxic at dose of 200 mg/kg/day and 400 mg/kg/day. Keywords: nanotoxicology, nanoparticles, zinc oxide, maternal toxicity, developmental toxicity, teratogenicity
format article
author Hong J
Park M
Kim M
Lim J
Park G
Meang E
Shin J
Kim Y
Kim M
Lee J
Park J
Kim J
Shin H
author_facet Hong J
Park M
Kim M
Lim J
Park G
Meang E
Shin J
Kim Y
Kim M
Lee J
Park J
Kim J
Shin H
author_sort Hong J
title Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats
title_short Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats
title_full Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats
title_fullStr Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats
title_full_unstemmed Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats
title_sort effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/eacb408895364614acaa8a63883770d5
work_keys_str_mv AT hongj effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
AT parkm effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
AT kimm effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
AT limj effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
AT parkg effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
AT meange effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
AT shinj effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
AT kimy effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
AT kimm effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
AT leej effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
AT parkj effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
AT kimj effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
AT shinh effectofzincoxidenanoparticlesondamsandnbspembryondashfetaldevelopmentinrats
_version_ 1718403714698444800

Ejemplares similares