A new side-effect of sufentanil: increased monocyte-endothelial adhesion

Abstract Background Opioids have been identified by the World Health Organization to be ‘indispensable for the relief of pain and suffering’. Side-effects, such as nausea, vomiting, postoperative delirium, and effects on breathing, of opioids have been well investigated; however, the influence of op...

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Autores principales:	Dongdong Yuan, Zhaowei Zou, Xianlong Li, Nan Cheng, Na Guo, Guoliang Sun, Dezhao Liu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Monocyte-endothelial adherence Opioids Side-effect Anesthesiology RD78.3-87.3
Acceso en línea:	https://doaj.org/article/eacd817532d34f5c8923de92742a26b2
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spelling	oai:doaj.org-article:eacd817532d34f5c8923de92742a26b22021-11-07T12:18:33ZA new side-effect of sufentanil: increased monocyte-endothelial adhesion10.1186/s12871-021-01487-31471-2253https://doaj.org/article/eacd817532d34f5c8923de92742a26b22021-11-01T00:00:00Zhttps://doi.org/10.1186/s12871-021-01487-3https://doaj.org/toc/1471-2253Abstract Background Opioids have been identified by the World Health Organization to be ‘indispensable for the relief of pain and suffering’. Side-effects, such as nausea, vomiting, postoperative delirium, and effects on breathing, of opioids have been well investigated; however, the influence of opioids on monocyte-endothelial adherence has never been reported. Therefore, we explored the effects of representative opioids, fentanyl, sufentanil, and remifentanil, on monocyte-endothelial adherence and the underlying mechanisms. Methods We built a cell adhesion model with U937 monocytes and human umbilical vein endothelial cells (HUVECs). Two kinds of connexin43 (Cx43) channel inhibitors, 18-α-GA and Gap 27, were used to alter Cx43 channel function in U937 monocytes and HUVECs, respectively, to determine the effects of Cx43 channels on U937-HUVEC adhesion. Subsequently, the effects of fentanyl, sufentanil and remifentanil on Cx43 channel function and U937-HUVEC adhesion were explored. Results When fentanyl, sufentanil and remifentanil acted on monocytes or endothelial cells, their effects on monocyte-endothelial adherence differed. When acting on U937 monocytes, sufentanil significantly increased U937-HUVEC adhesion which was associated with reduced release of ATP from Cx43 channels, while fentanyl and remifentanil did not have these influences. Although sufentanil could also inhibit Cx43 channel function in HUVECs, it had no effect on ATP release from HUVECs or U937-HUVECs adhesion. Conclusions We demonstrated that sufentanil application increases monocyte-endothelial adherence which was associated with reduced release of ATP from Cx43 channels in monocytes. This side-effect of sufentanil should be considered seriously by clinicians.Dongdong YuanZhaowei ZouXianlong LiNan ChengNa GuoGuoliang SunDezhao LiuBMCarticleMonocyte-endothelial adherenceOpioidsSide-effectAnesthesiologyRD78.3-87.3ENBMC Anesthesiology, Vol 21, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Monocyte-endothelial adherence Opioids Side-effect Anesthesiology RD78.3-87.3
spellingShingle	Monocyte-endothelial adherence Opioids Side-effect Anesthesiology RD78.3-87.3 Dongdong Yuan Zhaowei Zou Xianlong Li Nan Cheng Na Guo Guoliang Sun Dezhao Liu A new side-effect of sufentanil: increased monocyte-endothelial adhesion
description	Abstract Background Opioids have been identified by the World Health Organization to be ‘indispensable for the relief of pain and suffering’. Side-effects, such as nausea, vomiting, postoperative delirium, and effects on breathing, of opioids have been well investigated; however, the influence of opioids on monocyte-endothelial adherence has never been reported. Therefore, we explored the effects of representative opioids, fentanyl, sufentanil, and remifentanil, on monocyte-endothelial adherence and the underlying mechanisms. Methods We built a cell adhesion model with U937 monocytes and human umbilical vein endothelial cells (HUVECs). Two kinds of connexin43 (Cx43) channel inhibitors, 18-α-GA and Gap 27, were used to alter Cx43 channel function in U937 monocytes and HUVECs, respectively, to determine the effects of Cx43 channels on U937-HUVEC adhesion. Subsequently, the effects of fentanyl, sufentanil and remifentanil on Cx43 channel function and U937-HUVEC adhesion were explored. Results When fentanyl, sufentanil and remifentanil acted on monocytes or endothelial cells, their effects on monocyte-endothelial adherence differed. When acting on U937 monocytes, sufentanil significantly increased U937-HUVEC adhesion which was associated with reduced release of ATP from Cx43 channels, while fentanyl and remifentanil did not have these influences. Although sufentanil could also inhibit Cx43 channel function in HUVECs, it had no effect on ATP release from HUVECs or U937-HUVECs adhesion. Conclusions We demonstrated that sufentanil application increases monocyte-endothelial adherence which was associated with reduced release of ATP from Cx43 channels in monocytes. This side-effect of sufentanil should be considered seriously by clinicians.
format	article
author	Dongdong Yuan Zhaowei Zou Xianlong Li Nan Cheng Na Guo Guoliang Sun Dezhao Liu
author_facet	Dongdong Yuan Zhaowei Zou Xianlong Li Nan Cheng Na Guo Guoliang Sun Dezhao Liu
author_sort	Dongdong Yuan
title	A new side-effect of sufentanil: increased monocyte-endothelial adhesion
title_short	A new side-effect of sufentanil: increased monocyte-endothelial adhesion
title_full	A new side-effect of sufentanil: increased monocyte-endothelial adhesion
title_fullStr	A new side-effect of sufentanil: increased monocyte-endothelial adhesion
title_full_unstemmed	A new side-effect of sufentanil: increased monocyte-endothelial adhesion
title_sort	new side-effect of sufentanil: increased monocyte-endothelial adhesion
publisher	BMC
publishDate	2021
url	https://doaj.org/article/eacd817532d34f5c8923de92742a26b2
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A new side-effect of sufentanil: increased monocyte-endothelial adhesion

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