Needle-shaped amphoteric calix[4]arene as a magnetic nanocarrier for simultaneous delivery of anticancer drugs to the breast cancer cells

Mahdi Rahimi,1 Ramin Karimian,2 Ehsan Bahojb Noruzi,3 Khudaverdi Ganbarov,4 Mojtaba Zarei,1 Fadhil S Kamounah,5 Bahman Yousefi,1 Milad Bastami,6 Mehdi Yousefi,7 Hossein Samadi Kafil1 1Drug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; 2Chemical I...

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Autores principales:	Rahimi M, Karimian R, Bahojb Noruzi E, Ganbarov K, Zarei M, Kamounah FS, Yousefi B, Bastami M, Yousefi M, Samadi Kafil H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Green synthesis amphoteric calix[4]arene drug delivery breast cancer and MCF7 cells Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eacca445520b4abaa25e1b2e45dd5842
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spelling	oai:doaj.org-article:eacca445520b4abaa25e1b2e45dd58422021-12-02T11:02:29ZNeedle-shaped amphoteric calix[4]arene as a magnetic nanocarrier for simultaneous delivery of anticancer drugs to the breast cancer cells1178-2013https://doaj.org/article/eacca445520b4abaa25e1b2e45dd58422019-04-01T00:00:00Zhttps://www.dovepress.com/needle-shaped-amphoteric-calix4arene-as-a-magnetic-nanocarrier-for-sim-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mahdi Rahimi,1 Ramin Karimian,2 Ehsan Bahojb Noruzi,3 Khudaverdi Ganbarov,4 Mojtaba Zarei,1 Fadhil S Kamounah,5 Bahman Yousefi,1 Milad Bastami,6 Mehdi Yousefi,7 Hossein Samadi Kafil1 1Drug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; 2Chemical Injuries Research Center, Systems biology and poisonings institute, Baqiyatallah University of Medical Sciences, Tehran, Iran; 3Faculty of Chemistry, Department of Inorganic Chemistry, University of Tabriz, Tabriz, Iran; 4Department of Microbiology, Baku State University, Baku, Republic of Azerbaijan; 5Department of Chemistry, University of Copenhagen, Copenhagen. Denmark; 6Biotechnology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; 7Stem Cell Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Background: Chemotherapy as an important tool for cancer treatment faces many obstacles such as multidrug resistance and adverse toxic effects on healthy tissues. Drug delivery systems has opened a new window to overcome these problems. There has been a strong interest development of new platform and system for delivof chemotherapeutic agents. Purpose: In the present study, a green synthesis method was chosen and performed for preparation of a novel amphoteric calix[4]arene (Calix) macrocycle with low toxicity to the human body. Materials and methods: The amphoteric Calix was coated on the surface of Fe3O4 magnetic nanoparticles and used as a magnetic nanocarrier for simultaneous delivery of two anticancer agents, doxorubicin and methotrexate, against MCF7 cancer cells. Several chemical characterizations were done for validation of prepared nanocarrier, and in vitro loading and release studies of drugs were performed with good encapsulation efficiency. Results: In vitro biological studies including hemolysis assay, erythrocytes sedimentation rate, red blood cells aggregation, cyto cellular internalization, and apoptosis evaluations were performed. Based on results, the developed nanocarrier has many advantages and capability for an efficient codelivery of DOX and MTX, which has a highly potent ability to kill cancer cells. Conclusion: All these results persuade us, this nanocarrier could be effectively used for cancer therapy of MCF7 breast cancer cells and is suitable for use in further animal studies in future investigations. Keywords: green synthesis, amphoteric calix[4]arene, drug delivery, combination therapy, MCF7 cellsRahimi MKarimian RBahojb Noruzi EGanbarov KZarei MKamounah FSYousefi BBastami MYousefi MSamadi Kafil HDove Medical PressarticleGreen synthesisamphoteric calix[4]arenedrug deliverybreast cancerand MCF7 cellsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 2619-2636 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Green synthesis amphoteric calix[4]arene drug delivery breast cancer and MCF7 cells Medicine (General) R5-920
spellingShingle	Green synthesis amphoteric calix[4]arene drug delivery breast cancer and MCF7 cells Medicine (General) R5-920 Rahimi M Karimian R Bahojb Noruzi E Ganbarov K Zarei M Kamounah FS Yousefi B Bastami M Yousefi M Samadi Kafil H Needle-shaped amphoteric calix[4]arene as a magnetic nanocarrier for simultaneous delivery of anticancer drugs to the breast cancer cells
description	Mahdi Rahimi,1 Ramin Karimian,2 Ehsan Bahojb Noruzi,3 Khudaverdi Ganbarov,4 Mojtaba Zarei,1 Fadhil S Kamounah,5 Bahman Yousefi,1 Milad Bastami,6 Mehdi Yousefi,7 Hossein Samadi Kafil1 1Drug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; 2Chemical Injuries Research Center, Systems biology and poisonings institute, Baqiyatallah University of Medical Sciences, Tehran, Iran; 3Faculty of Chemistry, Department of Inorganic Chemistry, University of Tabriz, Tabriz, Iran; 4Department of Microbiology, Baku State University, Baku, Republic of Azerbaijan; 5Department of Chemistry, University of Copenhagen, Copenhagen. Denmark; 6Biotechnology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; 7Stem Cell Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Background: Chemotherapy as an important tool for cancer treatment faces many obstacles such as multidrug resistance and adverse toxic effects on healthy tissues. Drug delivery systems has opened a new window to overcome these problems. There has been a strong interest development of new platform and system for delivof chemotherapeutic agents. Purpose: In the present study, a green synthesis method was chosen and performed for preparation of a novel amphoteric calix[4]arene (Calix) macrocycle with low toxicity to the human body. Materials and methods: The amphoteric Calix was coated on the surface of Fe3O4 magnetic nanoparticles and used as a magnetic nanocarrier for simultaneous delivery of two anticancer agents, doxorubicin and methotrexate, against MCF7 cancer cells. Several chemical characterizations were done for validation of prepared nanocarrier, and in vitro loading and release studies of drugs were performed with good encapsulation efficiency. Results: In vitro biological studies including hemolysis assay, erythrocytes sedimentation rate, red blood cells aggregation, cyto cellular internalization, and apoptosis evaluations were performed. Based on results, the developed nanocarrier has many advantages and capability for an efficient codelivery of DOX and MTX, which has a highly potent ability to kill cancer cells. Conclusion: All these results persuade us, this nanocarrier could be effectively used for cancer therapy of MCF7 breast cancer cells and is suitable for use in further animal studies in future investigations. Keywords: green synthesis, amphoteric calix[4]arene, drug delivery, combination therapy, MCF7 cells
format	article
author	Rahimi M Karimian R Bahojb Noruzi E Ganbarov K Zarei M Kamounah FS Yousefi B Bastami M Yousefi M Samadi Kafil H
author_facet	Rahimi M Karimian R Bahojb Noruzi E Ganbarov K Zarei M Kamounah FS Yousefi B Bastami M Yousefi M Samadi Kafil H
author_sort	Rahimi M
title	Needle-shaped amphoteric calix[4]arene as a magnetic nanocarrier for simultaneous delivery of anticancer drugs to the breast cancer cells
title_short	Needle-shaped amphoteric calix[4]arene as a magnetic nanocarrier for simultaneous delivery of anticancer drugs to the breast cancer cells
title_full	Needle-shaped amphoteric calix[4]arene as a magnetic nanocarrier for simultaneous delivery of anticancer drugs to the breast cancer cells
title_fullStr	Needle-shaped amphoteric calix[4]arene as a magnetic nanocarrier for simultaneous delivery of anticancer drugs to the breast cancer cells
title_full_unstemmed	Needle-shaped amphoteric calix[4]arene as a magnetic nanocarrier for simultaneous delivery of anticancer drugs to the breast cancer cells
title_sort	needle-shaped amphoteric calix[4]arene as a magnetic nanocarrier for simultaneous delivery of anticancer drugs to the breast cancer cells
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/eacca445520b4abaa25e1b2e45dd5842
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Needle-shaped amphoteric calix[4]arene as a magnetic nanocarrier for simultaneous delivery of anticancer drugs to the breast cancer cells

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